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The coagulation system and its function in early immune defense.

van der Poll, T and Herwald, Heiko LU (2014) In Thrombosis and Haemostasis 112(4). p.640-648
Abstract
Blood coagulation has a Janus-faced role in infectious diseases. When systemically activated, it can cause serious complications associated with high morbidity and mortality. However, coagulation is also part of the innate immune system and its local activation has been found to play an important role in the early host response to infection. Though the latter aspect has been less investigated, phylogenetic studies have shown that many factors involved in coagulation have ancestral origins which are often combined with anti-microbial features. This review gives a general overview about the most recent advances in this area of research also referred to as immunothrombosis.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Thrombosis and Haemostasis
volume
112
issue
4
pages
640 - 648
publisher
F K Schattauer Verlag Gmbh
external identifiers
  • pmid:24696161
  • wos:000342655100005
  • scopus:84908555454
ISSN
0340-6245
DOI
10.1160/TH14-01-0053
language
English
LU publication?
yes
id
e57e2b83-0534-41d5-ae55-fd00b327aed8 (old id 4431156)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24696161?dopt=Abstract
date added to LUP
2014-05-06 21:31:31
date last changed
2017-11-19 03:58:00
@article{e57e2b83-0534-41d5-ae55-fd00b327aed8,
  abstract     = {Blood coagulation has a Janus-faced role in infectious diseases. When systemically activated, it can cause serious complications associated with high morbidity and mortality. However, coagulation is also part of the innate immune system and its local activation has been found to play an important role in the early host response to infection. Though the latter aspect has been less investigated, phylogenetic studies have shown that many factors involved in coagulation have ancestral origins which are often combined with anti-microbial features. This review gives a general overview about the most recent advances in this area of research also referred to as immunothrombosis.},
  author       = {van der Poll, T and Herwald, Heiko},
  issn         = {0340-6245},
  language     = {eng},
  number       = {4},
  pages        = {640--648},
  publisher    = {F K Schattauer Verlag Gmbh},
  series       = {Thrombosis and Haemostasis},
  title        = {The coagulation system and its function in early immune defense.},
  url          = {http://dx.doi.org/10.1160/TH14-01-0053},
  volume       = {112},
  year         = {2014},
}