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Neuropeptide Y effector systems : perspectives for drug development

Grundemar, L LU and Håkanson, R LU (1994) In Trends in Pharmacological Sciences 15(5). p.153-159
Abstract

Neuropeptide Y was isolated in 1982 and has since attracted considerable interest. It is widely distributed in central and peripheral neurones and can produce a multitude of biological effects in the brain and the periphery. For example, the peptide has been associated with stimulation of food and water intake, control of mood, and regulation of central autonomic functions. In the periphery, sympathetic neuropeptide Y plays a role as a vasopressor and vasoconstrictor. Neuropeptide Y acts on at least three distinct receptor types, referred to a Y1, Y2 and Y3. This review by Lars Grundemar and Rolf Håkanson focuses on some neuropeptide Y-dependent mechanisms that may be implicated in certain disorders and may be promising targets for... (More)

Neuropeptide Y was isolated in 1982 and has since attracted considerable interest. It is widely distributed in central and peripheral neurones and can produce a multitude of biological effects in the brain and the periphery. For example, the peptide has been associated with stimulation of food and water intake, control of mood, and regulation of central autonomic functions. In the periphery, sympathetic neuropeptide Y plays a role as a vasopressor and vasoconstrictor. Neuropeptide Y acts on at least three distinct receptor types, referred to a Y1, Y2 and Y3. This review by Lars Grundemar and Rolf Håkanson focuses on some neuropeptide Y-dependent mechanisms that may be implicated in certain disorders and may be promising targets for drugs active at neuropeptide Y receptors.

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published
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keywords
Amino Acid Sequence, Animals, Anxiety/drug therapy, Behavior, Animal/drug effects, Drinking/drug effects, Drug Design, Eating/drug effects, Molecular Sequence Data, Neuropeptide Y/chemistry, Rats, Synaptic Transmission/drug effects, Vasoconstriction/drug effects
in
Trends in Pharmacological Sciences
volume
15
issue
5
pages
153 - 159
publisher
Elsevier
external identifiers
  • scopus:0028277938
ISSN
0165-6147
DOI
10.1016/0165-6147(94)90076-0
language
English
LU publication?
yes
id
43936c7d-584e-4b3b-a0d6-552a2b10d951
date added to LUP
2019-09-03 14:03:16
date last changed
2019-09-08 04:43:16
@article{43936c7d-584e-4b3b-a0d6-552a2b10d951,
  abstract     = {<p>Neuropeptide Y was isolated in 1982 and has since attracted considerable interest. It is widely distributed in central and peripheral neurones and can produce a multitude of biological effects in the brain and the periphery. For example, the peptide has been associated with stimulation of food and water intake, control of mood, and regulation of central autonomic functions. In the periphery, sympathetic neuropeptide Y plays a role as a vasopressor and vasoconstrictor. Neuropeptide Y acts on at least three distinct receptor types, referred to a Y1, Y2 and Y3. This review by Lars Grundemar and Rolf Håkanson focuses on some neuropeptide Y-dependent mechanisms that may be implicated in certain disorders and may be promising targets for drugs active at neuropeptide Y receptors.</p>},
  author       = {Grundemar, L and Håkanson, R},
  issn         = {0165-6147},
  keyword      = {Amino Acid Sequence,Animals,Anxiety/drug therapy,Behavior, Animal/drug effects,Drinking/drug effects,Drug Design,Eating/drug effects,Molecular Sequence Data,Neuropeptide Y/chemistry,Rats,Synaptic Transmission/drug effects,Vasoconstriction/drug effects},
  language     = {eng},
  number       = {5},
  pages        = {153--159},
  publisher    = {Elsevier},
  series       = {Trends in Pharmacological Sciences},
  title        = {Neuropeptide Y effector systems : perspectives for drug development},
  url          = {http://dx.doi.org/10.1016/0165-6147(94)90076-0},
  volume       = {15},
  year         = {1994},
}