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Distribution pattern of the Ki67 labelling index in breast cancer and its implications for choosing cut-off values.

Cserni, Gábor; Vörös, András; Liepniece-Karele, Inta; Bianchi, Simonetta; Vezzosi, Vania; Grabau, Dorthe LU ; Sapino, Anna; Castellano, Isabella; Regitnig, Peter and Foschini, Maria Pia, et al. (2014) In Breast 23(3). p.259-263
Abstract
The Ki67 labelling index (LI - proportion of staining cells) is widely used to reflect proliferation in breast carcinomas. Several cut-off values have been suggested to distinguish between tumours with low and high proliferative activity. The aim of the current study was to evaluate the distribution of Ki67 LIs in breast carcinomas diagnosed at different institutions by different pathologists using the method reflecting their daily practice. Pathologists using Ki67 were asked to provide data (including the LI, type of the specimen, receptor status, grade) on 100 consecutively stained cases, as well as details of their evaluation. A full dataset of 1709 carcinomas was collected from 19 departments. The median Ki67 LI was 17% for all tumours... (More)
The Ki67 labelling index (LI - proportion of staining cells) is widely used to reflect proliferation in breast carcinomas. Several cut-off values have been suggested to distinguish between tumours with low and high proliferative activity. The aim of the current study was to evaluate the distribution of Ki67 LIs in breast carcinomas diagnosed at different institutions by different pathologists using the method reflecting their daily practice. Pathologists using Ki67 were asked to provide data (including the LI, type of the specimen, receptor status, grade) on 100 consecutively stained cases, as well as details of their evaluation. A full dataset of 1709 carcinomas was collected from 19 departments. The median Ki67 LI was 17% for all tumours and 14% for oestrogen receptor-positive and HER2-negative carcinomas. Tumours with higher mitotic counts were associated with higher Ki67 LIs. Ki67 LIs tended to cluster around values ending with 5 or 0 both in cases where the values were obtained by counting the proportion of stained tumour cell nuclei and those where the values were obtained by estimation. On the basis of the distribution pattern described, some currently used Ki67 LI cut off values are not realistic, and it is proposed to select more realistic values ending with 0 or 5. (Less)
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Contribution to journal
publication status
published
subject
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Breast
volume
23
issue
3
pages
259 - 263
publisher
Churchill Livingstone
external identifiers
  • pmid:24613255
  • wos:000335509600009
  • scopus:84899907977
ISSN
1532-3080
DOI
10.1016/j.breast.2014.02.003
language
English
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yes
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dfbacd61-83c2-4cc2-bd50-43d50fef01a2 (old id 4383538)
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http://www.ncbi.nlm.nih.gov/pubmed/24613255?dopt=Abstract
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2014-04-02 21:31:51
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2017-11-19 03:12:09
@article{dfbacd61-83c2-4cc2-bd50-43d50fef01a2,
  abstract     = {The Ki67 labelling index (LI - proportion of staining cells) is widely used to reflect proliferation in breast carcinomas. Several cut-off values have been suggested to distinguish between tumours with low and high proliferative activity. The aim of the current study was to evaluate the distribution of Ki67 LIs in breast carcinomas diagnosed at different institutions by different pathologists using the method reflecting their daily practice. Pathologists using Ki67 were asked to provide data (including the LI, type of the specimen, receptor status, grade) on 100 consecutively stained cases, as well as details of their evaluation. A full dataset of 1709 carcinomas was collected from 19 departments. The median Ki67 LI was 17% for all tumours and 14% for oestrogen receptor-positive and HER2-negative carcinomas. Tumours with higher mitotic counts were associated with higher Ki67 LIs. Ki67 LIs tended to cluster around values ending with 5 or 0 both in cases where the values were obtained by counting the proportion of stained tumour cell nuclei and those where the values were obtained by estimation. On the basis of the distribution pattern described, some currently used Ki67 LI cut off values are not realistic, and it is proposed to select more realistic values ending with 0 or 5.},
  author       = {Cserni, Gábor and Vörös, András and Liepniece-Karele, Inta and Bianchi, Simonetta and Vezzosi, Vania and Grabau, Dorthe and Sapino, Anna and Castellano, Isabella and Regitnig, Peter and Foschini, Maria Pia and Zolota, Vassiliki and Varga, Zsuzsanna and Figueiredo, Paulo and Decker, Thomas and Focke, Cornelia and Kulka, Janina and Kaya, Handan and Reiner-Concin, Angelika and Amendoeira, Isabel and Callagy, Grace and Caffrey, Emer and Wesseling, Jelle and Wells, Clive},
  issn         = {1532-3080},
  language     = {eng},
  number       = {3},
  pages        = {259--263},
  publisher    = {Churchill Livingstone},
  series       = {Breast},
  title        = {Distribution pattern of the Ki67 labelling index in breast cancer and its implications for choosing cut-off values.},
  url          = {http://dx.doi.org/10.1016/j.breast.2014.02.003},
  volume       = {23},
  year         = {2014},
}