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The many faces of diabetes: a disease with increasing heterogeneity

Tuomi, Tiinamaija; Santoro, Nicola; Caprio, Sonia; Cai, Mengyin; Weng, Jianping and Groop, Leif LU (2014) In The Lancet 383(9922). p.1084-1094
Abstract
Diabetes is a much more heterogeneous disease than the present subdivision into types 1 and 2 assumes; type 1 and type 2 diabetes probably represent extremes on a range of diabetic disorders. Both type 1 and type 2 diabetes seem to result from a collision between genes and environment. Although genetic predisposition establishes susceptibility, rapid changes in the environment (ie, lifestyle factors) are the most probable explanation for the increase in incidence of both forms of diabetes. Many patients have genetic predispositions to both forms of diabetes, resulting in hybrid forms of diabetes (eg, latent autoimmune diabetes in adults). Obesity is a strong modifi er of diabetes risk, and can account for not only a large proportion of the... (More)
Diabetes is a much more heterogeneous disease than the present subdivision into types 1 and 2 assumes; type 1 and type 2 diabetes probably represent extremes on a range of diabetic disorders. Both type 1 and type 2 diabetes seem to result from a collision between genes and environment. Although genetic predisposition establishes susceptibility, rapid changes in the environment (ie, lifestyle factors) are the most probable explanation for the increase in incidence of both forms of diabetes. Many patients have genetic predispositions to both forms of diabetes, resulting in hybrid forms of diabetes (eg, latent autoimmune diabetes in adults). Obesity is a strong modifi er of diabetes risk, and can account for not only a large proportion of the epidemic of type 2 diabetes in Asia but also the ever-increasing number of adolescents with type 2 diabetes. With improved characterisation of patients with diabetes, the range of diabetic subgroups will become even more diverse in the future. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Lancet
volume
383
issue
9922
pages
1084 - 1094
publisher
Elsevier Limited
external identifiers
  • wos:000333521200034
  • scopus:84896491806
ISSN
1474-547X
DOI
10.1016/S0140-6736(13)62219-9
language
English
LU publication?
yes
id
a4c9e9b1-975a-49c7-a234-30585a38ba9c (old id 4407582)
date added to LUP
2014-05-05 07:19:26
date last changed
2017-11-19 03:14:41
@article{a4c9e9b1-975a-49c7-a234-30585a38ba9c,
  abstract     = {Diabetes is a much more heterogeneous disease than the present subdivision into types 1 and 2 assumes; type 1 and type 2 diabetes probably represent extremes on a range of diabetic disorders. Both type 1 and type 2 diabetes seem to result from a collision between genes and environment. Although genetic predisposition establishes susceptibility, rapid changes in the environment (ie, lifestyle factors) are the most probable explanation for the increase in incidence of both forms of diabetes. Many patients have genetic predispositions to both forms of diabetes, resulting in hybrid forms of diabetes (eg, latent autoimmune diabetes in adults). Obesity is a strong modifi er of diabetes risk, and can account for not only a large proportion of the epidemic of type 2 diabetes in Asia but also the ever-increasing number of adolescents with type 2 diabetes. With improved characterisation of patients with diabetes, the range of diabetic subgroups will become even more diverse in the future.},
  author       = {Tuomi, Tiinamaija and Santoro, Nicola and Caprio, Sonia and Cai, Mengyin and Weng, Jianping and Groop, Leif},
  issn         = {1474-547X},
  language     = {eng},
  number       = {9922},
  pages        = {1084--1094},
  publisher    = {Elsevier Limited},
  series       = {The Lancet},
  title        = {The many faces of diabetes: a disease with increasing heterogeneity},
  url          = {http://dx.doi.org/10.1016/S0140-6736(13)62219-9},
  volume       = {383},
  year         = {2014},
}