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Revisiting antibiotic resistance spreading in wastewater treatment plants - Bacteriophages as a much neglected potential transmission vehicle

Lood, Rolf LU ; Ertürk, Gizem LU and Mattiasson, Bo LU (2017) In Frontiers in Microbiology 8(NOV).
Abstract

The spread of antibiotic resistance is currently a major threat to health that humanity is facing today. Novel multidrug and pandrug resistant bacteria are reported on a yearly basis, while the development of novel antibiotics is lacking. Focus to limit the spread of antibiotic resistance by reducing the usage of antibiotics in health care, veterinary applications, and meat production, have been implemented, limiting the exposure of pathogens to antibiotics, thus lowering the selection of resistant strains. Despite these attempts, the global resistance has increased significantly. A recent area of focus has been to limit the spread of resistance through wastewater treatment plants (WWTPs), serving as huge reservoirs of microbes and... (More)

The spread of antibiotic resistance is currently a major threat to health that humanity is facing today. Novel multidrug and pandrug resistant bacteria are reported on a yearly basis, while the development of novel antibiotics is lacking. Focus to limit the spread of antibiotic resistance by reducing the usage of antibiotics in health care, veterinary applications, and meat production, have been implemented, limiting the exposure of pathogens to antibiotics, thus lowering the selection of resistant strains. Despite these attempts, the global resistance has increased significantly. A recent area of focus has been to limit the spread of resistance through wastewater treatment plants (WWTPs), serving as huge reservoirs of microbes and resistance genes. While being able to quite efficiently reduce the presence of resistant bacteria entering any of the final products of WWTPs (e.g., effluent water and sludge), the presence of resistance genes in other formats (mobile genetic elements, bacteriophages) has mainly been ignored. Recent data stress the importance of transduction in WWTPs as a mediator of resistance spread. Here we examine the current literature in the role of WWTPs as reservoirs and hotspots of antibiotic resistance with a specific focus on bacteriophages as mediators of genetic exchange.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antibiotic resistance, Antibiotic resistance genes, Antimicrobial resistance, Bacteriophages, Wastewater treatment, WWTP
in
Frontiers in Microbiology
volume
8
issue
NOV
publisher
Frontiers
external identifiers
  • scopus:85034627797
  • wos:000415794000005
ISSN
1664-302X
DOI
10.3389/fmicb.2017.02298
language
English
LU publication?
yes
id
439b0115-be56-4f22-99d6-8343044ff4a6
date added to LUP
2017-12-14 13:01:30
date last changed
2018-01-16 13:27:51
@article{439b0115-be56-4f22-99d6-8343044ff4a6,
  abstract     = {<p>The spread of antibiotic resistance is currently a major threat to health that humanity is facing today. Novel multidrug and pandrug resistant bacteria are reported on a yearly basis, while the development of novel antibiotics is lacking. Focus to limit the spread of antibiotic resistance by reducing the usage of antibiotics in health care, veterinary applications, and meat production, have been implemented, limiting the exposure of pathogens to antibiotics, thus lowering the selection of resistant strains. Despite these attempts, the global resistance has increased significantly. A recent area of focus has been to limit the spread of resistance through wastewater treatment plants (WWTPs), serving as huge reservoirs of microbes and resistance genes. While being able to quite efficiently reduce the presence of resistant bacteria entering any of the final products of WWTPs (e.g., effluent water and sludge), the presence of resistance genes in other formats (mobile genetic elements, bacteriophages) has mainly been ignored. Recent data stress the importance of transduction in WWTPs as a mediator of resistance spread. Here we examine the current literature in the role of WWTPs as reservoirs and hotspots of antibiotic resistance with a specific focus on bacteriophages as mediators of genetic exchange.</p>},
  articleno    = {2298},
  author       = {Lood, Rolf and Ertürk, Gizem and Mattiasson, Bo},
  issn         = {1664-302X},
  keyword      = {Antibiotic resistance,Antibiotic resistance genes,Antimicrobial resistance,Bacteriophages,Wastewater treatment,WWTP},
  language     = {eng},
  month        = {11},
  number       = {NOV},
  publisher    = {Frontiers},
  series       = {Frontiers in Microbiology},
  title        = {Revisiting antibiotic resistance spreading in wastewater treatment plants - Bacteriophages as a much neglected potential transmission vehicle},
  url          = {http://dx.doi.org/10.3389/fmicb.2017.02298},
  volume       = {8},
  year         = {2017},
}