Laser tumor thermotherapy: Is there a clinically relevant effect on the immune system
(2006) Biophotonics and Immune Responses 6087. p.870-870- Abstract
- Laser thermotherapy is interesting from an immunological point of view since it can reduce tumor volume without causing immunosuppression at the same time as it may induce and/or enhance tumor immunity. In a rat liver tumor model, we have demonstrated that laser thermotherapy 1) is superior to surgical resection, 2) gives a strong rejection immunity associated with an immune cellular response of tumor-infiltrating macrophages and CD8 lymphocytes, 3) results in pronounced suppression of the growth of a simultaneous untreated tumor (distant bystander effect), 4) produces an increased anti-tumor lymphocyte proliferative response in tumor-draining and systemic lymph nodes and spleen, and 5) results in increased HSP70 immunoreactivity in tumors... (More)
- Laser thermotherapy is interesting from an immunological point of view since it can reduce tumor volume without causing immunosuppression at the same time as it may induce and/or enhance tumor immunity. In a rat liver tumor model, we have demonstrated that laser thermotherapy 1) is superior to surgical resection, 2) gives a strong rejection immunity associated with an immune cellular response of tumor-infiltrating macrophages and CD8 lymphocytes, 3) results in pronounced suppression of the growth of a simultaneous untreated tumor (distant bystander effect), 4) produces an increased anti-tumor lymphocyte proliferative response in tumor-draining and systemic lymph nodes and spleen, and 5) results in increased HSP70 immunoreactivity in tumors and tumor-infiltrating macrophages. Thus, the evidence for a laser-induced immunologic effect in tumor-bearing rats is strong. Some observations suggest that laser thermotherapy may be used for inducing favorable immunologic effects also in patients. Thus, we have shown a laser-induced bystander effect in a patient with malignant melanoma. In patients with breast cancer we have shown that laser thermotherapy induces intratumoral infiltration of immunocompetent cells like CD68 macrophages and CD8 lymphocytes. Laser thermotherapy is likely to be beneficial mainly when tumor burden is small, that is, when treatment is performed with curative intent, either with laser alone or together with surgical resection. For optimal effect, it appears likely that thermotherapy should be combined with other therapies. Most likely, a clinically meaningful effect can only be proven in prospective randomized studies comparing thermotherapy with other methods, particularly surgical resection. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/617263
- author
- Tranberg, Karl-Göran LU
- organization
- publishing date
- 2006
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Interstitial laser thermotherapy, Immunotherapy, Distant bystander effect, Immune response
- host publication
- Proceedings of SPIE - The International Society for Optical Engineering
- volume
- 6087
- pages
- 870 - 870
- publisher
- International Society for Optical Engineering
- conference name
- Biophotonics and Immune Responses
- conference location
- San Jose, CA, United States
- conference dates
- 2006-01-23 - 2006-01-24
- external identifiers
-
- wos:000237105800008
- scopus:33646205895
- ISSN
- 0277-786X
- 1996-756X
- DOI
- 10.1117/12.651606
- language
- English
- LU publication?
- yes
- id
- 42d7bc61-b279-47c4-a31d-61ee814085fd (old id 617263)
- date added to LUP
- 2016-04-01 12:06:14
- date last changed
- 2024-01-08 08:28:58
@inproceedings{42d7bc61-b279-47c4-a31d-61ee814085fd,
abstract = {{Laser thermotherapy is interesting from an immunological point of view since it can reduce tumor volume without causing immunosuppression at the same time as it may induce and/or enhance tumor immunity. In a rat liver tumor model, we have demonstrated that laser thermotherapy 1) is superior to surgical resection, 2) gives a strong rejection immunity associated with an immune cellular response of tumor-infiltrating macrophages and CD8 lymphocytes, 3) results in pronounced suppression of the growth of a simultaneous untreated tumor (distant bystander effect), 4) produces an increased anti-tumor lymphocyte proliferative response in tumor-draining and systemic lymph nodes and spleen, and 5) results in increased HSP70 immunoreactivity in tumors and tumor-infiltrating macrophages. Thus, the evidence for a laser-induced immunologic effect in tumor-bearing rats is strong. Some observations suggest that laser thermotherapy may be used for inducing favorable immunologic effects also in patients. Thus, we have shown a laser-induced bystander effect in a patient with malignant melanoma. In patients with breast cancer we have shown that laser thermotherapy induces intratumoral infiltration of immunocompetent cells like CD68 macrophages and CD8 lymphocytes. Laser thermotherapy is likely to be beneficial mainly when tumor burden is small, that is, when treatment is performed with curative intent, either with laser alone or together with surgical resection. For optimal effect, it appears likely that thermotherapy should be combined with other therapies. Most likely, a clinically meaningful effect can only be proven in prospective randomized studies comparing thermotherapy with other methods, particularly surgical resection.}},
author = {{Tranberg, Karl-Göran}},
booktitle = {{Proceedings of SPIE - The International Society for Optical Engineering}},
issn = {{0277-786X}},
keywords = {{Interstitial laser thermotherapy; Immunotherapy; Distant bystander effect; Immune response}},
language = {{eng}},
pages = {{870--870}},
publisher = {{International Society for Optical Engineering}},
title = {{Laser tumor thermotherapy: Is there a clinically relevant effect on the immune system}},
url = {{http://dx.doi.org/10.1117/12.651606}},
doi = {{10.1117/12.651606}},
volume = {{6087}},
year = {{2006}},
}