Advanced

Quinoline-3-carboxamides modulate primary T cell-dependent B cell responses but do not inhibit functional immunity.

Källberg, Eva LU ; Ivars, Fredrik LU and Leanderson, Tomas LU (2014) In Scandinavian Journal of Immunology 79(4). p.237-243
Abstract
The effect of a quinoline-3-carboxamide on the T-cell-dependent B-cell response was investigated in C57BL/6 mice after NP-CGG immunization. The primary serum response to the hapten was slightly inhibited by treatment with a quinoline-3-carboxamide. This inhibition was paralleled by reduced numbers of germinal center B cells and follicular T cells in the spleen up to 21 days after immunization. Also, both the number of germinal centers formed and their size was reduced by quinoline-3-carboxamide treatment. In contrast to the observation in the primary immune response there was no inhibitory effect on the secondary immune response. These data could help to explain how quinoline-3-carboxamides can modulate immune function in autoimmune... (More)
The effect of a quinoline-3-carboxamide on the T-cell-dependent B-cell response was investigated in C57BL/6 mice after NP-CGG immunization. The primary serum response to the hapten was slightly inhibited by treatment with a quinoline-3-carboxamide. This inhibition was paralleled by reduced numbers of germinal center B cells and follicular T cells in the spleen up to 21 days after immunization. Also, both the number of germinal centers formed and their size was reduced by quinoline-3-carboxamide treatment. In contrast to the observation in the primary immune response there was no inhibitory effect on the secondary immune response. These data could help to explain how quinoline-3-carboxamides can modulate immune function in autoimmune diseases without being immunosuppressive. This article is protected by copyright. All rights reserved. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scandinavian Journal of Immunology
volume
79
issue
4
pages
237 - 243
publisher
Wiley-Blackwell
external identifiers
  • pmid:24383944
  • wos:000333237000002
  • scopus:84897833283
ISSN
1365-3083
DOI
10.1111/sji.12152
language
English
LU publication?
yes
id
60b449e3-47a5-45ed-9383-466d2ef12b16 (old id 4292215)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24383944?dopt=Abstract
date added to LUP
2014-02-06 20:54:28
date last changed
2017-01-01 03:01:43
@article{60b449e3-47a5-45ed-9383-466d2ef12b16,
  abstract     = {The effect of a quinoline-3-carboxamide on the T-cell-dependent B-cell response was investigated in C57BL/6 mice after NP-CGG immunization. The primary serum response to the hapten was slightly inhibited by treatment with a quinoline-3-carboxamide. This inhibition was paralleled by reduced numbers of germinal center B cells and follicular T cells in the spleen up to 21 days after immunization. Also, both the number of germinal centers formed and their size was reduced by quinoline-3-carboxamide treatment. In contrast to the observation in the primary immune response there was no inhibitory effect on the secondary immune response. These data could help to explain how quinoline-3-carboxamides can modulate immune function in autoimmune diseases without being immunosuppressive. This article is protected by copyright. All rights reserved.},
  author       = {Källberg, Eva and Ivars, Fredrik and Leanderson, Tomas},
  issn         = {1365-3083},
  language     = {eng},
  number       = {4},
  pages        = {237--243},
  publisher    = {Wiley-Blackwell},
  series       = {Scandinavian Journal of Immunology},
  title        = {Quinoline-3-carboxamides modulate primary T cell-dependent B cell responses but do not inhibit functional immunity.},
  url          = {http://dx.doi.org/10.1111/sji.12152},
  volume       = {79},
  year         = {2014},
}