Advanced

Inverse correlation of valproic acid serum concentrations and quality of life in adolescents with epilepsy

Jakovljevic, Mihajlo B LU ; Jankovic, Slobodan M; Jankovic, Snezana V and Todorovic, Natalija (2008) In Epilepsy Research 80(2-3). p.3-180
Abstract

BACKGROUND: Correlation between steady-state serum concentrations of antiepileptic drugs and both seizure control and adverse drug reactions frequency (two major determinants of quality of life in patients with epilepsy) is still matter of controversy.

OBJECTIVE: The aim of our study was to investigate whether a correlation exists between steady-state serum concentration of valproic acid and quality of life in adolescent patients with epilepsy.

METHOD: Twenty-one adolescent patients with epilepsy, treated with valproic acid for more than 6 months entered the study. On two occasions, 3 months apart, both through and 2-h-after-the-dose serum concentrations of valproic acid were measured, as well as quality of life, using... (More)

BACKGROUND: Correlation between steady-state serum concentrations of antiepileptic drugs and both seizure control and adverse drug reactions frequency (two major determinants of quality of life in patients with epilepsy) is still matter of controversy.

OBJECTIVE: The aim of our study was to investigate whether a correlation exists between steady-state serum concentration of valproic acid and quality of life in adolescent patients with epilepsy.

METHOD: Twenty-one adolescent patients with epilepsy, treated with valproic acid for more than 6 months entered the study. On two occasions, 3 months apart, both through and 2-h-after-the-dose serum concentrations of valproic acid were measured, as well as quality of life, using QOLIE-AD-48 for adolescents. Adverse drug reactions and seizure control were also recorded.

RESULTS: Significant inverse correlation between through serum concentrations of valproic acid and total QOLIE-AD-48 scores was observed, together with correlation between through serum concentrations and adverse drug reactions frequency. The scores of memory/concentration and physical functioning QOLIEAD-48 domains were significantly and inversely correlated with through serum concentrations.

CONCLUSION: Our study suggests that therapeutic monitoring of valproic acid serum concentrations could be useful predictor and marker of the most important epilepsy treatment outcome--quality of life.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
keywords
Adolescent, Adult, Anticonvulsants/blood, Child, Epilepsy/blood, Female, Humans, Male, Quality of Life, Statistics as Topic, Time Factors, Valproic Acid/blood
in
Epilepsy Research
volume
80
issue
2-3
pages
3 - 180
publisher
Elsevier
external identifiers
  • scopus:47649093637
ISSN
0920-1211
DOI
10.1016/j.eplepsyres.2008.04.006
language
English
LU publication?
no
id
438c59bc-f638-45ad-b5d7-884257c18d9b
date added to LUP
2018-09-01 23:11:25
date last changed
2019-02-20 11:25:33
@article{438c59bc-f638-45ad-b5d7-884257c18d9b,
  abstract     = {<p>BACKGROUND: Correlation between steady-state serum concentrations of antiepileptic drugs and both seizure control and adverse drug reactions frequency (two major determinants of quality of life in patients with epilepsy) is still matter of controversy.</p><p>OBJECTIVE: The aim of our study was to investigate whether a correlation exists between steady-state serum concentration of valproic acid and quality of life in adolescent patients with epilepsy.</p><p>METHOD: Twenty-one adolescent patients with epilepsy, treated with valproic acid for more than 6 months entered the study. On two occasions, 3 months apart, both through and 2-h-after-the-dose serum concentrations of valproic acid were measured, as well as quality of life, using QOLIE-AD-48 for adolescents. Adverse drug reactions and seizure control were also recorded.</p><p>RESULTS: Significant inverse correlation between through serum concentrations of valproic acid and total QOLIE-AD-48 scores was observed, together with correlation between through serum concentrations and adverse drug reactions frequency. The scores of memory/concentration and physical functioning QOLIEAD-48 domains were significantly and inversely correlated with through serum concentrations.</p><p>CONCLUSION: Our study suggests that therapeutic monitoring of valproic acid serum concentrations could be useful predictor and marker of the most important epilepsy treatment outcome--quality of life.</p>},
  author       = {Jakovljevic, Mihajlo B and Jankovic, Slobodan M and Jankovic, Snezana V and Todorovic, Natalija},
  issn         = {0920-1211},
  keyword      = {Adolescent,Adult,Anticonvulsants/blood,Child,Epilepsy/blood,Female,Humans,Male,Quality of Life,Statistics as Topic,Time Factors,Valproic Acid/blood},
  language     = {eng},
  number       = {2-3},
  pages        = {3--180},
  publisher    = {Elsevier},
  series       = {Epilepsy Research},
  title        = {Inverse correlation of valproic acid serum concentrations and quality of life in adolescents with epilepsy},
  url          = {http://dx.doi.org/10.1016/j.eplepsyres.2008.04.006},
  volume       = {80},
  year         = {2008},
}