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Estrogen receptor content in adenovirus type 9-induced rat mammary tumors

Ankerst, Jaro LU orcid ; Fernö, Mårten LU and Jonsson, Nils LU (1999) In In Vivo 13(2). p.151-153
Abstract

Hormonal factors play an important role in the induction of mammary tumors and tumor-like lesions in adenovirus type 9-inoculated W/Fu rats. Primary Ad 9-induced fibroadenomas contained significantly higher amounts of estrogen receptor (determined by means of enzyme immunoassay) in comparison to normal breast tissue (p = 0.01**) and 'spontaneous' fibroadenomas (p = 0.03*), used as control tissues. The receptor content of serially isografted virus-induced fibroadenomas did not differ significantly from the two types of control tissue. The findings suggest that changes in the estrogen receptor level are of importance in the tumor induction process, but also that additional factors are required for the preservation of tumor characteristics... (More)

Hormonal factors play an important role in the induction of mammary tumors and tumor-like lesions in adenovirus type 9-inoculated W/Fu rats. Primary Ad 9-induced fibroadenomas contained significantly higher amounts of estrogen receptor (determined by means of enzyme immunoassay) in comparison to normal breast tissue (p = 0.01**) and 'spontaneous' fibroadenomas (p = 0.03*), used as control tissues. The receptor content of serially isografted virus-induced fibroadenomas did not differ significantly from the two types of control tissue. The findings suggest that changes in the estrogen receptor level are of importance in the tumor induction process, but also that additional factors are required for the preservation of tumor characteristics as well as for lipoma induction.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adenoviruses, Estrogen, Experimental, Hormone-dependent, Human, Mammary neoplasms, Neoplasms, Oncogenic viruses, Receptors, Steroid
in
In Vivo
volume
13
issue
2
pages
151 - 153
publisher
In vivo
external identifiers
  • pmid:10363172
  • scopus:0032893228
ISSN
0258-851X
language
English
LU publication?
yes
id
42b4c142-1a56-4e78-9ca1-e0719e7bce43
date added to LUP
2020-12-29 16:49:08
date last changed
2024-01-03 02:33:53
@article{42b4c142-1a56-4e78-9ca1-e0719e7bce43,
  abstract     = {{<p>Hormonal factors play an important role in the induction of mammary tumors and tumor-like lesions in adenovirus type 9-inoculated W/Fu rats. Primary Ad 9-induced fibroadenomas contained significantly higher amounts of estrogen receptor (determined by means of enzyme immunoassay) in comparison to normal breast tissue (p = 0.01**) and 'spontaneous' fibroadenomas (p = 0.03*), used as control tissues. The receptor content of serially isografted virus-induced fibroadenomas did not differ significantly from the two types of control tissue. The findings suggest that changes in the estrogen receptor level are of importance in the tumor induction process, but also that additional factors are required for the preservation of tumor characteristics as well as for lipoma induction.</p>}},
  author       = {{Ankerst, Jaro and Fernö, Mårten and Jonsson, Nils}},
  issn         = {{0258-851X}},
  keywords     = {{Adenoviruses; Estrogen; Experimental; Hormone-dependent; Human; Mammary neoplasms; Neoplasms; Oncogenic viruses; Receptors; Steroid}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{151--153}},
  publisher    = {{In vivo}},
  series       = {{In Vivo}},
  title        = {{Estrogen receptor content in adenovirus type 9-induced rat mammary tumors}},
  volume       = {{13}},
  year         = {{1999}},
}