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A morphometric magnetic resonance method for measuring cranial, facial and brain characteristics for application to schizophrenia: Part 1.

Henriksson, Karin LU ; Kelly, Brendan D ; Lane, Abbie ; Hult, Roger ; McNeil, Thomas LU and Agartz, Ingrid (2006) In Psychiatry Research: Neuroimaging 147(2-3). p.173-186
Abstract
Serious psychopathology in adulthood may be associated with disturbed foetal brain development, which potentially shows lingering “fossil marks” in the cranial and facial regions. Several methods exist for assessing external craniofacial and internal brain distances but, to our knowledge, no method yet provides simultaneous measurement of cranial, facial and brain dimensions in live subjects. In this article we describe a method to identify landmarks on magnetic resonance images (MRI) for simultaneous measurement of cranial, facial and brain characteristics potentially associated with psychosis. To test the method itself, 30 patients with chronic schizophrenia and 31 healthy comparison subjects, mean age 41 years, were randomly selected... (More)
Serious psychopathology in adulthood may be associated with disturbed foetal brain development, which potentially shows lingering “fossil marks” in the cranial and facial regions. Several methods exist for assessing external craniofacial and internal brain distances but, to our knowledge, no method yet provides simultaneous measurement of cranial, facial and brain dimensions in live subjects. In this article we describe a method to identify landmarks on magnetic resonance images (MRI) for simultaneous measurement of cranial, facial and brain characteristics potentially associated with psychosis. To test the method itself, 30 patients with chronic schizophrenia and 31 healthy comparison subjects, mean age 41 years, were randomly selected from a larger cohort recruited at the Karolinska Hospital, Sweden. Participants were investigated with MRI, and 60 landmarks in the cranial, facial and brain regions were identified in the images. An independent anthropometric examination measured external craniofacial characteristics for study in relation to measurements produced through MRI. High inter-scorer and re-test reliabilities were obtained for two independent scorers of the landmarks in the MR images. Measurements of potentially comparable craniofacial distances showed high alignment with an established anthropometric method. This new method can provide simultaneous investigation of multiple aspects of cranial, facial and brain morphology in MR images originally collected for other purposes. In a second article we will use this method to compare 3D craniofacial measurements and shape between schizophrenia patients and healthy controls. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
brain, magnetic resonance imaging, craniofacial landmarks, morphometry, schizophrenia
in
Psychiatry Research: Neuroimaging
volume
147
issue
2-3
pages
173 - 186
publisher
Elsevier
external identifiers
  • wos:000241326800009
  • scopus:33748690948
  • pmid:16952447
ISSN
0925-4927
DOI
10.1016/j.pscychresns.2005.02.013
language
English
LU publication?
yes
id
43729b54-d0be-45e7-ae55-a7d71c2d2b45 (old id 161226)
date added to LUP
2016-04-01 11:46:05
date last changed
2020-01-12 08:34:12
@article{43729b54-d0be-45e7-ae55-a7d71c2d2b45,
  abstract     = {Serious psychopathology in adulthood may be associated with disturbed foetal brain development, which potentially shows lingering “fossil marks” in the cranial and facial regions. Several methods exist for assessing external craniofacial and internal brain distances but, to our knowledge, no method yet provides simultaneous measurement of cranial, facial and brain dimensions in live subjects. In this article we describe a method to identify landmarks on magnetic resonance images (MRI) for simultaneous measurement of cranial, facial and brain characteristics potentially associated with psychosis. To test the method itself, 30 patients with chronic schizophrenia and 31 healthy comparison subjects, mean age 41 years, were randomly selected from a larger cohort recruited at the Karolinska Hospital, Sweden. Participants were investigated with MRI, and 60 landmarks in the cranial, facial and brain regions were identified in the images. An independent anthropometric examination measured external craniofacial characteristics for study in relation to measurements produced through MRI. High inter-scorer and re-test reliabilities were obtained for two independent scorers of the landmarks in the MR images. Measurements of potentially comparable craniofacial distances showed high alignment with an established anthropometric method. This new method can provide simultaneous investigation of multiple aspects of cranial, facial and brain morphology in MR images originally collected for other purposes. In a second article we will use this method to compare 3D craniofacial measurements and shape between schizophrenia patients and healthy controls.},
  author       = {Henriksson, Karin and Kelly, Brendan D and Lane, Abbie and Hult, Roger and McNeil, Thomas and Agartz, Ingrid},
  issn         = {0925-4927},
  language     = {eng},
  number       = {2-3},
  pages        = {173--186},
  publisher    = {Elsevier},
  series       = {Psychiatry Research: Neuroimaging},
  title        = {A morphometric magnetic resonance method for measuring cranial, facial and brain characteristics for application to schizophrenia: Part 1.},
  url          = {http://dx.doi.org/10.1016/j.pscychresns.2005.02.013},
  doi          = {10.1016/j.pscychresns.2005.02.013},
  volume       = {147},
  year         = {2006},
}