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Use of a standardized diagnostic approach improves the prognostic information of histopathologic factors in pancreatic and periampullary adenocarcinoma.

Elebro, Jacob LU and Jirström, Karin LU (2014) In Diagnostic Pathology 9(1).
Abstract
Variability in reported histopathology parameters in operated periampullary adenocarcinomas may affect the prognostic weight of the parameters. Standardized axial sectioning produces a higher incidence of involved margins and also seems to produce a lower relative incidence of pancreatic compared with distal bile duct origin and a higher incidence of involved lymph nodes, compared with non-standardized procedure. The aims of this study were to 1) assess how a previously not described standardized pathology procedure, with longitudinal sectioning along the distal bile duct, affects reported tumour origin, margin status and involved lymph nodes, compared with non-standardized procedure, 2) assess if re-evaluation of microscopic slides... (More)
Variability in reported histopathology parameters in operated periampullary adenocarcinomas may affect the prognostic weight of the parameters. Standardized axial sectioning produces a higher incidence of involved margins and also seems to produce a lower relative incidence of pancreatic compared with distal bile duct origin and a higher incidence of involved lymph nodes, compared with non-standardized procedure. The aims of this study were to 1) assess how a previously not described standardized pathology procedure, with longitudinal sectioning along the distal bile duct, affects reported tumour origin, margin status and involved lymph nodes, compared with non-standardized procedure, 2) assess if re-evaluation of microscopic slides affects the prognostic value of margin status and 3) compare the results of this standardized procedure with reported results of other standardized and non-standardized procedures. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diagnostic Pathology
volume
9
issue
1
publisher
BioMed Central
external identifiers
  • pmid:24731283
  • wos:000335186900001
  • scopus:84899656267
ISSN
1746-1596
DOI
10.1186/1746-1596-9-80
language
English
LU publication?
yes
id
43d76bf4-6a45-474c-ac3c-ce595e6d07e5 (old id 4430076)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24731283?dopt=Abstract
date added to LUP
2014-05-05 19:55:48
date last changed
2017-11-05 04:11:15
@article{43d76bf4-6a45-474c-ac3c-ce595e6d07e5,
  abstract     = {Variability in reported histopathology parameters in operated periampullary adenocarcinomas may affect the prognostic weight of the parameters. Standardized axial sectioning produces a higher incidence of involved margins and also seems to produce a lower relative incidence of pancreatic compared with distal bile duct origin and a higher incidence of involved lymph nodes, compared with non-standardized procedure. The aims of this study were to 1) assess how a previously not described standardized pathology procedure, with longitudinal sectioning along the distal bile duct, affects reported tumour origin, margin status and involved lymph nodes, compared with non-standardized procedure, 2) assess if re-evaluation of microscopic slides affects the prognostic value of margin status and 3) compare the results of this standardized procedure with reported results of other standardized and non-standardized procedures.},
  articleno    = {80},
  author       = {Elebro, Jacob and Jirström, Karin},
  issn         = {1746-1596},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Diagnostic Pathology},
  title        = {Use of a standardized diagnostic approach improves the prognostic information of histopathologic factors in pancreatic and periampullary adenocarcinoma.},
  url          = {http://dx.doi.org/10.1186/1746-1596-9-80},
  volume       = {9},
  year         = {2014},
}