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microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons.

Åkerblom, Malin LU ; Petri, Rebecca LU ; Sachdeva, Rohit LU ; Klüssendorf, Thies LU ; Mattsson, Bengt LU ; Gentner, Bernhard and Jakobsson, Johan LU (2014) In Development 141(7). p.1580-1588
Abstract
New neurons, originating from the subventricular zone, are continuously integrating into neuronal circuitry in the olfactory bulb (OB). Using a transgenic sensor mouse, we found that adult-born OB interneurons express microRNA-125 (miR-125), whereas the pre-existing developmentally generated OB interneurons represent a unique population of cells in the adult brain, without miR-125 activity. Stable inhibition of miR-125 in newborn OB neurons resulted in enhanced dendritic morphogenesis, as well as in increased synaptic activation in response to odour sensory stimuli. These data demonstrate that miR-125 controls functional synaptic integration of adult-born OB interneurons. Our results also suggest that absence of an otherwise broadly... (More)
New neurons, originating from the subventricular zone, are continuously integrating into neuronal circuitry in the olfactory bulb (OB). Using a transgenic sensor mouse, we found that adult-born OB interneurons express microRNA-125 (miR-125), whereas the pre-existing developmentally generated OB interneurons represent a unique population of cells in the adult brain, without miR-125 activity. Stable inhibition of miR-125 in newborn OB neurons resulted in enhanced dendritic morphogenesis, as well as in increased synaptic activation in response to odour sensory stimuli. These data demonstrate that miR-125 controls functional synaptic integration of adult-born OB interneurons. Our results also suggest that absence of an otherwise broadly expressed miRNA is a novel mechanism with which to achieve neuronal subtype specification. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Development
volume
141
issue
7
pages
1580 - 1588
publisher
Society for International Development
external identifiers
  • pmid:24598163
  • wos:000333184500017
  • scopus:84896271384
ISSN
1477-9129
DOI
10.1242/dev.101659
language
English
LU publication?
yes
id
3b287be7-9679-4160-a5bd-4fc0ce200cc7 (old id 4383839)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24598163?dopt=Abstract
date added to LUP
2014-04-02 18:56:10
date last changed
2017-11-05 03:05:54
@article{3b287be7-9679-4160-a5bd-4fc0ce200cc7,
  abstract     = {New neurons, originating from the subventricular zone, are continuously integrating into neuronal circuitry in the olfactory bulb (OB). Using a transgenic sensor mouse, we found that adult-born OB interneurons express microRNA-125 (miR-125), whereas the pre-existing developmentally generated OB interneurons represent a unique population of cells in the adult brain, without miR-125 activity. Stable inhibition of miR-125 in newborn OB neurons resulted in enhanced dendritic morphogenesis, as well as in increased synaptic activation in response to odour sensory stimuli. These data demonstrate that miR-125 controls functional synaptic integration of adult-born OB interneurons. Our results also suggest that absence of an otherwise broadly expressed miRNA is a novel mechanism with which to achieve neuronal subtype specification.},
  author       = {Åkerblom, Malin and Petri, Rebecca and Sachdeva, Rohit and Klüssendorf, Thies and Mattsson, Bengt and Gentner, Bernhard and Jakobsson, Johan},
  issn         = {1477-9129},
  language     = {eng},
  number       = {7},
  pages        = {1580--1588},
  publisher    = {Society for International Development},
  series       = {Development},
  title        = {microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons.},
  url          = {http://dx.doi.org/10.1242/dev.101659},
  volume       = {141},
  year         = {2014},
}