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Reversal of stroke induced lymphocytopenia by levodopa/benserazide treatment.

Kuric, Enida LU and Ruscher, Karsten LU (2014) In Journal of Neuroimmunology 269(1-2). p.94-97
Abstract
Evidences exist that dopamine is involved in T-cell homeostasis. Here, we investigated if daily treatment with levodopa (20mg/kg)/benserazide (15mg/kg) regulates the number of T-cells in the blood of Sprague Dawley rats subjected to transient occlusion of the middle cerebral artery (tMCAO). T-cells and associated inflammatory cytokines were analyzed in the blood one week after tMCAO. Treatment with levodopa/benserazide completely recovered T-helper cell depletion in animals subjected to tMCAO whereas T-cell associated cytokines remained unaffected after stroke, however, cytokines were downregulated in levodopa treated sham operated animals. Together, we demonstrate that dopamine has beneficial effects on poststroke immunodepression.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neuroimmunology
volume
269
issue
1-2
pages
94 - 97
publisher
Elsevier
external identifiers
  • pmid:24613254
  • wos:000335428000014
  • scopus:84896402591
ISSN
1872-8421
DOI
10.1016/j.jneuroim.2014.02.009
language
English
LU publication?
yes
id
5181718c-7525-49c6-955e-e49e7c742157 (old id 4383564)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24613254?dopt=Abstract
date added to LUP
2014-04-02 21:33:23
date last changed
2017-01-01 03:38:47
@article{5181718c-7525-49c6-955e-e49e7c742157,
  abstract     = {Evidences exist that dopamine is involved in T-cell homeostasis. Here, we investigated if daily treatment with levodopa (20mg/kg)/benserazide (15mg/kg) regulates the number of T-cells in the blood of Sprague Dawley rats subjected to transient occlusion of the middle cerebral artery (tMCAO). T-cells and associated inflammatory cytokines were analyzed in the blood one week after tMCAO. Treatment with levodopa/benserazide completely recovered T-helper cell depletion in animals subjected to tMCAO whereas T-cell associated cytokines remained unaffected after stroke, however, cytokines were downregulated in levodopa treated sham operated animals. Together, we demonstrate that dopamine has beneficial effects on poststroke immunodepression.},
  author       = {Kuric, Enida and Ruscher, Karsten},
  issn         = {1872-8421},
  language     = {eng},
  number       = {1-2},
  pages        = {94--97},
  publisher    = {Elsevier},
  series       = {Journal of Neuroimmunology},
  title        = {Reversal of stroke induced lymphocytopenia by levodopa/benserazide treatment.},
  url          = {http://dx.doi.org/10.1016/j.jneuroim.2014.02.009},
  volume       = {269},
  year         = {2014},
}