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Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays.

Pauly, Frida LU ; Smedby, Karin E; Jerkeman, Mats LU ; Hjalgrim, Henrik; Ohlsson, Mattias LU ; Rosenquist, Richard; Borrebaeck, Carl A K and Wingren, Christer LU (2014) In Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis 38(6). p.682-690
Abstract
B-cell lymphoma (BCL) heterogeneity represents a key issue, often making the classification and clinical management of these patients challenging. In this pilot study, we outlined the first resolved view of BCL disease heterogeneity on the protein level by deciphering disease-associated plasma biomarkers, specific for chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma, using recombinant antibody microarrays targeting mainly immunoregulatory proteins. The results showed the BCLs to be heterogeneous, and revealed potential novel subgroups of each BCL. In the case of diffuse large B-cell lymphoma, we also indicated a link between the novel subgroups and survival.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis
volume
38
issue
6
pages
682 - 690
publisher
Elsevier
external identifiers
  • pmid:24754901
  • wos:000335919000006
  • scopus:84900431021
ISSN
1873-5835
DOI
10.1016/j.leukres.2014.03.010
project
CREATE Health
language
English
LU publication?
yes
id
12bf485a-1129-4b44-906d-73506d6c0008 (old id 4429653)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24754901?dopt=Abstract
date added to LUP
2014-05-04 15:49:37
date last changed
2017-10-22 03:26:05
@article{12bf485a-1129-4b44-906d-73506d6c0008,
  abstract     = {B-cell lymphoma (BCL) heterogeneity represents a key issue, often making the classification and clinical management of these patients challenging. In this pilot study, we outlined the first resolved view of BCL disease heterogeneity on the protein level by deciphering disease-associated plasma biomarkers, specific for chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and mantle cell lymphoma, using recombinant antibody microarrays targeting mainly immunoregulatory proteins. The results showed the BCLs to be heterogeneous, and revealed potential novel subgroups of each BCL. In the case of diffuse large B-cell lymphoma, we also indicated a link between the novel subgroups and survival.},
  author       = {Pauly, Frida and Smedby, Karin E and Jerkeman, Mats and Hjalgrim, Henrik and Ohlsson, Mattias and Rosenquist, Richard and Borrebaeck, Carl A K and Wingren, Christer},
  issn         = {1873-5835},
  language     = {eng},
  number       = {6},
  pages        = {682--690},
  publisher    = {Elsevier},
  series       = {Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis},
  title        = {Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays.},
  url          = {http://dx.doi.org/10.1016/j.leukres.2014.03.010},
  volume       = {38},
  year         = {2014},
}