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Use of a standardized diagnostic approach improves the prognostic information of histopathologic factors in pancreatic and periampullary adenocarcinoma.

Elebro, Jacob LU and Jirström, Karin LU (2014) In Diagnostic Pathology 9(1).
Abstract
Variability in reported histopathology parameters in operated periampullary adenocarcinomas may affect the prognostic weight of the parameters. Standardized axial sectioning produces a higher incidence of involved margins and also seems to produce a lower relative incidence of pancreatic compared with distal bile duct origin and a higher incidence of involved lymph nodes, compared with non-standardized procedure. The aims of this study were to 1) assess how a previously not described standardized pathology procedure, with longitudinal sectioning along the distal bile duct, affects reported tumour origin, margin status and involved lymph nodes, compared with non-standardized procedure, 2) assess if re-evaluation of microscopic slides... (More)
Variability in reported histopathology parameters in operated periampullary adenocarcinomas may affect the prognostic weight of the parameters. Standardized axial sectioning produces a higher incidence of involved margins and also seems to produce a lower relative incidence of pancreatic compared with distal bile duct origin and a higher incidence of involved lymph nodes, compared with non-standardized procedure. The aims of this study were to 1) assess how a previously not described standardized pathology procedure, with longitudinal sectioning along the distal bile duct, affects reported tumour origin, margin status and involved lymph nodes, compared with non-standardized procedure, 2) assess if re-evaluation of microscopic slides affects the prognostic value of margin status and 3) compare the results of this standardized procedure with reported results of other standardized and non-standardized procedures. (Less)
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diagnostic Pathology
volume
9
issue
1
article number
80
publisher
BioMed Central (BMC)
external identifiers
  • pmid:24731283
  • wos:000335186900001
  • scopus:84899656267
  • pmid:24731283
ISSN
1746-1596
DOI
10.1186/1746-1596-9-80
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
id
43d76bf4-6a45-474c-ac3c-ce595e6d07e5 (old id 4430076)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24731283?dopt=Abstract
date added to LUP
2016-04-01 14:34:43
date last changed
2021-09-15 04:00:37
@article{43d76bf4-6a45-474c-ac3c-ce595e6d07e5,
  abstract     = {Variability in reported histopathology parameters in operated periampullary adenocarcinomas may affect the prognostic weight of the parameters. Standardized axial sectioning produces a higher incidence of involved margins and also seems to produce a lower relative incidence of pancreatic compared with distal bile duct origin and a higher incidence of involved lymph nodes, compared with non-standardized procedure. The aims of this study were to 1) assess how a previously not described standardized pathology procedure, with longitudinal sectioning along the distal bile duct, affects reported tumour origin, margin status and involved lymph nodes, compared with non-standardized procedure, 2) assess if re-evaluation of microscopic slides affects the prognostic value of margin status and 3) compare the results of this standardized procedure with reported results of other standardized and non-standardized procedures.},
  author       = {Elebro, Jacob and Jirström, Karin},
  issn         = {1746-1596},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central (BMC)},
  series       = {Diagnostic Pathology},
  title        = {Use of a standardized diagnostic approach improves the prognostic information of histopathologic factors in pancreatic and periampullary adenocarcinoma.},
  url          = {https://lup.lub.lu.se/search/files/4046354/4882743},
  doi          = {10.1186/1746-1596-9-80},
  volume       = {9},
  year         = {2014},
}