Family History of Myocardial Infarction Increases Risk of Renal Dysfunction in Middle Age.
Christensson, Anders LU ; Melander, Olle LU
; Fjellstedt, Erik
and Ohlson Andersson, Maria
LU
(2014)
In American Journal of Nephrology
39(2).
p.85-91
- Abstract
- Background/Aims: Chronic kidney disease (CKD) is common in the general population, may lead to end-stage renal disease, and is most frequently found among males. Familial clustering of kidney diseases has been observed. We aimed to study a potential association between the family history of myocardial infarction (MI) and renal dysfunction. Methods: 22,297 males and 10,828 females, aged 33-60 years, from a population-based cohort study were studied. Estimated glomerular filtration rate (eGFR) was assessed by the CKD-EPI creatinine equation. Every participant filled in a self-administered questionnaire including family history. Heredity for MI was defined as mother or father having had MI and/or died from MI, and/or brother or sister having... (More)
- Background/Aims: Chronic kidney disease (CKD) is common in the general population, may lead to end-stage renal disease, and is most frequently found among males. Familial clustering of kidney diseases has been observed. We aimed to study a potential association between the family history of myocardial infarction (MI) and renal dysfunction. Methods: 22,297 males and 10,828 females, aged 33-60 years, from a population-based cohort study were studied. Estimated glomerular filtration rate (eGFR) was assessed by the CKD-EPI creatinine equation. Every participant filled in a self-administered questionnaire including family history. Heredity for MI was defined as mother or father having had MI and/or died from MI, and/or brother or sister having had MI. Binary logistic regression and multiple linear regression were used in the analyses. Results: Multiple linear regression revealed a significantly increased risk of renal dysfunction in those with a positive heredity for MI (the whole cohort p = 0.01, males p = 0.000, females p = 0.169). Binary logistic regression showed that males with heredity for MI with a mean age of 43 years have a 2 times higher risk (p = 0.02) of belonging to the group with GFR <45 ml/min/1.73 m(2) compared to those without heredity. For the whole cohort the increased risk was 1.6 times (p = 0.07). There was no significant association for females (p = 0.88). Conclusion: These findings demonstrate that a familial burden of MI is associated with renal dysfunction, in men, already in middle age. Genetic variants may underlie predisposition to CKD in those with heredity for MI. © 2014 S. Karger AG, Basel. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4336146
- author
- Christensson, Anders
LU
; Melander, Olle
LU
; Fjellstedt, Erik
and Ohlson Andersson, Maria
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- American Journal of Nephrology
- volume
- 39
- issue
- 2
- pages
- 85 - 91
- publisher
- Karger
- external identifiers
-
- pmid:24481112
- wos:000332904300001
- scopus:84893171891
- pmid:24481112
- ISSN
- 1421-9670
- DOI
- 10.1159/000358259
- language
- English
- LU publication?
- yes
- id
- 55666bc2-3b12-489a-8c66-28875a7d30b0 (old id 4336146)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24481112?dopt=Abstract
- date added to LUP
- 2016-04-01 09:59:45
- date last changed
- 2024-01-06 05:12:34
@article{55666bc2-3b12-489a-8c66-28875a7d30b0,
abstract = {{Background/Aims: Chronic kidney disease (CKD) is common in the general population, may lead to end-stage renal disease, and is most frequently found among males. Familial clustering of kidney diseases has been observed. We aimed to study a potential association between the family history of myocardial infarction (MI) and renal dysfunction. Methods: 22,297 males and 10,828 females, aged 33-60 years, from a population-based cohort study were studied. Estimated glomerular filtration rate (eGFR) was assessed by the CKD-EPI creatinine equation. Every participant filled in a self-administered questionnaire including family history. Heredity for MI was defined as mother or father having had MI and/or died from MI, and/or brother or sister having had MI. Binary logistic regression and multiple linear regression were used in the analyses. Results: Multiple linear regression revealed a significantly increased risk of renal dysfunction in those with a positive heredity for MI (the whole cohort p = 0.01, males p = 0.000, females p = 0.169). Binary logistic regression showed that males with heredity for MI with a mean age of 43 years have a 2 times higher risk (p = 0.02) of belonging to the group with GFR <45 ml/min/1.73 m(2) compared to those without heredity. For the whole cohort the increased risk was 1.6 times (p = 0.07). There was no significant association for females (p = 0.88). Conclusion: These findings demonstrate that a familial burden of MI is associated with renal dysfunction, in men, already in middle age. Genetic variants may underlie predisposition to CKD in those with heredity for MI. © 2014 S. Karger AG, Basel.}},
author = {{Christensson, Anders and Melander, Olle and Fjellstedt, Erik and Ohlson Andersson, Maria}},
issn = {{1421-9670}},
language = {{eng}},
number = {{2}},
pages = {{85--91}},
publisher = {{Karger}},
series = {{American Journal of Nephrology}},
title = {{Family History of Myocardial Infarction Increases Risk of Renal Dysfunction in Middle Age.}},
url = {{https://lup.lub.lu.se/search/files/1461950/4695908.pdf}},
doi = {{10.1159/000358259}},
volume = {{39}},
year = {{2014}},
}