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Extended vs. brief intermittent access to palatable food differently promote binge-like intake, rejection of less preferred food, and weight cycling in female rats

Kreisler, A. D. ; Garcia, M. G. LU orcid ; Spierling, S. R. ; Hui, B. E. and Zorrilla, E. P. (2017) In Physiology and Behavior 177. p.305-316
Abstract

Background Palatable food access promotes obesity leading some to diet. Here, we modeled the roles of duration, intermittency and choice of access in bingeing, escalation of daily intake, and underacceptance of alternatives. Method Female rats with (“Choice”) or without continuous chow access, received chow or continuous (Chocolate), intermittent (MWF) long (24 h, Int-Long), or intermittent short (30 min, Int-Short) access to a sucrose-rich, chocolate-flavored diet (CHOC). Results Int-Long rats showed cycling body weight; they overate CHOC, had increased feed efficiency on access days and underate chow and lost weight on non-access days, the latter correlating with their reduced brown fat. Int-Short rats had the greatest 30-min intake... (More)

Background Palatable food access promotes obesity leading some to diet. Here, we modeled the roles of duration, intermittency and choice of access in bingeing, escalation of daily intake, and underacceptance of alternatives. Method Female rats with (“Choice”) or without continuous chow access, received chow or continuous (Chocolate), intermittent (MWF) long (24 h, Int-Long), or intermittent short (30 min, Int-Short) access to a sucrose-rich, chocolate-flavored diet (CHOC). Results Int-Long rats showed cycling body weight; they overate CHOC, had increased feed efficiency on access days and underate chow and lost weight on non-access days, the latter correlating with their reduced brown fat. Int-Short rats had the greatest 30-min intake upon CHOC access, but did not underaccept chow or weight cycle. Individual vulnerability for intermittent access-induced feeding adaptations was seen. Continuous access rats gained fat disproportionate, but in direct relation, to their normalized energy intake and persistently underaccepted chow despite abstinence and return to normal weight. Abstinence reduced the binge-like CHOC intake of Int-Short rats and increased that of continuous access rats, but not to levels associated with intermittent access history. Choice increased daily CHOC intake under Continuous access and binge-like intake under Int-Short access. Conclusions Intermittency and duration of past access to palatable food have dissociable, individually-vulnerable influences on its intake and that of alternatives. With extended access, daily intake reflects the palatability of available food, rather than metabolic need. Ongoing restrictedness of access or a history of intermittency each drive binge-like intake. Aspects of palatable food availability, similar and different to drug availability, promote disordered eating.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adipose tissue or obesity, Binge eating disorder model, Food addiction or reward, Intermittent availability, Palatable food intake, Yo-yo diet cycling
in
Physiology and Behavior
volume
177
pages
305 - 316
publisher
Elsevier
external identifiers
  • pmid:28366814
  • scopus:85019563212
ISSN
0031-9384
DOI
10.1016/j.physbeh.2017.03.039
language
English
LU publication?
no
id
43c4f1d4-fc7a-4c88-85da-15e8d551fd54
date added to LUP
2019-09-06 12:30:46
date last changed
2024-06-26 02:05:17
@article{43c4f1d4-fc7a-4c88-85da-15e8d551fd54,
  abstract     = {{<p>Background Palatable food access promotes obesity leading some to diet. Here, we modeled the roles of duration, intermittency and choice of access in bingeing, escalation of daily intake, and underacceptance of alternatives. Method Female rats with (“Choice”) or without continuous chow access, received chow or continuous (Chocolate), intermittent (MWF) long (24 h, Int-Long), or intermittent short (30 min, Int-Short) access to a sucrose-rich, chocolate-flavored diet (CHOC). Results Int-Long rats showed cycling body weight; they overate CHOC, had increased feed efficiency on access days and underate chow and lost weight on non-access days, the latter correlating with their reduced brown fat. Int-Short rats had the greatest 30-min intake upon CHOC access, but did not underaccept chow or weight cycle. Individual vulnerability for intermittent access-induced feeding adaptations was seen. Continuous access rats gained fat disproportionate, but in direct relation, to their normalized energy intake and persistently underaccepted chow despite abstinence and return to normal weight. Abstinence reduced the binge-like CHOC intake of Int-Short rats and increased that of continuous access rats, but not to levels associated with intermittent access history. Choice increased daily CHOC intake under Continuous access and binge-like intake under Int-Short access. Conclusions Intermittency and duration of past access to palatable food have dissociable, individually-vulnerable influences on its intake and that of alternatives. With extended access, daily intake reflects the palatability of available food, rather than metabolic need. Ongoing restrictedness of access or a history of intermittency each drive binge-like intake. Aspects of palatable food availability, similar and different to drug availability, promote disordered eating.</p>}},
  author       = {{Kreisler, A. D. and Garcia, M. G. and Spierling, S. R. and Hui, B. E. and Zorrilla, E. P.}},
  issn         = {{0031-9384}},
  keywords     = {{Adipose tissue or obesity; Binge eating disorder model; Food addiction or reward; Intermittent availability; Palatable food intake; Yo-yo diet cycling}},
  language     = {{eng}},
  month        = {{08}},
  pages        = {{305--316}},
  publisher    = {{Elsevier}},
  series       = {{Physiology and Behavior}},
  title        = {{Extended vs. brief intermittent access to palatable food differently promote binge-like intake, rejection of less preferred food, and weight cycling in female rats}},
  url          = {{http://dx.doi.org/10.1016/j.physbeh.2017.03.039}},
  doi          = {{10.1016/j.physbeh.2017.03.039}},
  volume       = {{177}},
  year         = {{2017}},
}