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Atrial natriuretic Peptide and type 2 diabetes development - biomarker and genotype association study.

Jujic, Amra LU ; Nilsson, Peter LU ; Engström, Gunnar LU ; Hedblad, Bo LU ; Melander, Olle LU and Magnusson, Martin LU (2014) In PLoS ONE 9(2).
Abstract
We have recently shown that low plasma levels of mid-regional atrial natriuretic peptide (MR-ANP) predict development of diabetes and glucose progression over time, independently of known risk factors for diabetes development. However, since MR-ANP levels might be influenced by unknown factors causing diabetes, we cannot rule out that such relationship might be confounded. Previous studies have shown an association of a single nucleotide polymorphism rs5068 on the natriuretic peptide precursor A (NPPA) locus gene with higher levels of circulating ANP. Since gene variants are inherited randomly and not subject to confounding, we aimed to investigate whether the variant rs5068 within the NPPA locus is associated with incident type 2 diabetes.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
9
issue
2
publisher
Public Library of Science
external identifiers
  • pmid:24586593
  • wos:000331711900103
  • scopus:84896750943
ISSN
1932-6203
DOI
10.1371/journal.pone.0089201
language
English
LU publication?
yes
id
f85f6525-b864-48e1-acc2-d13083e4cebc (old id 4384156)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24586593?dopt=Abstract
date added to LUP
2014-04-01 19:05:14
date last changed
2017-11-12 03:37:29
@article{f85f6525-b864-48e1-acc2-d13083e4cebc,
  abstract     = {We have recently shown that low plasma levels of mid-regional atrial natriuretic peptide (MR-ANP) predict development of diabetes and glucose progression over time, independently of known risk factors for diabetes development. However, since MR-ANP levels might be influenced by unknown factors causing diabetes, we cannot rule out that such relationship might be confounded. Previous studies have shown an association of a single nucleotide polymorphism rs5068 on the natriuretic peptide precursor A (NPPA) locus gene with higher levels of circulating ANP. Since gene variants are inherited randomly and not subject to confounding, we aimed to investigate whether the variant rs5068 within the NPPA locus is associated with incident type 2 diabetes.},
  articleno    = {e89201},
  author       = {Jujic, Amra and Nilsson, Peter and Engström, Gunnar and Hedblad, Bo and Melander, Olle and Magnusson, Martin},
  issn         = {1932-6203},
  language     = {eng},
  number       = {2},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Atrial natriuretic Peptide and type 2 diabetes development - biomarker and genotype association study.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0089201},
  volume       = {9},
  year         = {2014},
}