Absence of H-2 genetic influence on streptozotocin-induced diabetes in mice
Kromann, H. ; Christy, M. ; Egeberg, J. ; Lernmark, Å LU
and Nerup, J.
LU
(1982)
In Diabetologia
23(2).
p.114-118
- Abstract
Five daily injections of streptozotocin (40 mg/kg) produced a delayed but progressively increasing level of hyperglycaemia in long term studies with male Naval Medical Research Institute mice and C3D2F1 (DBA 2 J male × C3H/ Tif female) F1 hybrid mice. The development of hyperglycaemia was paralleled by decreased amounts of pancreatic immunoreactive insulin as well as degranulation and necrosis of pancreatic B cells. Insulitis was found from days 9-25 after the first injection of streptozotocin. Compared with the F1 hybrid strain the parental inbred strains DBA 2 J and C3H/Tif demonstrated a certain resistance to streptozotocin. Development of hyperglycaemia did not differ in four congenic resistant lines of mice on the C57 BL/10 genetic... (More)
Five daily injections of streptozotocin (40 mg/kg) produced a delayed but progressively increasing level of hyperglycaemia in long term studies with male Naval Medical Research Institute mice and C3D2F1 (DBA 2 J male × C3H/ Tif female) F1 hybrid mice. The development of hyperglycaemia was paralleled by decreased amounts of pancreatic immunoreactive insulin as well as degranulation and necrosis of pancreatic B cells. Insulitis was found from days 9-25 after the first injection of streptozotocin. Compared with the F1 hybrid strain the parental inbred strains DBA 2 J and C3H/Tif demonstrated a certain resistance to streptozotocin. Development of hyperglycaemia did not differ in four congenic resistant lines of mice on the C57 BL/10 genetic background, indicating that major histocompatibility complex genes are not likely to determine susceptibility to streptozotocin-induced islet B cell damage.
(Less)
- author
- Kromann, H.
; Christy, M.
; Egeberg, J.
; Lernmark, Å
LU
and Nerup, J.
LU
- publishing date
- 1982-08-01
- type
- Contribution to journal
- publication status
- published
- keywords
- experimental diabetes, H-2 system, insulitis, Mouse, sex hormone, streptozotocin
- in
- Diabetologia
- volume
- 23
- issue
- 2
- pages
- 5 pages
- publisher
- Springer
- external identifiers
-
- pmid:6215276
- scopus:0019993194
- ISSN
- 0012-186X
- DOI
- 10.1007/BF01271171
- language
- English
- LU publication?
- no
- id
- 43b469f8-f928-4945-99dd-942229cc2e6d
- date added to LUP
- 2019-09-16 15:31:53
- date last changed
- 2025-10-14 11:37:31
@article{43b469f8-f928-4945-99dd-942229cc2e6d,
abstract = {{<p>Five daily injections of streptozotocin (40 mg/kg) produced a delayed but progressively increasing level of hyperglycaemia in long term studies with male Naval Medical Research Institute mice and C3D2F1 (DBA 2 J male × C3H/ Tif female) F1 hybrid mice. The development of hyperglycaemia was paralleled by decreased amounts of pancreatic immunoreactive insulin as well as degranulation and necrosis of pancreatic B cells. Insulitis was found from days 9-25 after the first injection of streptozotocin. Compared with the F1 hybrid strain the parental inbred strains DBA 2 J and C3H/Tif demonstrated a certain resistance to streptozotocin. Development of hyperglycaemia did not differ in four congenic resistant lines of mice on the C57 BL/10 genetic background, indicating that major histocompatibility complex genes are not likely to determine susceptibility to streptozotocin-induced islet B cell damage.</p>}},
author = {{Kromann, H. and Christy, M. and Egeberg, J. and Lernmark, Å and Nerup, J.}},
issn = {{0012-186X}},
keywords = {{experimental diabetes; H-2 system; insulitis; Mouse; sex hormone; streptozotocin}},
language = {{eng}},
month = {{08}},
number = {{2}},
pages = {{114--118}},
publisher = {{Springer}},
series = {{Diabetologia}},
title = {{Absence of H-2 genetic influence on streptozotocin-induced diabetes in mice}},
url = {{http://dx.doi.org/10.1007/BF01271171}},
doi = {{10.1007/BF01271171}},
volume = {{23}},
year = {{1982}},
}