Association between Dietary Zinc and Selenium Intake, Oxidative Stress-Related Gene Polymorphism, and Colorectal Cancer Risk in Chinese Population - A Case-Control Study
Luo, Hong ; Fang, Yujing ; Zhang, Xin ; Feng, Xiaoli ; Zhang, Naiqi LU
; Abulimiti, Alinuer
; Huang, Chuyi
and Zhang, Caixia
(2021)
In Nutrition and Cancer
73(9).
p.1621-1630
- Abstract
- Zinc and selenium may protect against colorectal cancer (CRC) progression through their anti-oxidative effects. This study examined the independent and combined effect of dietary zinc and selenium intake, and polymorphisms of the oxidative stress-related genes (superoxide dismutase 1, superoxide dismutase 2, glutathione peroxidase, and catalase) on CRC risk in a Chinese case-control study. A total of 493 cases and 498 sex and age-matched controls were randomly selected from an ongoing case-control study. Dietary information was assessed through face-to-face interviews using a validated food frequency questionnaire. Multiplex PCR-ligase detection reaction was used for genotyping the target SNPs. Multivariable logistic regression was used to... (More)
- Zinc and selenium may protect against colorectal cancer (CRC) progression through their anti-oxidative effects. This study examined the independent and combined effect of dietary zinc and selenium intake, and polymorphisms of the oxidative stress-related genes (superoxide dismutase 1, superoxide dismutase 2, glutathione peroxidase, and catalase) on CRC risk in a Chinese case-control study. A total of 493 cases and 498 sex and age-matched controls were randomly selected from an ongoing case-control study. Dietary information was assessed through face-to-face interviews using a validated food frequency questionnaire. Multiplex PCR-ligase detection reaction was used for genotyping the target SNPs. Multivariable logistic regression was used to estimate the odds ratios (ORs) and 95% confidence interval (CI). Intake of selenium was found to be inversely associated with CRC risk, while zinc was not associated with CRC risk. The ORs (95% CI) for the highest vs. the lowest quartile were 0.42 (95% CI 0.28, 0.64, Ptrend < 0.001) for selenium and 0.96 (95% CI 0.63, 1.47, Ptrend = 0.505) for zinc. Combined effect was observed between zinc and SOD1 rs4998557 on CRC risk (Pinteraction < 0.05). This study identified a novel diet-gene interaction in the oxidative stress pathway on CRC risk in Chinese population. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/43a29e79-3e2d-43cf-8bc4-e67831f179f2
- author
- Luo, Hong
; Fang, Yujing
; Zhang, Xin
; Feng, Xiaoli
; Zhang, Naiqi
LU
; Abulimiti, Alinuer
; Huang, Chuyi
and Zhang, Caixia
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- in
- Nutrition and Cancer
- volume
- 73
- issue
- 9
- pages
- 1621 - 1630
- publisher
- Lawrence Erlbaum Associates
- external identifiers
-
- scopus:85089290407
- ISSN
- 1532-7914
- DOI
- 10.1080/01635581.2020.1804950
- language
- English
- LU publication?
- no
- id
- 43a29e79-3e2d-43cf-8bc4-e67831f179f2
- date added to LUP
- 2025-01-22 13:44:08
- date last changed
- 2025-10-14 10:51:47
@article{43a29e79-3e2d-43cf-8bc4-e67831f179f2,
abstract = {{Zinc and selenium may protect against colorectal cancer (CRC) progression through their anti-oxidative effects. This study examined the independent and combined effect of dietary zinc and selenium intake, and polymorphisms of the oxidative stress-related genes (superoxide dismutase 1, superoxide dismutase 2, glutathione peroxidase, and catalase) on CRC risk in a Chinese case-control study. A total of 493 cases and 498 sex and age-matched controls were randomly selected from an ongoing case-control study. Dietary information was assessed through face-to-face interviews using a validated food frequency questionnaire. Multiplex PCR-ligase detection reaction was used for genotyping the target SNPs. Multivariable logistic regression was used to estimate the odds ratios (ORs) and 95% confidence interval (CI). Intake of selenium was found to be inversely associated with CRC risk, while zinc was not associated with CRC risk. The ORs (95% CI) for the highest vs. the lowest quartile were 0.42 (95% CI 0.28, 0.64, Ptrend < 0.001) for selenium and 0.96 (95% CI 0.63, 1.47, Ptrend = 0.505) for zinc. Combined effect was observed between zinc and SOD1 rs4998557 on CRC risk (Pinteraction < 0.05). This study identified a novel diet-gene interaction in the oxidative stress pathway on CRC risk in Chinese population.}},
author = {{Luo, Hong and Fang, Yujing and Zhang, Xin and Feng, Xiaoli and Zhang, Naiqi and Abulimiti, Alinuer and Huang, Chuyi and Zhang, Caixia}},
issn = {{1532-7914}},
language = {{eng}},
number = {{9}},
pages = {{1621--1630}},
publisher = {{Lawrence Erlbaum Associates}},
series = {{Nutrition and Cancer}},
title = {{Association between Dietary Zinc and Selenium Intake, Oxidative Stress-Related Gene Polymorphism, and Colorectal Cancer Risk in Chinese Population - A Case-Control Study}},
url = {{http://dx.doi.org/10.1080/01635581.2020.1804950}},
doi = {{10.1080/01635581.2020.1804950}},
volume = {{73}},
year = {{2021}},
}