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Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.

Zhou, Kaixin; Donnelly, Louise; Yang, Jian; Li, Miaoxin; Deshmukh, Harshal; Van Zuydam, Natalie; Ahlqvist, Emma LU ; Spencer, Chris C; Groop, Leif LU and Morris, Andrew D, et al. (2014) In The Lancet Diabetes & Endocrinology 2(6). p.481-487
Abstract
Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method.
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type
Contribution to journal
publication status
published
subject
in
The Lancet Diabetes & Endocrinology
volume
2
issue
6
pages
481 - 487
publisher
Elsevier
external identifiers
  • pmid:24731673
  • wos:000336724300025
  • scopus:84901638712
ISSN
2213-8595
DOI
10.1016/S2213-8587(14)70050-6
language
English
LU publication?
yes
id
87c28e03-dd82-4160-83ce-8c582e5e4c7c (old id 4430029)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24731673?dopt=Abstract
date added to LUP
2014-05-05 19:47:28
date last changed
2017-10-22 03:16:39
@article{87c28e03-dd82-4160-83ce-8c582e5e4c7c,
  abstract     = {Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method.},
  author       = {Zhou, Kaixin and Donnelly, Louise and Yang, Jian and Li, Miaoxin and Deshmukh, Harshal and Van Zuydam, Natalie and Ahlqvist, Emma and Spencer, Chris C and Groop, Leif and Morris, Andrew D and Colhoun, Helen M and Sham, Pak C and McCarthy, Mark I and Palmer, Colin N A and Pearson, Ewan R},
  issn         = {2213-8595},
  language     = {eng},
  number       = {6},
  pages        = {481--487},
  publisher    = {Elsevier},
  series       = {The Lancet Diabetes & Endocrinology},
  title        = {Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.},
  url          = {http://dx.doi.org/10.1016/S2213-8587(14)70050-6},
  volume       = {2},
  year         = {2014},
}