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Superantigen activates the gp130 receptor on adipocytes resulting in altered adipocyte metabolism.

Banke, Elin LU ; Rödström, Karin LU ; Ekelund, Mikael LU ; Dalla-Riva, Jonathan LU ; Lagerstedt, Jens LU ; Nilsson, Staffan; Degerman, Eva LU ; Lindkvist, Karin LU and Nilson, Bo LU (2014) In Metabolism, Clinical and Experimental 63(6). p.831-840
Abstract
The bacteria Staphylococcus aureus is part of the normal bacterial flora and produces a repertoire of enterotoxins which can cause food poisoning and toxic shock and might contribute to the pathogenesis of inflammatory diseases. These enterotoxins directly cross-link the T cell receptor with MHC class II, activating large amounts of T cells and are therefore called superantigens. It was recently discovered that the superantigen SEA binds to the cytokine receptor gp130. As obesity and type 2 diabetes are highly associated with inflammation of the adipose tissue and gp130 has been shown to play an important role in adipocytes, we wanted to investigate the effect of SEA on adipocyte signaling and function.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Metabolism, Clinical and Experimental
volume
63
issue
6
pages
831 - 840
publisher
Elsevier
external identifiers
  • pmid:24684823
  • wos:000336640100012
  • scopus:84901194079
ISSN
1532-8600
DOI
10.1016/j.metabol.2014.03.004
language
English
LU publication?
yes
id
6b71981c-bb51-45cb-b18e-6210734d9171 (old id 4431427)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24684823?dopt=Abstract
date added to LUP
2014-05-07 19:04:19
date last changed
2017-02-05 03:21:16
@article{6b71981c-bb51-45cb-b18e-6210734d9171,
  abstract     = {The bacteria Staphylococcus aureus is part of the normal bacterial flora and produces a repertoire of enterotoxins which can cause food poisoning and toxic shock and might contribute to the pathogenesis of inflammatory diseases. These enterotoxins directly cross-link the T cell receptor with MHC class II, activating large amounts of T cells and are therefore called superantigens. It was recently discovered that the superantigen SEA binds to the cytokine receptor gp130. As obesity and type 2 diabetes are highly associated with inflammation of the adipose tissue and gp130 has been shown to play an important role in adipocytes, we wanted to investigate the effect of SEA on adipocyte signaling and function.},
  author       = {Banke, Elin and Rödström, Karin and Ekelund, Mikael and Dalla-Riva, Jonathan and Lagerstedt, Jens and Nilsson, Staffan and Degerman, Eva and Lindkvist, Karin and Nilson, Bo},
  issn         = {1532-8600},
  language     = {eng},
  number       = {6},
  pages        = {831--840},
  publisher    = {Elsevier},
  series       = {Metabolism, Clinical and Experimental},
  title        = {Superantigen activates the gp130 receptor on adipocytes resulting in altered adipocyte metabolism.},
  url          = {http://dx.doi.org/10.1016/j.metabol.2014.03.004},
  volume       = {63},
  year         = {2014},
}