Advanced

Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease.

George, Sonia LU ; Rönnbäck, Annica; Gouras, Gunnar LU ; Petit, Géraldine LU ; Grueninger, Fiona; Winblad, Bengt; Graff, Caroline and Brundin, Patrik LU (2014) In Acta neuropathologica communications 2(1).
Abstract
The progressive development of Alzheimer's disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the arctic (E693G) mutation, pathology spreads along anatomically connected structures. Amyloid-β (Aβ) pathology first appears in the subiculum and is later detected in interconnected brain regions, including the retrosplenial cortex. We investigated whether the spatiotemporal pattern of Aβ pathology in the Tg APP arctic mice to interconnected brain structures can be interrupted by destroying neurons using a neurotoxin and thereby disconnecting the neural circuitry.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta neuropathologica communications
volume
2
issue
1
publisher
BioMed Central
external identifiers
  • pmid:24517102
  • scopus:84921298275
ISSN
2051-5960
DOI
10.1186/2051-5960-2-17
language
English
LU publication?
yes
id
5960839c-f801-46e3-be52-d77427233dba (old id 4334865)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24517102?dopt=Abstract
date added to LUP
2014-03-06 10:54:59
date last changed
2017-11-12 03:45:47
@article{5960839c-f801-46e3-be52-d77427233dba,
  abstract     = {The progressive development of Alzheimer's disease (AD) pathology follows a spatiotemporal pattern in the human brain. In a transgenic (Tg) mouse model of AD expressing amyloid precursor protein (APP) with the arctic (E693G) mutation, pathology spreads along anatomically connected structures. Amyloid-β (Aβ) pathology first appears in the subiculum and is later detected in interconnected brain regions, including the retrosplenial cortex. We investigated whether the spatiotemporal pattern of Aβ pathology in the Tg APP arctic mice to interconnected brain structures can be interrupted by destroying neurons using a neurotoxin and thereby disconnecting the neural circuitry.},
  articleno    = {17},
  author       = {George, Sonia and Rönnbäck, Annica and Gouras, Gunnar and Petit, Géraldine and Grueninger, Fiona and Winblad, Bengt and Graff, Caroline and Brundin, Patrik},
  issn         = {2051-5960},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Acta neuropathologica communications},
  title        = {Lesion of the subiculum reduces the spread of amyloid beta pathology to interconnected brain regions in a mouse model of Alzheimer's disease.},
  url          = {http://dx.doi.org/10.1186/2051-5960-2-17},
  volume       = {2},
  year         = {2014},
}