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Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease.

George, Sonia LU ; Rönnbäck, Annica ; Gouras, Gunnar LU orcid ; Petit, Géraldine LU ; Grueninger, Fiona ; Winblad, Bengt ; Graff, Caroline and Brundin, Patrik LU (2014) In Acta Neuropathologica Communications 2(1).
Abstract
The progressive development of Alzheimer's disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the arctic (E693G) mutation, pathology spreads along anatomically connected structures. Amyloid-β (Aβ) pathology first appears in the subiculum and is later detected in interconnected brain regions, including the retrosplenial cortex. We investigated whether the spatiotemporal pattern of Aβ pathology in the Tg APP arctic mice to interconnected brain structures can be interrupted by destroying neurons using a neurotoxin and thereby disconnecting the neural circuitry.
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Neuropathologica Communications
volume
2
issue
1
article number
17
publisher
BioMed Central (BMC)
external identifiers
  • pmid:24517102
  • scopus:84921298275
  • pmid:24517102
  • wos:000422389300017
ISSN
2051-5960
DOI
10.1186/2051-5960-2-17
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Experimental Dementia Research (013210013)
id
5960839c-f801-46e3-be52-d77427233dba (old id 4334865)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24517102?dopt=Abstract
date added to LUP
2016-04-01 14:28:58
date last changed
2021-10-06 02:54:01
@article{5960839c-f801-46e3-be52-d77427233dba,
  abstract     = {The progressive development of Alzheimer's disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the arctic (E693G) mutation, pathology spreads along anatomically connected structures. Amyloid-β (Aβ) pathology first appears in the subiculum and is later detected in interconnected brain regions, including the retrosplenial cortex. We investigated whether the spatiotemporal pattern of Aβ pathology in the Tg APP arctic mice to interconnected brain structures can be interrupted by destroying neurons using a neurotoxin and thereby disconnecting the neural circuitry.},
  author       = {George, Sonia and Rönnbäck, Annica and Gouras, Gunnar and Petit, Géraldine and Grueninger, Fiona and Winblad, Bengt and Graff, Caroline and Brundin, Patrik},
  issn         = {2051-5960},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central (BMC)},
  series       = {Acta Neuropathologica Communications},
  title        = {Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease.},
  url          = {https://lup.lub.lu.se/search/files/3999700/4628817.pdf},
  doi          = {10.1186/2051-5960-2-17},
  volume       = {2},
  year         = {2014},
}