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Ultrasound Backscatter Measurements of Intact Human Proximal Femurs - Relationships of ultrasound parameters with tissue structure and mineral density.

Malo, M K H; Töyräs, J; Karjalainen, J P; Isaksson, Hanna LU ; Riekkinen, O and Jurvelin, J S (2014) In Bone 64(Online April 24, 2014). p.240-245
Abstract
Ultrasound reflection and backscatter parameters are related to mechanical and structural properties of bone in vitro. However, the potential of ultrasound reflection and backscatter measurements has not been tested with intact human proximal femurs ex vivo. We hypothesize that ultrasound backscatter can be measured from intact femurs and that the measured backscattered signal is associated with cadaver age, bone mineral density (BMD) and trabecular bone microstructure. In this study, human femoral bones of 16 male cadavers (47.0±16.1years, range: 21-77 years) were investigated using pulse-echo ultrasound measurements at the femoral neck in the antero-posterior direction and at the trochanter major in the antero-posterior and latero-medial... (More)
Ultrasound reflection and backscatter parameters are related to mechanical and structural properties of bone in vitro. However, the potential of ultrasound reflection and backscatter measurements has not been tested with intact human proximal femurs ex vivo. We hypothesize that ultrasound backscatter can be measured from intact femurs and that the measured backscattered signal is associated with cadaver age, bone mineral density (BMD) and trabecular bone microstructure. In this study, human femoral bones of 16 male cadavers (47.0±16.1years, range: 21-77 years) were investigated using pulse-echo ultrasound measurements at the femoral neck in the antero-posterior direction and at the trochanter major in the antero-posterior and latero-medial directions. Recently introduced ultrasound backscatter parameters, independent of cortical thickness, e.g., time slope of apparent integrated backscatter (TSAB) and mean of the backscatter difference technique (MBD) were obtained and compared with the structural properties of trabecular bone samples, extracted from the locations of ultrasound measurements. Moreover, more conventional backscatter parameters, e.g., apparent integrated backscatter (AIB) and frequency slope of apparent integrated backscatter (FSAB) were analysed. Bone mineral density of the intact femurs was evaluated using dual energy X-ray absorptiometry (DXA). AIB and MDB measured from the femoral neck correlated significantly (p<0.01) with the neck BMD (R(2)=0.44 and 0.45), cadaver age (R(2)=0.61 and 0.41) and several structural parameters, e.g., bone volume fraction (R(2)=0.33 and 0.39, p<0.05 and p<0.01), respectively. To conclude, ultrasound backscatter parameters, measured from intact proximal femurs, are significantly related (p<0.05) to trabecular bone structural properties and mineral density. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Bone
volume
64
issue
Online April 24, 2014
pages
240 - 245
publisher
Elsevier
external identifiers
  • pmid:24769331
  • wos:000337011500033
  • scopus:84899844726
ISSN
1873-2763
DOI
10.1016/j.bone.2014.04.014
language
English
LU publication?
yes
id
efd31b3b-4633-4c36-8027-01d803f59540 (old id 4429406)
date added to LUP
2014-05-06 10:41:03
date last changed
2017-11-05 03:21:38
@article{efd31b3b-4633-4c36-8027-01d803f59540,
  abstract     = {Ultrasound reflection and backscatter parameters are related to mechanical and structural properties of bone in vitro. However, the potential of ultrasound reflection and backscatter measurements has not been tested with intact human proximal femurs ex vivo. We hypothesize that ultrasound backscatter can be measured from intact femurs and that the measured backscattered signal is associated with cadaver age, bone mineral density (BMD) and trabecular bone microstructure. In this study, human femoral bones of 16 male cadavers (47.0±16.1years, range: 21-77 years) were investigated using pulse-echo ultrasound measurements at the femoral neck in the antero-posterior direction and at the trochanter major in the antero-posterior and latero-medial directions. Recently introduced ultrasound backscatter parameters, independent of cortical thickness, e.g., time slope of apparent integrated backscatter (TSAB) and mean of the backscatter difference technique (MBD) were obtained and compared with the structural properties of trabecular bone samples, extracted from the locations of ultrasound measurements. Moreover, more conventional backscatter parameters, e.g., apparent integrated backscatter (AIB) and frequency slope of apparent integrated backscatter (FSAB) were analysed. Bone mineral density of the intact femurs was evaluated using dual energy X-ray absorptiometry (DXA). AIB and MDB measured from the femoral neck correlated significantly (p&lt;0.01) with the neck BMD (R(2)=0.44 and 0.45), cadaver age (R(2)=0.61 and 0.41) and several structural parameters, e.g., bone volume fraction (R(2)=0.33 and 0.39, p&lt;0.05 and p&lt;0.01), respectively. To conclude, ultrasound backscatter parameters, measured from intact proximal femurs, are significantly related (p&lt;0.05) to trabecular bone structural properties and mineral density.},
  author       = {Malo, M K H and Töyräs, J and Karjalainen, J P and Isaksson, Hanna and Riekkinen, O and Jurvelin, J S},
  issn         = {1873-2763},
  language     = {eng},
  number       = {Online April 24, 2014},
  pages        = {240--245},
  publisher    = {Elsevier},
  series       = {Bone},
  title        = {Ultrasound Backscatter Measurements of Intact Human Proximal Femurs - Relationships of ultrasound parameters with tissue structure and mineral density.},
  url          = {http://dx.doi.org/10.1016/j.bone.2014.04.014},
  volume       = {64},
  year         = {2014},
}