IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release
(1998) In Mediators of Inflammation 7(3). p.217-220- Abstract
The secretory leukocyte protease inhibitor (SLPI) is a low-molecular- weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.
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- author
- Westin, U. LU ; Lundberg, Eva and Ohlsson, Kjell
- organization
- publishing date
- 1998
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Chymase, Histamine, IgE, Nasal mucosa, SLPI
- in
- Mediators of Inflammation
- volume
- 7
- issue
- 3
- pages
- 217 - 220
- publisher
- Hindawi Limited
- external identifiers
-
- pmid:9705610
- scopus:0031851772
- ISSN
- 0962-9351
- DOI
- 10.1080/09629359891162
- language
- English
- LU publication?
- yes
- id
- 439c736a-5c0b-413e-a2f3-d6ff0c448047
- date added to LUP
- 2017-02-13 16:08:43
- date last changed
- 2025-01-07 06:46:47
@article{439c736a-5c0b-413e-a2f3-d6ff0c448047, abstract = {{<p>The secretory leukocyte protease inhibitor (SLPI) is a low-molecular- weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.</p>}}, author = {{Westin, U. and Lundberg, Eva and Ohlsson, Kjell}}, issn = {{0962-9351}}, keywords = {{Chymase; Histamine; IgE; Nasal mucosa; SLPI}}, language = {{eng}}, number = {{3}}, pages = {{217--220}}, publisher = {{Hindawi Limited}}, series = {{Mediators of Inflammation}}, title = {{IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release}}, url = {{http://dx.doi.org/10.1080/09629359891162}}, doi = {{10.1080/09629359891162}}, volume = {{7}}, year = {{1998}}, }