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The Humoral Pattern Recognition Molecule PTX3 Is a Key Component of Innate Immunity against Urinary Tract Infection.

Jaillon, Sébastien; Moalli, Federica; Ragnarsdottir, Bryndis LU ; Bonavita, Eduardo; Puthia, Manoj LU ; Riva, Federica; Barbati, Elisa; Nebuloni, Manuela; Cvetko Krajinovic, Lidija and Markotic, Alemka, et al. (2014) In Immunity 40(4). p.621-632
Abstract
Immunity in the urinary tract has distinct and poorly understood pathophysiological characteristics and urinary tract infections (UTIs) are important causes of morbidity and mortality. We investigated the role of the soluble pattern recognition molecule pentraxin 3 (PTX3), a key component of the humoral arm of innate immunity, in UTIs. PTX3-deficient mice showed defective control of UTIs and exacerbated inflammation. Expression of PTX3 was induced in uroepithelial cells by uropathogenic Escherichia coli (UPEC) in a Toll-like receptor 4 (TLR4)- and MyD88-dependent manner. PTX3 enhanced UPEC phagocytosis and phagosome maturation by neutrophils. PTX3 was detected in urine of UTI patients and amounts correlated with disease severity. In... (More)
Immunity in the urinary tract has distinct and poorly understood pathophysiological characteristics and urinary tract infections (UTIs) are important causes of morbidity and mortality. We investigated the role of the soluble pattern recognition molecule pentraxin 3 (PTX3), a key component of the humoral arm of innate immunity, in UTIs. PTX3-deficient mice showed defective control of UTIs and exacerbated inflammation. Expression of PTX3 was induced in uroepithelial cells by uropathogenic Escherichia coli (UPEC) in a Toll-like receptor 4 (TLR4)- and MyD88-dependent manner. PTX3 enhanced UPEC phagocytosis and phagosome maturation by neutrophils. PTX3 was detected in urine of UTI patients and amounts correlated with disease severity. In cohorts of UTI-prone patients, PTX3 gene polymorphisms correlated with susceptibility to acute pyelonephritis and cystitis. These results suggest that PTX3 is an essential component of innate resistance against UTIs. Thus, the cellular and humoral arms of innate immunity exert complementary functions in mediating resistance against UTIs. (Less)
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Contribution to journal
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published
subject
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Immunity
volume
40
issue
4
pages
621 - 632
publisher
Cell Press
external identifiers
  • pmid:24745336
  • wos:000334849400018
  • scopus:84898685230
ISSN
1074-7613
DOI
10.1016/j.immuni.2014.02.015
language
English
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yes
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e51ba7bd-5b3d-4f79-a8a5-311caf29d056 (old id 4429864)
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http://www.ncbi.nlm.nih.gov/pubmed/24745336?dopt=Abstract
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2014-05-05 13:46:56
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2017-10-22 03:26:00
@article{e51ba7bd-5b3d-4f79-a8a5-311caf29d056,
  abstract     = {Immunity in the urinary tract has distinct and poorly understood pathophysiological characteristics and urinary tract infections (UTIs) are important causes of morbidity and mortality. We investigated the role of the soluble pattern recognition molecule pentraxin 3 (PTX3), a key component of the humoral arm of innate immunity, in UTIs. PTX3-deficient mice showed defective control of UTIs and exacerbated inflammation. Expression of PTX3 was induced in uroepithelial cells by uropathogenic Escherichia coli (UPEC) in a Toll-like receptor 4 (TLR4)- and MyD88-dependent manner. PTX3 enhanced UPEC phagocytosis and phagosome maturation by neutrophils. PTX3 was detected in urine of UTI patients and amounts correlated with disease severity. In cohorts of UTI-prone patients, PTX3 gene polymorphisms correlated with susceptibility to acute pyelonephritis and cystitis. These results suggest that PTX3 is an essential component of innate resistance against UTIs. Thus, the cellular and humoral arms of innate immunity exert complementary functions in mediating resistance against UTIs.},
  author       = {Jaillon, Sébastien and Moalli, Federica and Ragnarsdottir, Bryndis and Bonavita, Eduardo and Puthia, Manoj and Riva, Federica and Barbati, Elisa and Nebuloni, Manuela and Cvetko Krajinovic, Lidija and Markotic, Alemka and Valentino, Sonia and Doni, Andrea and Tartari, Silvia and Graziani, Giorgio and Montanelli, Alessandro and Delneste, Yves and Svanborg, Catharina and Garlanda, Cecilia and Mantovani, Alberto},
  issn         = {1074-7613},
  language     = {eng},
  number       = {4},
  pages        = {621--632},
  publisher    = {Cell Press},
  series       = {Immunity},
  title        = {The Humoral Pattern Recognition Molecule PTX3 Is a Key Component of Innate Immunity against Urinary Tract Infection.},
  url          = {http://dx.doi.org/10.1016/j.immuni.2014.02.015},
  volume       = {40},
  year         = {2014},
}