Advanced

Does duration on antiretroviral therapy determine health-related quality of life in people living with HIV? A cross-sectional study in a regional referral hospital in Kenya.

Mûnene, Edwin and Ekman, Björn LU (2014) In Global Health Action 7(Apr 7).
Abstract
Objective : To measure the extent to which health-related quality of life (HRQoL) in people living with HIV is associated with duration of antiretroviral therapy (ART) after controlling for sociodemographic, clinical, and other therapy-related factors. Design : Cross-sectional analysis. Methods : A gender-stratified random sample of 421 participants aged 18-64 years was selected from the patients on ART at a health facility in Kenya. Three hundred and ninety two patients participated in the study, representing a 93% response rate. Data on general physical and mental health functioning status were collected using the SF-36 health survey questionnaire. Hierarchical logistic regression analysis was used to predict the SF-36 summary scores.... (More)
Objective : To measure the extent to which health-related quality of life (HRQoL) in people living with HIV is associated with duration of antiretroviral therapy (ART) after controlling for sociodemographic, clinical, and other therapy-related factors. Design : Cross-sectional analysis. Methods : A gender-stratified random sample of 421 participants aged 18-64 years was selected from the patients on ART at a health facility in Kenya. Three hundred and ninety two patients participated in the study, representing a 93% response rate. Data on general physical and mental health functioning status were collected using the SF-36 health survey questionnaire. Hierarchical logistic regression analysis was used to predict the SF-36 summary scores. Results : In regression analyses, the duration of ART was negatively associated with HRQoL (odds ratio (OR): 0.6, 95% confidence interval (CI): 0.45-0.92) after controlling for sociodemographic, clinical, and other therapy-related factors. Patients with chronic diseases or clinical symptoms of acute illness had significantly worse HRQoL (OR: 0.5, 95% CI: 0.30-0.79 and OR: 0.3, 95% CI: 0.16-0.59, respectively). Therapy interruptions, adverse drug reactions, and World Health Organization stage at initiation of therapy were not associated with HRQoL. Conclusion : Patients on ART for a relatively longer duration reported poorer HRQoL at the study facility independent of the effect of other therapy-related, clinical, and sociodemographic factors. Program managers and clinicians in the Kenyan health system may need to refocus attention on this subgroup to avert 'loss to treatment' that may have negative repercussions on the substantial gains made against the HIV scourge. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Global Health Action
volume
7
issue
Apr 7
publisher
Co-action Publishing
external identifiers
  • pmid:24713353
  • scopus:84904389874
ISSN
1654-9880
language
English
LU publication?
yes
id
0696ef2f-5048-4d95-8b77-991b1229b901 (old id 4430625)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24713353?dopt=Abstract
date added to LUP
2014-05-06 19:13:45
date last changed
2017-08-20 04:07:16
@article{0696ef2f-5048-4d95-8b77-991b1229b901,
  abstract     = {Objective : To measure the extent to which health-related quality of life (HRQoL) in people living with HIV is associated with duration of antiretroviral therapy (ART) after controlling for sociodemographic, clinical, and other therapy-related factors. Design : Cross-sectional analysis. Methods : A gender-stratified random sample of 421 participants aged 18-64 years was selected from the patients on ART at a health facility in Kenya. Three hundred and ninety two patients participated in the study, representing a 93% response rate. Data on general physical and mental health functioning status were collected using the SF-36 health survey questionnaire. Hierarchical logistic regression analysis was used to predict the SF-36 summary scores. Results : In regression analyses, the duration of ART was negatively associated with HRQoL (odds ratio (OR): 0.6, 95% confidence interval (CI): 0.45-0.92) after controlling for sociodemographic, clinical, and other therapy-related factors. Patients with chronic diseases or clinical symptoms of acute illness had significantly worse HRQoL (OR: 0.5, 95% CI: 0.30-0.79 and OR: 0.3, 95% CI: 0.16-0.59, respectively). Therapy interruptions, adverse drug reactions, and World Health Organization stage at initiation of therapy were not associated with HRQoL. Conclusion : Patients on ART for a relatively longer duration reported poorer HRQoL at the study facility independent of the effect of other therapy-related, clinical, and sociodemographic factors. Program managers and clinicians in the Kenyan health system may need to refocus attention on this subgroup to avert 'loss to treatment' that may have negative repercussions on the substantial gains made against the HIV scourge.},
  articleno    = {23554},
  author       = {Mûnene, Edwin and Ekman, Björn},
  issn         = {1654-9880},
  language     = {eng},
  number       = {Apr 7},
  publisher    = {Co-action Publishing},
  series       = {Global Health Action},
  title        = {Does duration on antiretroviral therapy determine health-related quality of life in people living with HIV? A cross-sectional study in a regional referral hospital in Kenya.},
  volume       = {7},
  year         = {2014},
}