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Familial colorectal cancer type X: genetic profiles and phenotypic features.

Dominguez, Mev LU ; Therkildsen, Christina LU ; Da Silva, Sabrina and Nilbert, Mef LU (2015) In Modern Pathology 28(1). p.30-36
Abstract
Heredity is a major cause of colorectal cancer, but although several rare high-risk syndromes have been linked to disease-predisposing mutations, the genetic mechanisms are undetermined in the majority of families suspected of hereditary cancer. We review the clinical presentation, histopathologic features, and the genetic and epigenetic profiles of the familial colorectal cancer type X (FCCTX) syndrome with the aim to delineate tumor characteristics that may contribute to refined diagnostics and optimized tumor prevention.Modern Pathology advance online publication, 18 April 2014; doi:10.1038/modpathol.2014.49.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Modern Pathology
volume
28
issue
1
pages
30 - 36
publisher
Nature Publishing Group
external identifiers
  • pmid:24743215
  • wos:000347384200004
  • scopus:84920703226
ISSN
1530-0285
DOI
10.1038/modpathol.2014.49
language
English
LU publication?
yes
id
7e31bf4f-7ba1-4b45-b242-d3720f53de13 (old id 4429899)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24743215?dopt=Abstract
date added to LUP
2014-05-05 17:35:37
date last changed
2017-08-27 03:00:21
@article{7e31bf4f-7ba1-4b45-b242-d3720f53de13,
  abstract     = {Heredity is a major cause of colorectal cancer, but although several rare high-risk syndromes have been linked to disease-predisposing mutations, the genetic mechanisms are undetermined in the majority of families suspected of hereditary cancer. We review the clinical presentation, histopathologic features, and the genetic and epigenetic profiles of the familial colorectal cancer type X (FCCTX) syndrome with the aim to delineate tumor characteristics that may contribute to refined diagnostics and optimized tumor prevention.Modern Pathology advance online publication, 18 April 2014; doi:10.1038/modpathol.2014.49.},
  author       = {Dominguez, Mev and Therkildsen, Christina and Da Silva, Sabrina and Nilbert, Mef},
  issn         = {1530-0285},
  language     = {eng},
  number       = {1},
  pages        = {30--36},
  publisher    = {Nature Publishing Group},
  series       = {Modern Pathology},
  title        = {Familial colorectal cancer type X: genetic profiles and phenotypic features.},
  url          = {http://dx.doi.org/10.1038/modpathol.2014.49},
  volume       = {28},
  year         = {2015},
}