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Toll-Like Receptor 3 Signalling Up-Regulates Expression of the HIV Co-Receptor G-Protein Coupled Receptor 15 on Human CD4(+) T Cells.

Kiene, Miriam ; Rethi, Bence ; Jansson, Marianne LU ; Dillon, Stephanie ; Lee, Eric ; Lantto, Rebecka ; Wilson, Cara ; Pöhlmann, Stefan and Chiodi, Francesca (2014) In PLoS ONE 9(2).
Abstract
Many HIV-2 and SIV isolates, as well as some HIV-1 strains, can use the orphan 7-transmembrane receptor GPR15 as co-receptor for efficient entry into host cells. GPR15 is expressed on central memory and effector memory CD4(+) T cells in healthy individuals and a subset of these cells is susceptible to HIV-1 and SIV infection. However, it has not been determined whether GPR15 expression is altered in the context of HIV-1 infection.
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
9
issue
2
article number
e88195
publisher
Public Library of Science (PLoS)
external identifiers
  • pmid:24558379
  • wos:000331706700025
  • scopus:84895891496
  • pmid:24558379
ISSN
1932-6203
DOI
10.1371/journal.pone.0088195
language
English
LU publication?
yes
id
769984f9-ef12-4b00-a4c3-af787bdefc8d (old id 4334314)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24558379?dopt=Abstract
date added to LUP
2016-04-01 13:52:18
date last changed
2021-09-22 05:09:06
@article{769984f9-ef12-4b00-a4c3-af787bdefc8d,
  abstract     = {Many HIV-2 and SIV isolates, as well as some HIV-1 strains, can use the orphan 7-transmembrane receptor GPR15 as co-receptor for efficient entry into host cells. GPR15 is expressed on central memory and effector memory CD4(+) T cells in healthy individuals and a subset of these cells is susceptible to HIV-1 and SIV infection. However, it has not been determined whether GPR15 expression is altered in the context of HIV-1 infection.},
  author       = {Kiene, Miriam and Rethi, Bence and Jansson, Marianne and Dillon, Stephanie and Lee, Eric and Lantto, Rebecka and Wilson, Cara and Pöhlmann, Stefan and Chiodi, Francesca},
  issn         = {1932-6203},
  language     = {eng},
  number       = {2},
  publisher    = {Public Library of Science (PLoS)},
  series       = {PLoS ONE},
  title        = {Toll-Like Receptor 3 Signalling Up-Regulates Expression of the HIV Co-Receptor G-Protein Coupled Receptor 15 on Human CD4(+) T Cells.},
  url          = {https://lup.lub.lu.se/search/files/3637645/4611029.pdf},
  doi          = {10.1371/journal.pone.0088195},
  volume       = {9},
  year         = {2014},
}