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A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.

Waldhuber, Anna ; Snyder, Greg A ; Römmler, Franziska ; Cirl, Christine ; Müller, Tina ; Xiao, Tsan Sam ; Svanborg, Catharina LU and Miethke, Thomas (2016) In Pathogens 5(25). p.1-8
Abstract
The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters.
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Pathogens
volume
5
issue
25
pages
1 - 8
publisher
MDPI AG
external identifiers
  • pmid:26938564
  • wos:000373680700015
  • pmid:26938564
  • scopus:85009196010
ISSN
2076-0817
DOI
10.3390/pathogens5010025
language
English
LU publication?
yes
id
43614675-2ea6-40da-aca2-9c4c35831e51 (old id 8856374)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26938564?dopt=Abstract
date added to LUP
2016-04-01 15:03:36
date last changed
2022-04-22 06:36:44
@article{43614675-2ea6-40da-aca2-9c4c35831e51,
  abstract     = {{The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters.}},
  author       = {{Waldhuber, Anna and Snyder, Greg A and Römmler, Franziska and Cirl, Christine and Müller, Tina and Xiao, Tsan Sam and Svanborg, Catharina and Miethke, Thomas}},
  issn         = {{2076-0817}},
  language     = {{eng}},
  number       = {{25}},
  pages        = {{1--8}},
  publisher    = {{MDPI AG}},
  series       = {{Pathogens}},
  title        = {{A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.}},
  url          = {{https://lup.lub.lu.se/search/files/4317137/8860332.pdf}},
  doi          = {{10.3390/pathogens5010025}},
  volume       = {{5}},
  year         = {{2016}},
}