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Cross‐reacting tstas in adeno 7 and 12 tumors demonstrated by 51CR‐Cytotoxicity and isograft rejection tests

Ankerst, Jaro LU orcid and Sjögren, Hans O. LU (1969) In International Journal of Cancer 4(3). p.279-287
Abstract

Antisera of mice hyperimmunized against syngeneic X‐irradiated adeno 12 tumor cells were tested for complement‐dependent cytotoxicity against an adeno 7 and an adeno 12 hamster tumor by a 51Cr‐cytotoxic test, developed to work on non‐lymphoid target cells. Significant isotope release above the level of release obtained after exposure to control sera was recorded with both tumors. There was no similar release from BHK‐C13 control hamster cells. The cytotoxic effect on hamster adeno 7 tumor cells was confirmed by the colony inhibition technique. Furthermore, it was demonstrated by transplantation tests in mice that the hamster adeno 7 tumor cells were immunogenic, causing an isograft immunity to adeno 12 tumors similar to that... (More)

Antisera of mice hyperimmunized against syngeneic X‐irradiated adeno 12 tumor cells were tested for complement‐dependent cytotoxicity against an adeno 7 and an adeno 12 hamster tumor by a 51Cr‐cytotoxic test, developed to work on non‐lymphoid target cells. Significant isotope release above the level of release obtained after exposure to control sera was recorded with both tumors. There was no similar release from BHK‐C13 control hamster cells. The cytotoxic effect on hamster adeno 7 tumor cells was confirmed by the colony inhibition technique. Furthermore, it was demonstrated by transplantation tests in mice that the hamster adeno 7 tumor cells were immunogenic, causing an isograft immunity to adeno 12 tumors similar to that induced by adeno 12 hamster and mouse tumor cells.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cancer
volume
4
issue
3
pages
279 - 287
publisher
John Wiley & Sons Inc.
external identifiers
  • pmid:5801415
  • scopus:0014677362
ISSN
0020-7136
DOI
10.1002/ijc.2910040305
language
English
LU publication?
yes
id
42e436ad-644f-42fe-901f-d075466025ae
date added to LUP
2021-02-01 16:39:25
date last changed
2024-01-03 06:02:53
@article{42e436ad-644f-42fe-901f-d075466025ae,
  abstract     = {{<p>Antisera of mice hyperimmunized against syngeneic X‐irradiated adeno 12 tumor cells were tested for complement‐dependent cytotoxicity against an adeno 7 and an adeno 12 hamster tumor by a <sup>51</sup>Cr‐cytotoxic test, developed to work on non‐lymphoid target cells. Significant isotope release above the level of release obtained after exposure to control sera was recorded with both tumors. There was no similar release from BHK‐C13 control hamster cells. The cytotoxic effect on hamster adeno 7 tumor cells was confirmed by the colony inhibition technique. Furthermore, it was demonstrated by transplantation tests in mice that the hamster adeno 7 tumor cells were immunogenic, causing an isograft immunity to adeno 12 tumors similar to that induced by adeno 12 hamster and mouse tumor cells.</p>}},
  author       = {{Ankerst, Jaro and Sjögren, Hans O.}},
  issn         = {{0020-7136}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{279--287}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Cross‐reacting tstas in adeno 7 and 12 tumors demonstrated by <sup>51</sup>CR‐Cytotoxicity and isograft rejection tests}},
  url          = {{http://dx.doi.org/10.1002/ijc.2910040305}},
  doi          = {{10.1002/ijc.2910040305}},
  volume       = {{4}},
  year         = {{1969}},
}