Elastin-Like Recombinamers As Smart Drug Delivery Systems
Arias, F Javier ; Santos, Mercedes ; Ibanez-Fonseca, Arturo LU
; Pina, Maria Jesus
and Serrano, Sofía
(2018)
In Current drug targets
19(4).
p.360-379
- Abstract
BACKGROUND: Drug delivery systems that are able to control the release of bioactive molecules and designed to carry drugs to target sites are of particular interest for tissue therapy. Moreover, systems comprising materials that can respond to environmental stimuli and promote self-assembly and higher order supramolecular organization are especially useful in the biomedical field. Objetive: This review focuses on biomaterials suitable for this purpose and that include elastin-like recombinamers (ELRs), a class of proteinaceous polymers bioinspired by natural elastin, designed using recombinant technologies. The self-assembly and thermoresponsive behaviour of these systems, along with their biodegradability, biocompatibility and... (More)
BACKGROUND: Drug delivery systems that are able to control the release of bioactive molecules and designed to carry drugs to target sites are of particular interest for tissue therapy. Moreover, systems comprising materials that can respond to environmental stimuli and promote self-assembly and higher order supramolecular organization are especially useful in the biomedical field. Objetive: This review focuses on biomaterials suitable for this purpose and that include elastin-like recombinamers (ELRs), a class of proteinaceous polymers bioinspired by natural elastin, designed using recombinant technologies. The self-assembly and thermoresponsive behaviour of these systems, along with their biodegradability, biocompatibility and well-defined composition as a result of their tailormade design, make them particularly attractive for controlled drug delivery.
RESULTS: ELR-based delivery systems that allow targeted delivery are reviewed, especially ELR-drug recombinant fusion constructs, ELR-drug systems chemically bioconjugated in their monomeric and soluble forms, and drug encapsulation by nanoparticle-forming ELRs. Subsequently, the review focuses on those drug carriers in which smart release is triggered by pH or temperature with a particular focus on cancer treatments. Systems for controlled drug release based on depots and hydrogels that act as both a support and reservoir in which drugs can be stored will be described, and their applications in drug delivery discussed. Finally, smart drug-delivery systems not based on ELRs, including those comprising proteins, synthetic polymers and non-polymeric systems, will also be briefly discussed.
CONCLUSION: Several different constructions based on ELRs are potential candidates for controlled drug delivery to be applied in advanced biomedical treatments.
(Less)
- author
- Arias, F Javier
; Santos, Mercedes
; Ibanez-Fonseca, Arturo
LU
; Pina, Maria Jesus
and Serrano, Sofía
- publishing date
- 2018-02-19
- type
- Contribution to journal
- publication status
- published
- keywords
- Biocompatible Materials/chemistry, Drug Carriers/chemistry, Drug Delivery Systems/methods, Elastin/chemistry, Humans, Nanoparticles/chemistry, Polymers/chemistry
- in
- Current drug targets
- volume
- 19
- issue
- 4
- pages
- 360 - 379
- publisher
- Bentham Science Publishers
- external identifiers
-
- pmid:26844559
- scopus:85010380282
- ISSN
- 1873-5592
- DOI
- 10.2174/1389450117666160201114617
- language
- English
- LU publication?
- no
- additional info
- Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
- id
- 437ff5b6-29c7-4059-851f-c6911ff5eceb
- date added to LUP
- 2025-09-14 19:41:46
- date last changed
- 2025-11-24 10:21:59
@article{437ff5b6-29c7-4059-851f-c6911ff5eceb,
abstract = {{<p>BACKGROUND: Drug delivery systems that are able to control the release of bioactive molecules and designed to carry drugs to target sites are of particular interest for tissue therapy. Moreover, systems comprising materials that can respond to environmental stimuli and promote self-assembly and higher order supramolecular organization are especially useful in the biomedical field. Objetive: This review focuses on biomaterials suitable for this purpose and that include elastin-like recombinamers (ELRs), a class of proteinaceous polymers bioinspired by natural elastin, designed using recombinant technologies. The self-assembly and thermoresponsive behaviour of these systems, along with their biodegradability, biocompatibility and well-defined composition as a result of their tailormade design, make them particularly attractive for controlled drug delivery.</p><p>RESULTS: ELR-based delivery systems that allow targeted delivery are reviewed, especially ELR-drug recombinant fusion constructs, ELR-drug systems chemically bioconjugated in their monomeric and soluble forms, and drug encapsulation by nanoparticle-forming ELRs. Subsequently, the review focuses on those drug carriers in which smart release is triggered by pH or temperature with a particular focus on cancer treatments. Systems for controlled drug release based on depots and hydrogels that act as both a support and reservoir in which drugs can be stored will be described, and their applications in drug delivery discussed. Finally, smart drug-delivery systems not based on ELRs, including those comprising proteins, synthetic polymers and non-polymeric systems, will also be briefly discussed.</p><p>CONCLUSION: Several different constructions based on ELRs are potential candidates for controlled drug delivery to be applied in advanced biomedical treatments.</p>}},
author = {{Arias, F Javier and Santos, Mercedes and Ibanez-Fonseca, Arturo and Pina, Maria Jesus and Serrano, Sofía}},
issn = {{1873-5592}},
keywords = {{Biocompatible Materials/chemistry; Drug Carriers/chemistry; Drug Delivery Systems/methods; Elastin/chemistry; Humans; Nanoparticles/chemistry; Polymers/chemistry}},
language = {{eng}},
month = {{02}},
number = {{4}},
pages = {{360--379}},
publisher = {{Bentham Science Publishers}},
series = {{Current drug targets}},
title = {{Elastin-Like Recombinamers As Smart Drug Delivery Systems}},
url = {{http://dx.doi.org/10.2174/1389450117666160201114617}},
doi = {{10.2174/1389450117666160201114617}},
volume = {{19}},
year = {{2018}},
}