The coagulation system and its function in early immune defense.
van der Poll, T and Herwald, Heiko LU
(2014)
In Thrombosis and Haemostasis
112(4).
p.640-648
- Abstract
- Blood coagulation has a Janus-faced role in infectious diseases. When systemically activated, it can cause serious complications associated with high morbidity and mortality. However, coagulation is also part of the innate immune system and its local activation has been found to play an important role in the early host response to infection. Though the latter aspect has been less investigated, phylogenetic studies have shown that many factors involved in coagulation have ancestral origins which are often combined with anti-microbial features. This review gives a general overview about the most recent advances in this area of research also referred to as immunothrombosis.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4431156
- author
- van der Poll, T
and Herwald, Heiko
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Thrombosis and Haemostasis
- volume
- 112
- issue
- 4
- pages
- 640 - 648
- publisher
- Schattauer GmbH
- external identifiers
-
- pmid:24696161
- wos:000342655100005
- scopus:84908555454
- pmid:24696161
- ISSN
- 0340-6245
- DOI
- 10.1160/TH14-01-0053
- project
- Contact system project
- language
- English
- LU publication?
- yes
- id
- e57e2b83-0534-41d5-ae55-fd00b327aed8 (old id 4431156)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24696161?dopt=Abstract
- date added to LUP
- 2016-04-01 14:36:19
- date last changed
- 2022-04-22 04:13:21
@article{e57e2b83-0534-41d5-ae55-fd00b327aed8,
abstract = {{Blood coagulation has a Janus-faced role in infectious diseases. When systemically activated, it can cause serious complications associated with high morbidity and mortality. However, coagulation is also part of the innate immune system and its local activation has been found to play an important role in the early host response to infection. Though the latter aspect has been less investigated, phylogenetic studies have shown that many factors involved in coagulation have ancestral origins which are often combined with anti-microbial features. This review gives a general overview about the most recent advances in this area of research also referred to as immunothrombosis.}},
author = {{van der Poll, T and Herwald, Heiko}},
issn = {{0340-6245}},
language = {{eng}},
number = {{4}},
pages = {{640--648}},
publisher = {{Schattauer GmbH}},
series = {{Thrombosis and Haemostasis}},
title = {{The coagulation system and its function in early immune defense.}},
url = {{https://lup.lub.lu.se/search/files/4065670/4926880.pdf}},
doi = {{10.1160/TH14-01-0053}},
volume = {{112}},
year = {{2014}},
}