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Exposure to Polybrominated Diphenyl Ethers and Male Reproductive Function in Greenland, Poland and Ukraine.

Toft, Gunnar; Lenters, Virissa; Vermeulen, Roel; Heederik, Dick; Thomsen, Cathrine; Becher, Georg; Giwercman, Aleksander LU ; Bizzaro, Davide; Manicardi, Gian Carlo and Spanò, Marcello, et al. (2014) In Reproductive Toxicology 43. p.1-7
Abstract
Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not... (More)
Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations. (Less)
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Reproductive Toxicology
volume
43
pages
1 - 7
publisher
Elsevier
external identifiers
  • pmid:24513925
  • wos:000331028900001
  • scopus:84887514890
ISSN
1873-1708
DOI
10.1016/j.reprotox.2013.10.002
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English
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yes
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a15cab9d-4921-4031-8387-5c0600a45771 (old id 4334954)
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http://www.ncbi.nlm.nih.gov/pubmed/24513925?dopt=Abstract
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2014-03-06 11:45:54
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@article{a15cab9d-4921-4031-8387-5c0600a45771,
  abstract     = {Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations.},
  author       = {Toft, Gunnar and Lenters, Virissa and Vermeulen, Roel and Heederik, Dick and Thomsen, Cathrine and Becher, Georg and Giwercman, Aleksander and Bizzaro, Davide and Manicardi, Gian Carlo and Spanò, Marcello and Rylander, Lars and Pedersen, Henning S and Struciński, Paweł and Zviezdai, Valentyna and Bonde, Jens Peter},
  issn         = {1873-1708},
  language     = {eng},
  pages        = {1--7},
  publisher    = {Elsevier},
  series       = {Reproductive Toxicology},
  title        = {Exposure to Polybrominated Diphenyl Ethers and Male Reproductive Function in Greenland, Poland and Ukraine.},
  url          = {http://dx.doi.org/10.1016/j.reprotox.2013.10.002},
  volume       = {43},
  year         = {2014},
}