Reversal of stroke induced lymphocytopenia by levodopa/benserazide treatment.
(2014) In Journal of Neuroimmunology 269(1-2). p.94-97- Abstract
- Evidences exist that dopamine is involved in T-cell homeostasis. Here, we investigated if daily treatment with levodopa (20mg/kg)/benserazide (15mg/kg) regulates the number of T-cells in the blood of Sprague Dawley rats subjected to transient occlusion of the middle cerebral artery (tMCAO). T-cells and associated inflammatory cytokines were analyzed in the blood one week after tMCAO. Treatment with levodopa/benserazide completely recovered T-helper cell depletion in animals subjected to tMCAO whereas T-cell associated cytokines remained unaffected after stroke, however, cytokines were downregulated in levodopa treated sham operated animals. Together, we demonstrate that dopamine has beneficial effects on poststroke immunodepression.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4383564
- author
- Kuric, Enida LU and Ruscher, Karsten LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neuroimmunology
- volume
- 269
- issue
- 1-2
- pages
- 94 - 97
- publisher
- Elsevier
- external identifiers
-
- pmid:24613254
- wos:000335428000014
- scopus:84896402591
- ISSN
- 1872-8421
- DOI
- 10.1016/j.jneuroim.2014.02.009
- language
- English
- LU publication?
- yes
- id
- 5181718c-7525-49c6-955e-e49e7c742157 (old id 4383564)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24613254?dopt=Abstract
- date added to LUP
- 2016-04-01 10:29:56
- date last changed
- 2022-02-02 18:24:33
@article{5181718c-7525-49c6-955e-e49e7c742157,
abstract = {{Evidences exist that dopamine is involved in T-cell homeostasis. Here, we investigated if daily treatment with levodopa (20mg/kg)/benserazide (15mg/kg) regulates the number of T-cells in the blood of Sprague Dawley rats subjected to transient occlusion of the middle cerebral artery (tMCAO). T-cells and associated inflammatory cytokines were analyzed in the blood one week after tMCAO. Treatment with levodopa/benserazide completely recovered T-helper cell depletion in animals subjected to tMCAO whereas T-cell associated cytokines remained unaffected after stroke, however, cytokines were downregulated in levodopa treated sham operated animals. Together, we demonstrate that dopamine has beneficial effects on poststroke immunodepression.}},
author = {{Kuric, Enida and Ruscher, Karsten}},
issn = {{1872-8421}},
language = {{eng}},
number = {{1-2}},
pages = {{94--97}},
publisher = {{Elsevier}},
series = {{Journal of Neuroimmunology}},
title = {{Reversal of stroke induced lymphocytopenia by levodopa/benserazide treatment.}},
url = {{http://dx.doi.org/10.1016/j.jneuroim.2014.02.009}},
doi = {{10.1016/j.jneuroim.2014.02.009}},
volume = {{269}},
year = {{2014}},
}