Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep
(2021) In Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism- Abstract
- Sleep has evolved as a universal core function to allow for restorative biological processes. Detailed knowledge of metabolic changes necessary for the sleep state in the brain is missing. Herein, we have performed an in-depth metabolic analysis of four mouse brain regions and uncovered region-specific circadian variations. Metabolites linked to oxidative stress were altered during sleep including acylcarnitines, hydroxylated fatty acids, phenolic compounds, and thiol-containing metabolites. These findings provide molecular evidence of a significant metabolic shift of the brain energy metabolism. Specific alterations were observed for brain metabolites that have previously not been associated with a circadian function including the... (More)
- Sleep has evolved as a universal core function to allow for restorative biological processes. Detailed knowledge of metabolic changes necessary for the sleep state in the brain is missing. Herein, we have performed an in-depth metabolic analysis of four mouse brain regions and uncovered region-specific circadian variations. Metabolites linked to oxidative stress were altered during sleep including acylcarnitines, hydroxylated fatty acids, phenolic compounds, and thiol-containing metabolites. These findings provide molecular evidence of a significant metabolic shift of the brain energy metabolism. Specific alterations were observed for brain metabolites that have previously not been associated with a circadian function including the microbiome-derived metabolite ergothioneine that suggests a regulatory function. The pseudopeptide β-citryl-glutamate has been linked to brain development and we have now discovered a previously unknown regioisomer. These metabolites altered by the circadian rhythm represent the foundation for hypothesis-driven studies of the underlying metabolic processes and their function. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/42e2c6a9-a785-4c83-b36e-f54e3fbd8757
- author
- Vallianatou, Theodosia ; Lin, Weifeng ; Bechet, Nicholas LU ; Correia, Mario SP ; Shanbhag, Nagesh C LU ; Lundgaard, Iben LU and Globisch, Daniel
- organization
- publishing date
- 2021-07-22
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Brain metabolism, energy metabolism, gut-brain axis, metabolomics, oxidative stress
- in
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:34293940
- scopus:85111123658
- ISSN
- 1559-7016
- DOI
- 10.1177/0271678X211033358
- language
- English
- LU publication?
- yes
- id
- 42e2c6a9-a785-4c83-b36e-f54e3fbd8757
- date added to LUP
- 2021-08-19 16:10:24
- date last changed
- 2022-05-12 21:25:30
@article{42e2c6a9-a785-4c83-b36e-f54e3fbd8757,
abstract = {{Sleep has evolved as a universal core function to allow for restorative biological processes. Detailed knowledge of metabolic changes necessary for the sleep state in the brain is missing. Herein, we have performed an in-depth metabolic analysis of four mouse brain regions and uncovered region-specific circadian variations. Metabolites linked to oxidative stress were altered during sleep including acylcarnitines, hydroxylated fatty acids, phenolic compounds, and thiol-containing metabolites. These findings provide molecular evidence of a significant metabolic shift of the brain energy metabolism. Specific alterations were observed for brain metabolites that have previously not been associated with a circadian function including the microbiome-derived metabolite ergothioneine that suggests a regulatory function. The pseudopeptide β-citryl-glutamate has been linked to brain development and we have now discovered a previously unknown regioisomer. These metabolites altered by the circadian rhythm represent the foundation for hypothesis-driven studies of the underlying metabolic processes and their function.}},
author = {{Vallianatou, Theodosia and Lin, Weifeng and Bechet, Nicholas and Correia, Mario SP and Shanbhag, Nagesh C and Lundgaard, Iben and Globisch, Daniel}},
issn = {{1559-7016}},
keywords = {{Brain metabolism, energy metabolism, gut-brain axis, metabolomics, oxidative stress}},
language = {{eng}},
month = {{07}},
publisher = {{Nature Publishing Group}},
series = {{Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism}},
title = {{Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep}},
url = {{http://dx.doi.org/10.1177/0271678X211033358}},
doi = {{10.1177/0271678X211033358}},
year = {{2021}},
}