The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels.
(2014) In Genes & Nutrition 9(2). p.388-388- Abstract
- The Ile148Met (rs738409, G-allele) in the patatin-like phospholipase domain-containing protein 3 gene (PNPLA3) associates with liver fat content and may lead to loss-of-function (hydrolysis) or gain-of-function (CoA-dependent lysophosphatidic acid acyltransferase) defects. PNPLA3 is up-regulated by dietary carbohydrates, and interactions between rs738409 and carbohydrates, and sugar and ω6:ω3-polyunsaturated fatty acid (PUFA) ratio on hepatic fat accumulation have been reported. We examined interaction between rs738409 and overweight, and between rs738409 and dietary intakes (carbohydrates, sucrose and ω6:ω3-PUFA ratio), on fasting triglyceride levels. From the Malmo Diet and Cancer Study-Cardiovascular Cohort, 4,827 individuals without... (More)
- The Ile148Met (rs738409, G-allele) in the patatin-like phospholipase domain-containing protein 3 gene (PNPLA3) associates with liver fat content and may lead to loss-of-function (hydrolysis) or gain-of-function (CoA-dependent lysophosphatidic acid acyltransferase) defects. PNPLA3 is up-regulated by dietary carbohydrates, and interactions between rs738409 and carbohydrates, and sugar and ω6:ω3-polyunsaturated fatty acid (PUFA) ratio on hepatic fat accumulation have been reported. We examined interaction between rs738409 and overweight, and between rs738409 and dietary intakes (carbohydrates, sucrose and ω6:ω3-PUFA ratio), on fasting triglyceride levels. From the Malmo Diet and Cancer Study-Cardiovascular Cohort, 4,827 individuals without diabetes aged 58 ± 6 years, 2,346 with BMI ≤ 25 kg/m(2) and 2,478 with BMI > 25 kg/m(2), were included in cross-sectional analyses. Dietary data were collected by a modified diet history method. Overweight modified the association between rs738409 and fasting triglyceride levels (P interaction = 0.003). G-allele associated with lower triglycerides only among overweight individuals (P = 0.01). Nominally, significant interaction on triglyceride levels was observed between rs738409 and sucrose among normal-weight individuals (P interaction = 0.03). G-allele associated with lower triglycerides among overweight individuals in the lowest tertiles of carbohydrate and ω6:ω3-PUFA ratio (P = 0.04 and P = 0.001) and with higher triglycerides among normal-weight individuals in the highest tertile of sucrose (P = 0.001). We conclude that overweight and dietary sucrose may modify the association between rs738409 and fasting triglyceride levels. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4334067
- author
- Stojkovic, Ivana LU ; Ericson, Ulrika LU ; Rukh, Gull LU ; Riddestråle, Martin ; Romeo, Stefano and Orho-Melander, Marju LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Genes & Nutrition
- volume
- 9
- issue
- 2
- pages
- 388 - 388
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:24563329
- wos:000333704000008
- scopus:84899490056
- pmid:24563329
- ISSN
- 1555-8932
- DOI
- 10.1007/s12263-014-0388-4
- language
- English
- LU publication?
- yes
- id
- 3d9e81a3-108c-4c85-a71c-d54874318fc4 (old id 4334067)
- date added to LUP
- 2016-04-04 08:54:07
- date last changed
- 2022-03-23 03:09:12
@article{3d9e81a3-108c-4c85-a71c-d54874318fc4,
abstract = {{The Ile148Met (rs738409, G-allele) in the patatin-like phospholipase domain-containing protein 3 gene (PNPLA3) associates with liver fat content and may lead to loss-of-function (hydrolysis) or gain-of-function (CoA-dependent lysophosphatidic acid acyltransferase) defects. PNPLA3 is up-regulated by dietary carbohydrates, and interactions between rs738409 and carbohydrates, and sugar and ω6:ω3-polyunsaturated fatty acid (PUFA) ratio on hepatic fat accumulation have been reported. We examined interaction between rs738409 and overweight, and between rs738409 and dietary intakes (carbohydrates, sucrose and ω6:ω3-PUFA ratio), on fasting triglyceride levels. From the Malmo Diet and Cancer Study-Cardiovascular Cohort, 4,827 individuals without diabetes aged 58 ± 6 years, 2,346 with BMI ≤ 25 kg/m(2) and 2,478 with BMI > 25 kg/m(2), were included in cross-sectional analyses. Dietary data were collected by a modified diet history method. Overweight modified the association between rs738409 and fasting triglyceride levels (P interaction = 0.003). G-allele associated with lower triglycerides only among overweight individuals (P = 0.01). Nominally, significant interaction on triglyceride levels was observed between rs738409 and sucrose among normal-weight individuals (P interaction = 0.03). G-allele associated with lower triglycerides among overweight individuals in the lowest tertiles of carbohydrate and ω6:ω3-PUFA ratio (P = 0.04 and P = 0.001) and with higher triglycerides among normal-weight individuals in the highest tertile of sucrose (P = 0.001). We conclude that overweight and dietary sucrose may modify the association between rs738409 and fasting triglyceride levels.}},
author = {{Stojkovic, Ivana and Ericson, Ulrika and Rukh, Gull and Riddestråle, Martin and Romeo, Stefano and Orho-Melander, Marju}},
issn = {{1555-8932}},
language = {{eng}},
number = {{2}},
pages = {{388--388}},
publisher = {{BioMed Central (BMC)}},
series = {{Genes & Nutrition}},
title = {{The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels.}},
url = {{http://dx.doi.org/10.1007/s12263-014-0388-4}},
doi = {{10.1007/s12263-014-0388-4}},
volume = {{9}},
year = {{2014}},
}