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Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa

Komori, Shiori LU ; Ueno, Shinji; Ito, Yasuki; Sayo, Akira; Meinert, Monika LU ; Kominami, Taro; Inooka, Daiki; Kitagawa, Masahiro; Nishida, Kazuki and Takahashi, Kunihiko, et al. (2019) In Investigative Ophthalmology & Visual Science 60(8). p.3135-3141
Abstract

Purpose: A posterior staphyloma has been reported to be present in some eyes with retinitis pigmentosa (RP), and the purpose of this study was to determine the macular curvature of non-highly myopic RP eyes. Methods: This was a retrospective, observational study. The medical charts of the right eyes of 143 patients with RP and 60 controls whose axial length ranged from 21.5 mm to 26.0 mm were reviewed. The mean curvature of Bruch's membrane within 6 mm of the central macula obtained from the horizontal optical coherence tomographic images were evaluated as the mean macular curvature index (MMCI). The relationships between the MMCI and other clinical factors were assessed. Results: The mean MMCI of RP patients (-13.73 ± 9.63 × 10-5 μm-1)... (More)

Purpose: A posterior staphyloma has been reported to be present in some eyes with retinitis pigmentosa (RP), and the purpose of this study was to determine the macular curvature of non-highly myopic RP eyes. Methods: This was a retrospective, observational study. The medical charts of the right eyes of 143 patients with RP and 60 controls whose axial length ranged from 21.5 mm to 26.0 mm were reviewed. The mean curvature of Bruch's membrane within 6 mm of the central macula obtained from the horizontal optical coherence tomographic images were evaluated as the mean macular curvature index (MMCI). The relationships between the MMCI and other clinical factors were assessed. Results: The mean MMCI of RP patients (-13.73 ± 9.63 × 10-5 μm-1) was significantly lower than that of the controls (-6.63 ± 5.63 × 10-5 μm-1). This indicated a deeper concave shape of the macula in RP eyes (P < 0.001). The MMCI was significantly correlated with the age (r = 0.20; P = 0.016) and the axial length (r = -0.24; P = 0.004). Further analysis suggested a nonlinear effect of the ellipsoid zone width on the macular curvature in the RP eyes. Conclusions: There is a high incidence of steeper macular curvatures even in non-highly myopic RP eyes, and the steepness was also affected by the degree of photoreceptor degeneration.

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publication status
published
subject
in
Investigative Ophthalmology & Visual Science
volume
60
issue
8
pages
7 pages
publisher
ASSOC RESEARCH VISION OPHTHALMOLOGY INC
external identifiers
  • scopus:85070449531
ISSN
1552-5783
DOI
10.1167/iovs.19-27334
language
English
LU publication?
yes
id
432b0b7e-c459-4643-9d0b-164cbc0450a4
date added to LUP
2019-08-30 11:16:18
date last changed
2019-09-17 04:59:40
@article{432b0b7e-c459-4643-9d0b-164cbc0450a4,
  abstract     = {<p>Purpose: A posterior staphyloma has been reported to be present in some eyes with retinitis pigmentosa (RP), and the purpose of this study was to determine the macular curvature of non-highly myopic RP eyes. Methods: This was a retrospective, observational study. The medical charts of the right eyes of 143 patients with RP and 60 controls whose axial length ranged from 21.5 mm to 26.0 mm were reviewed. The mean curvature of Bruch's membrane within 6 mm of the central macula obtained from the horizontal optical coherence tomographic images were evaluated as the mean macular curvature index (MMCI). The relationships between the MMCI and other clinical factors were assessed. Results: The mean MMCI of RP patients (-13.73 ± 9.63 × 10-5 μm-1) was significantly lower than that of the controls (-6.63 ± 5.63 × 10-5 μm-1). This indicated a deeper concave shape of the macula in RP eyes (P &lt; 0.001). The MMCI was significantly correlated with the age (r = 0.20; P = 0.016) and the axial length (r = -0.24; P = 0.004). Further analysis suggested a nonlinear effect of the ellipsoid zone width on the macular curvature in the RP eyes. Conclusions: There is a high incidence of steeper macular curvatures even in non-highly myopic RP eyes, and the steepness was also affected by the degree of photoreceptor degeneration.</p>},
  author       = {Komori, Shiori and Ueno, Shinji and Ito, Yasuki and Sayo, Akira and Meinert, Monika and Kominami, Taro and Inooka, Daiki and Kitagawa, Masahiro and Nishida, Kazuki and Takahashi, Kunihiko and Matsui, Shigeyuki and Terasaki, Hiroko},
  issn         = {1552-5783},
  language     = {eng},
  month        = {07},
  number       = {8},
  pages        = {3135--3141},
  publisher    = {ASSOC RESEARCH VISION OPHTHALMOLOGY INC},
  series       = {Investigative Ophthalmology & Visual Science},
  title        = {Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa},
  url          = {http://dx.doi.org/10.1167/iovs.19-27334},
  volume       = {60},
  year         = {2019},
}