Sodium-23 magnetic resonance imaging during and after transient cerebral ischemia: multinuclear stroke protocols for double-tuned Na-23/H-1 resonator systems
(2012) In Physics in Medicine and Biology 57(21). p.6929-6946- Abstract
- A double-tuned Na-23/H-1 resonator system was developed to record multinuclear MR image data during and after transient cerebral ischemia. H-1-diffusion-, H-1 perfusion, H-1 T2-, H-1 arterial blood flow-and Na-23 spin density-weighted images were then acquired at three time points in a rodent stroke model: (I) during 90 min artery occlusion, (II) directly after arterial reperfusion and (III) one day after arterial reperfusion. Normal Na-23 was detected in hypoperfused stroke tissue which exhibited a low H-1 apparent diffusion coefficient (ADC) and no changes in H-1 T-2 relaxation time during transient ischemia, while Na-23 increased and ADC values recovered to normal values directly after arterial reperfusion. For the first time, a similar... (More)
- A double-tuned Na-23/H-1 resonator system was developed to record multinuclear MR image data during and after transient cerebral ischemia. H-1-diffusion-, H-1 perfusion, H-1 T2-, H-1 arterial blood flow-and Na-23 spin density-weighted images were then acquired at three time points in a rodent stroke model: (I) during 90 min artery occlusion, (II) directly after arterial reperfusion and (III) one day after arterial reperfusion. Normal Na-23 was detected in hypoperfused stroke tissue which exhibited a low H-1 apparent diffusion coefficient (ADC) and no changes in H-1 T-2 relaxation time during transient ischemia, while Na-23 increased and ADC values recovered to normal values directly after arterial reperfusion. For the first time, a similar imaging protocol was set-up on a clinical 3T MRI site in conjunction with a commercial double-tuned H-1/Na-23 birdcage resonator avoiding a time-consuming exchange of resonators or MRI systems. Multinuclear Na-23/H-1 MRI data sets were obtained from one stroke patient during both the acute and non-acute stroke phases with an aquisition time of 22 min. The lesion exhibiting low ADC was found to be larger compared to the lesion with high Na-23 at 9 h after symptom onset. It is hoped that the presented pilot data demonstrate that fast multinuclear Na-23/H-1 MRI preclinical and clinical protocols can enable a better understanding of how temporal and regional MRI parameter changes link to pathophysiological variations in ischemic stroke tissue. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3256367
- author
- Wetterling, Friedrich ; Ansar, Saema LU and Handwerker, Eva
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physics in Medicine and Biology
- volume
- 57
- issue
- 21
- pages
- 6929 - 6946
- publisher
- IOP Publishing
- external identifiers
-
- wos:000310528700016
- scopus:84868024301
- pmid:23044614
- ISSN
- 1361-6560
- DOI
- 10.1088/0031-9155/57/21/6929
- language
- English
- LU publication?
- yes
- id
- 440b4026-d694-4ab5-b0e9-91797076168b (old id 3256367)
- date added to LUP
- 2016-04-01 10:58:08
- date last changed
- 2024-02-05 17:54:32
@article{440b4026-d694-4ab5-b0e9-91797076168b,
abstract = {{A double-tuned Na-23/H-1 resonator system was developed to record multinuclear MR image data during and after transient cerebral ischemia. H-1-diffusion-, H-1 perfusion, H-1 T2-, H-1 arterial blood flow-and Na-23 spin density-weighted images were then acquired at three time points in a rodent stroke model: (I) during 90 min artery occlusion, (II) directly after arterial reperfusion and (III) one day after arterial reperfusion. Normal Na-23 was detected in hypoperfused stroke tissue which exhibited a low H-1 apparent diffusion coefficient (ADC) and no changes in H-1 T-2 relaxation time during transient ischemia, while Na-23 increased and ADC values recovered to normal values directly after arterial reperfusion. For the first time, a similar imaging protocol was set-up on a clinical 3T MRI site in conjunction with a commercial double-tuned H-1/Na-23 birdcage resonator avoiding a time-consuming exchange of resonators or MRI systems. Multinuclear Na-23/H-1 MRI data sets were obtained from one stroke patient during both the acute and non-acute stroke phases with an aquisition time of 22 min. The lesion exhibiting low ADC was found to be larger compared to the lesion with high Na-23 at 9 h after symptom onset. It is hoped that the presented pilot data demonstrate that fast multinuclear Na-23/H-1 MRI preclinical and clinical protocols can enable a better understanding of how temporal and regional MRI parameter changes link to pathophysiological variations in ischemic stroke tissue.}},
author = {{Wetterling, Friedrich and Ansar, Saema and Handwerker, Eva}},
issn = {{1361-6560}},
language = {{eng}},
number = {{21}},
pages = {{6929--6946}},
publisher = {{IOP Publishing}},
series = {{Physics in Medicine and Biology}},
title = {{Sodium-23 magnetic resonance imaging during and after transient cerebral ischemia: multinuclear stroke protocols for double-tuned Na-23/H-1 resonator systems}},
url = {{http://dx.doi.org/10.1088/0031-9155/57/21/6929}},
doi = {{10.1088/0031-9155/57/21/6929}},
volume = {{57}},
year = {{2012}},
}