Ischemic brain injury : The importance of calcium, lipolytic activities, and free fatty acids
(1982) In Pathologie Biologie 30(5). p.269-277- Abstract
Ischemic brain insults are accompanied by several metabolic alterations. In the present review, the adverse reactions, which might be important for the outcome of these insults, are those related to phospholipid and polyunsaturated fatty acid metabolism triggered by the disturbed calcium ion homeostasis in combination with energy depletion following ischemia. These conditions lead to an activation of phospholipases and to a decreased rate of phospholipid resynthesis with a concomitant increase in the concentration of free fatty acids, in particular arachidonic acid. During the recirculation phase, when oxygen supply is reestablished, the polyunsaturated arachidonic acid serves as substrate in the cyclo-oxygenase and lipoxygenase... (More)
Ischemic brain insults are accompanied by several metabolic alterations. In the present review, the adverse reactions, which might be important for the outcome of these insults, are those related to phospholipid and polyunsaturated fatty acid metabolism triggered by the disturbed calcium ion homeostasis in combination with energy depletion following ischemia. These conditions lead to an activation of phospholipases and to a decreased rate of phospholipid resynthesis with a concomitant increase in the concentration of free fatty acids, in particular arachidonic acid. During the recirculation phase, when oxygen supply is reestablished, the polyunsaturated arachidonic acid serves as substrate in the cyclo-oxygenase and lipoxygenase pathways leading to the formation of hydroxy- and hydroperoxy fatty acids, prostaglandins and possibly also leuketrienes. These substances have adverse effects on the integrity of cell membranes, irreversibly altering the functional properties of the cells, and also vasomodulator properties influencing the effectiveness of the reperfusion of the brain.
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- author
- Wieloch, T. LU and Siesjo, B. K.
- publishing date
- 1982-01-01
- type
- Contribution to journal
- publication status
- published
- in
- Pathologie Biologie
- volume
- 30
- issue
- 5
- pages
- 9 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:7048218
- scopus:0020082995
- ISSN
- 0369-8114
- language
- English
- LU publication?
- no
- id
- 42c893b1-942a-49e2-a3de-792563036e07
- date added to LUP
- 2019-06-13 17:08:01
- date last changed
- 2024-01-01 10:27:00
@article{42c893b1-942a-49e2-a3de-792563036e07,
abstract = {{<p>Ischemic brain insults are accompanied by several metabolic alterations. In the present review, the adverse reactions, which might be important for the outcome of these insults, are those related to phospholipid and polyunsaturated fatty acid metabolism triggered by the disturbed calcium ion homeostasis in combination with energy depletion following ischemia. These conditions lead to an activation of phospholipases and to a decreased rate of phospholipid resynthesis with a concomitant increase in the concentration of free fatty acids, in particular arachidonic acid. During the recirculation phase, when oxygen supply is reestablished, the polyunsaturated arachidonic acid serves as substrate in the cyclo-oxygenase and lipoxygenase pathways leading to the formation of hydroxy- and hydroperoxy fatty acids, prostaglandins and possibly also leuketrienes. These substances have adverse effects on the integrity of cell membranes, irreversibly altering the functional properties of the cells, and also vasomodulator properties influencing the effectiveness of the reperfusion of the brain.</p>}},
author = {{Wieloch, T. and Siesjo, B. K.}},
issn = {{0369-8114}},
language = {{eng}},
month = {{01}},
number = {{5}},
pages = {{269--277}},
publisher = {{Elsevier}},
series = {{Pathologie Biologie}},
title = {{Ischemic brain injury : The importance of calcium, lipolytic activities, and free fatty acids}},
volume = {{30}},
year = {{1982}},
}