Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Gadolinium contrast media are more nephrotoxic than iodine media. The importance of osmolality in direct renal artery injections

Elmståhl, Barbara LU ; Nyman, Ulf ; Leander, Peter LU ; Chai, Chun-Ming LU ; Golman, Klaes LU ; Björk, Jonas LU orcid and Almén, Torsten LU (2006) In European Radiology 16(12). p.2712-2720
Abstract
A study was undertaken of the role of osmotoxicity in gadolinium (Gd) and iodine contrast media (CM) nephrotoxicity in ischemic porcine kidneys. Test solutions: mannitol iso-osmotic to 0.5 M: gadopentetate (1.96 Osm/kg H2O), 0.5 M: gadodiamide (0.78 Osm/kg H2O) and 0.5 M: iohexol (190 mg I/ml, 0.42 Osm/kg H2O). Each solution was injected [3 ml/kg body weight (BW)] into the balloon-occluded (10 min) renal artery of eight left-sided nephrectomized pigs. The plasma half-life of a glomerular filtration rate (GFR) marker was used to compare their effects on GFR 1-3 h post-injection. The median half-lives of the GFR marker after injection of gadopentetate (1,730 min) and mannitol 1.96 Osm/kg H2O (2,782 min) did not differ statistically (P =... (More)
A study was undertaken of the role of osmotoxicity in gadolinium (Gd) and iodine contrast media (CM) nephrotoxicity in ischemic porcine kidneys. Test solutions: mannitol iso-osmotic to 0.5 M: gadopentetate (1.96 Osm/kg H2O), 0.5 M: gadodiamide (0.78 Osm/kg H2O) and 0.5 M: iohexol (190 mg I/ml, 0.42 Osm/kg H2O). Each solution was injected [3 ml/kg body weight (BW)] into the balloon-occluded (10 min) renal artery of eight left-sided nephrectomized pigs. The plasma half-life of a glomerular filtration rate (GFR) marker was used to compare their effects on GFR 1-3 h post-injection. The median half-lives of the GFR marker after injection of gadopentetate (1,730 min) and mannitol 1.96 Osm/kg H2O (2,782 min) did not differ statistically (P = 0.28), but were significantly longer than after all other solutions (P < 0.001). There was no significant difference (P = 0.06) between gadodiamide (218 min) and mannitol 0.82 Osm/kg H2O (169 min), while there was (P = 0.03) between iohexol (181 min) and mannitol 0.43 Osm/kg H2O (148 min). The difference between gadodiamide and iohexol was significant (P = 0.01). Reduction in GFR, as a marker of nephrotoxicity, induced by gadopentetate correlated with its high osmolality, while the effect of gadodiamide and iohexol may include chemotoxicity. Iohexol molecules were less nephrotoxic than the Gd-CM molecules and contain three-times the number of attenuating atoms per molecule. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Radiology
volume
16
issue
12
pages
2712 - 2720
publisher
Springer Science and Business Media B.V.
external identifiers
  • wos:000242324000010
  • scopus:33847730050
  • pmid:16896701
ISSN
0938-7994
DOI
10.1007/s00330-006-0357-4
language
English
LU publication?
yes
id
42daf59e-9d81-41b9-bb67-869749f641f6 (old id 160184)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16896701&dopt=Abstract
date added to LUP
2016-04-01 12:17:31
date last changed
2025-10-14 10:31:12
@article{42daf59e-9d81-41b9-bb67-869749f641f6,
  abstract     = {{A study was undertaken of the role of osmotoxicity in gadolinium (Gd) and iodine contrast media (CM) nephrotoxicity in ischemic porcine kidneys. Test solutions: mannitol iso-osmotic to 0.5 M: gadopentetate (1.96 Osm/kg H2O), 0.5 M: gadodiamide (0.78 Osm/kg H2O) and 0.5 M: iohexol (190 mg I/ml, 0.42 Osm/kg H2O). Each solution was injected [3 ml/kg body weight (BW)] into the balloon-occluded (10 min) renal artery of eight left-sided nephrectomized pigs. The plasma half-life of a glomerular filtration rate (GFR) marker was used to compare their effects on GFR 1-3 h post-injection. The median half-lives of the GFR marker after injection of gadopentetate (1,730 min) and mannitol 1.96 Osm/kg H2O (2,782 min) did not differ statistically (P = 0.28), but were significantly longer than after all other solutions (P &lt; 0.001). There was no significant difference (P = 0.06) between gadodiamide (218 min) and mannitol 0.82 Osm/kg H2O (169 min), while there was (P = 0.03) between iohexol (181 min) and mannitol 0.43 Osm/kg H2O (148 min). The difference between gadodiamide and iohexol was significant (P = 0.01). Reduction in GFR, as a marker of nephrotoxicity, induced by gadopentetate correlated with its high osmolality, while the effect of gadodiamide and iohexol may include chemotoxicity. Iohexol molecules were less nephrotoxic than the Gd-CM molecules and contain three-times the number of attenuating atoms per molecule.}},
  author       = {{Elmståhl, Barbara and Nyman, Ulf and Leander, Peter and Chai, Chun-Ming and Golman, Klaes and Björk, Jonas and Almén, Torsten}},
  issn         = {{0938-7994}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{2712--2720}},
  publisher    = {{Springer Science and Business Media B.V.}},
  series       = {{European Radiology}},
  title        = {{Gadolinium contrast media are more nephrotoxic than iodine media. The importance of osmolality in direct renal artery injections}},
  url          = {{https://lup.lub.lu.se/search/files/2862967/625548.pdf}},
  doi          = {{10.1007/s00330-006-0357-4}},
  volume       = {{16}},
  year         = {{2006}},
}