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Hemodynamic Aging as the Consequence of Structural Changes Associated with Early Vascular Aging (EVA).

Nilsson, Peter LU (2014) In Aging and Disease 5(2). p.109-113
Abstract
An increase in peripheral vascular resistance at rest is not routinely observed in healthy older persons, but often associated with increased stiffness of central elastic arteries, as hallmarks of aging effects on the vasculature, referred to as early vascular aging (EVA). In clinical practice, the increased arterial stiffness translates into increased brachial and central systolic blood pressure and corresponding pulse pressure in subjects above 50 years of age, as well as increased carotid-femoral pulse wave velocity (c-f PWV), a marker of arterial stiffness. A c-f PWV value ≥ 10 m/s is currently defined as a threshold for increased cardiovascular risk, based on consensus statement from 2012. Prevention and treatment strategies include a... (More)
An increase in peripheral vascular resistance at rest is not routinely observed in healthy older persons, but often associated with increased stiffness of central elastic arteries, as hallmarks of aging effects on the vasculature, referred to as early vascular aging (EVA). In clinical practice, the increased arterial stiffness translates into increased brachial and central systolic blood pressure and corresponding pulse pressure in subjects above 50 years of age, as well as increased carotid-femoral pulse wave velocity (c-f PWV), a marker of arterial stiffness. A c-f PWV value ≥ 10 m/s is currently defined as a threshold for increased cardiovascular risk, based on consensus statement from 2012. Prevention and treatment strategies include a healthy lifestyle and the control of risk factors via appropriate drug therapy to achieve vascular protection related to EVA. New drugs are under development for vascular protection, for example the selective Angiotensin II (AT2) receptor agonist called compound 21. One target group for early intervention could be members of risk families including subjects with early onset cardiovascular disease. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Aging and Disease
volume
5
issue
2
pages
109 - 113
publisher
INT SOC AGING & DISEASE
external identifiers
  • pmid:24729936
  • wos:000336905200004
  • scopus:84916884031
ISSN
2152-5250
DOI
10.14336/AD.2014.0500109
language
English
LU publication?
yes
id
9f63bfe2-afe4-4db5-b3fc-376e3412ec3f (old id 4430126)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24729936?dopt=Abstract
date added to LUP
2014-05-05 20:13:39
date last changed
2017-11-05 04:00:39
@article{9f63bfe2-afe4-4db5-b3fc-376e3412ec3f,
  abstract     = {An increase in peripheral vascular resistance at rest is not routinely observed in healthy older persons, but often associated with increased stiffness of central elastic arteries, as hallmarks of aging effects on the vasculature, referred to as early vascular aging (EVA). In clinical practice, the increased arterial stiffness translates into increased brachial and central systolic blood pressure and corresponding pulse pressure in subjects above 50 years of age, as well as increased carotid-femoral pulse wave velocity (c-f PWV), a marker of arterial stiffness. A c-f PWV value ≥ 10 m/s is currently defined as a threshold for increased cardiovascular risk, based on consensus statement from 2012. Prevention and treatment strategies include a healthy lifestyle and the control of risk factors via appropriate drug therapy to achieve vascular protection related to EVA. New drugs are under development for vascular protection, for example the selective Angiotensin II (AT2) receptor agonist called compound 21. One target group for early intervention could be members of risk families including subjects with early onset cardiovascular disease.},
  author       = {Nilsson, Peter},
  issn         = {2152-5250},
  language     = {eng},
  number       = {2},
  pages        = {109--113},
  publisher    = {INT SOC AGING & DISEASE},
  series       = {Aging and Disease},
  title        = {Hemodynamic Aging as the Consequence of Structural Changes Associated with Early Vascular Aging (EVA).},
  url          = {http://dx.doi.org/10.14336/AD.2014.0500109},
  volume       = {5},
  year         = {2014},
}