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IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release

Westin, U. LU ; Lundberg, Eva and Ohlsson, Kjell (1998) In Mediators of Inflammation 7(3). p.217-220
Abstract

The secretory leukocyte protease inhibitor (SLPI) is a low-molecular- weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chymase, Histamine, IgE, Nasal mucosa, SLPI
in
Mediators of Inflammation
volume
7
issue
3
pages
217 - 220
publisher
Hindawi Publishing Corporation
external identifiers
  • scopus:0031851772
ISSN
0962-9351
DOI
10.1080/09629359891162
language
English
LU publication?
yes
id
439c736a-5c0b-413e-a2f3-d6ff0c448047
date added to LUP
2017-02-13 16:08:43
date last changed
2017-02-13 16:08:43
@article{439c736a-5c0b-413e-a2f3-d6ff0c448047,
  abstract     = {<p>The secretory leukocyte protease inhibitor (SLPI) is a low-molecular- weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.</p>},
  author       = {Westin, U. and Lundberg, Eva and Ohlsson, Kjell},
  issn         = {0962-9351},
  keyword      = {Chymase,Histamine,IgE,Nasal mucosa,SLPI},
  language     = {eng},
  number       = {3},
  pages        = {217--220},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Mediators of Inflammation},
  title        = {IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release},
  url          = {http://dx.doi.org/10.1080/09629359891162},
  volume       = {7},
  year         = {1998},
}