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Safety and Preliminary Efficacy of Ultrasound-guided Percutaneous Irreversible Electroporation for Treatment of Localized Pancreatic Cancer

Mansson, Christopher; Bergenfeldt, Magnus LU ; Brahmstaedt, Richard; Karlson, Britt-Marie; Nygren, Peter and Nilsson, Anders (2014) In Anticancer Research 34(1A). p.289-293
Abstract
Background: Irreversible electroporation (IRE) is a local tumor treatment. Thin needles are placed percutaneously around the tumor under ultrasound guidance. Short pulses of direct current sent through the tissue irreversibly increase cell membrane permeability leading to cell death. We report a phase I study assessing the safety of ultrasound guided percutaneous IRE in patients with localized pancreatic cancer (LPC). Patients and Methods: Five patients (three males) with LPC, judged unsuitable for surgery, chemotherapy, or non-resectable after standard oncological treatment, were treated with IRE. The treatment was given under general anesthesia with muscle relaxation. Results: No serious treatment-related adverse events were observed.... (More)
Background: Irreversible electroporation (IRE) is a local tumor treatment. Thin needles are placed percutaneously around the tumor under ultrasound guidance. Short pulses of direct current sent through the tissue irreversibly increase cell membrane permeability leading to cell death. We report a phase I study assessing the safety of ultrasound guided percutaneous IRE in patients with localized pancreatic cancer (LPC). Patients and Methods: Five patients (three males) with LPC, judged unsuitable for surgery, chemotherapy, or non-resectable after standard oncological treatment, were treated with IRE. The treatment was given under general anesthesia with muscle relaxation. Results: No serious treatment-related adverse events were observed. There was no 30-day mortality. One patient went on to laparotomy and had a R0 pancreaticoduodenectomy with portal vein resection. Six months after the treatment, two patients had no signs of recurrence on computed tomography or contrast-enhanced ultrasound. Conclusion: IRE for LPC can be safely performed percutaneously under ultrasound guidance, with promising initial results regarding efficacy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Pancreatic cancer, tumor ablation, safety, irreversible electroporation, ultrasound guidance
in
Anticancer Research
volume
34
issue
1A
pages
289 - 293
publisher
International Institute of Cancer Research
external identifiers
  • wos:000329765300037
  • scopus:84897021944
ISSN
1791-7530
language
English
LU publication?
yes
id
5ca1a2d0-fc9f-4143-9e8b-677820cd0cea (old id 4319093)
date added to LUP
2014-03-03 07:58:55
date last changed
2017-08-13 03:03:39
@article{5ca1a2d0-fc9f-4143-9e8b-677820cd0cea,
  abstract     = {Background: Irreversible electroporation (IRE) is a local tumor treatment. Thin needles are placed percutaneously around the tumor under ultrasound guidance. Short pulses of direct current sent through the tissue irreversibly increase cell membrane permeability leading to cell death. We report a phase I study assessing the safety of ultrasound guided percutaneous IRE in patients with localized pancreatic cancer (LPC). Patients and Methods: Five patients (three males) with LPC, judged unsuitable for surgery, chemotherapy, or non-resectable after standard oncological treatment, were treated with IRE. The treatment was given under general anesthesia with muscle relaxation. Results: No serious treatment-related adverse events were observed. There was no 30-day mortality. One patient went on to laparotomy and had a R0 pancreaticoduodenectomy with portal vein resection. Six months after the treatment, two patients had no signs of recurrence on computed tomography or contrast-enhanced ultrasound. Conclusion: IRE for LPC can be safely performed percutaneously under ultrasound guidance, with promising initial results regarding efficacy.},
  author       = {Mansson, Christopher and Bergenfeldt, Magnus and Brahmstaedt, Richard and Karlson, Britt-Marie and Nygren, Peter and Nilsson, Anders},
  issn         = {1791-7530},
  keyword      = {Pancreatic cancer,tumor ablation,safety,irreversible electroporation,ultrasound guidance},
  language     = {eng},
  number       = {1A},
  pages        = {289--293},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer Research},
  title        = {Safety and Preliminary Efficacy of Ultrasound-guided Percutaneous Irreversible Electroporation for Treatment of Localized Pancreatic Cancer},
  volume       = {34},
  year         = {2014},
}