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Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin.

Olsen, O E; Wader, K F; Misund, K; Våtsveen, T K; Rø, T B; Mylin, A K; Turesson, Ingemar LU ; Størdal, B F; Moen, S H and Standal, T, et al. (2014) In Blood Cancer Journal 4(Mar 21). p.196-196
Abstract
Multiple myeloma is a malignancy of plasma cells predominantly located in the bone marrow. A number of bone morphogenetic proteins (BMPs) induce apoptosis in myeloma cells in vitro, and with this study we add BMP-9 to the list. BMP-9 has been found in human serum at concentrations that inhibit cancer cell growth in vitro. We here show that the level of BMP-9 in serum was elevated in myeloma patients (median 176 pg/ml, range 8-809) compared with healthy controls (median 110 pg/ml, range 8-359). BMP-9 was also present in the bone marrow and was able to induce apoptosis in 4 out of 11 primary myeloma cell samples by signaling through ALK2. BMP-9-induced apoptosis in myeloma cells was associated with c-MYC downregulation. The effects of BMP-9... (More)
Multiple myeloma is a malignancy of plasma cells predominantly located in the bone marrow. A number of bone morphogenetic proteins (BMPs) induce apoptosis in myeloma cells in vitro, and with this study we add BMP-9 to the list. BMP-9 has been found in human serum at concentrations that inhibit cancer cell growth in vitro. We here show that the level of BMP-9 in serum was elevated in myeloma patients (median 176 pg/ml, range 8-809) compared with healthy controls (median 110 pg/ml, range 8-359). BMP-9 was also present in the bone marrow and was able to induce apoptosis in 4 out of 11 primary myeloma cell samples by signaling through ALK2. BMP-9-induced apoptosis in myeloma cells was associated with c-MYC downregulation. The effects of BMP-9 were counteracted by membrane-bound (CD105) or soluble endoglin present in the bone marrow microenvironment, suggesting a mechanism for how myeloma cells can evade the tumor suppressing activity of BMP-9 in multiple myeloma. (Less)
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Contribution to journal
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published
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Blood Cancer Journal
volume
4
issue
Mar 21
pages
196 - 196
publisher
Nature Publishing Group
external identifiers
  • pmid:24658374
  • wos:000334494800008
  • scopus:84901840766
ISSN
2044-5385
DOI
10.1038/bcj.2014.16
language
English
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yes
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5ea4548b-0431-4702-9353-38f4ec17b6ed (old id 4379870)
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http://www.ncbi.nlm.nih.gov/pubmed/24658374?dopt=Abstract
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2014-04-03 21:06:54
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2017-10-22 04:07:27
@article{5ea4548b-0431-4702-9353-38f4ec17b6ed,
  abstract     = {Multiple myeloma is a malignancy of plasma cells predominantly located in the bone marrow. A number of bone morphogenetic proteins (BMPs) induce apoptosis in myeloma cells in vitro, and with this study we add BMP-9 to the list. BMP-9 has been found in human serum at concentrations that inhibit cancer cell growth in vitro. We here show that the level of BMP-9 in serum was elevated in myeloma patients (median 176 pg/ml, range 8-809) compared with healthy controls (median 110 pg/ml, range 8-359). BMP-9 was also present in the bone marrow and was able to induce apoptosis in 4 out of 11 primary myeloma cell samples by signaling through ALK2. BMP-9-induced apoptosis in myeloma cells was associated with c-MYC downregulation. The effects of BMP-9 were counteracted by membrane-bound (CD105) or soluble endoglin present in the bone marrow microenvironment, suggesting a mechanism for how myeloma cells can evade the tumor suppressing activity of BMP-9 in multiple myeloma.},
  author       = {Olsen, O E and Wader, K F and Misund, K and Våtsveen, T K and Rø, T B and Mylin, A K and Turesson, Ingemar and Størdal, B F and Moen, S H and Standal, T and Waage, A and Sundan, A and Holien, T},
  issn         = {2044-5385},
  language     = {eng},
  number       = {Mar 21},
  pages        = {196--196},
  publisher    = {Nature Publishing Group},
  series       = {Blood Cancer Journal},
  title        = {Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin.},
  url          = {http://dx.doi.org/10.1038/bcj.2014.16},
  volume       = {4},
  year         = {2014},
}