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Cells, pathways, and models in dyskinesia research

Cenci, M. Angela LU orcid and Kumar, Arvind (2024) In Current Opinion in Neurobiology 84.
Abstract

L-DOPA-induced dyskinesia (LID) is the most common form of hyperkinetic movement disorder resulting from altered information processing in the cortico-basal ganglia network. We here review recent advances clarifying the altered interplay between striatal output pathways in this movement disorder. We also review studies revealing structural and synaptic changes to the striatal microcircuitry and altered cortico-striatal activity dynamics in LID. We furthermore highlight the recent progress made in understanding the involvement of cerebellar and brain stem nuclei. These recent developments illustrate that dyskinesia research continues to provide key insights into cellular and circuit-level plasticity within the cortico-basal ganglia... (More)

L-DOPA-induced dyskinesia (LID) is the most common form of hyperkinetic movement disorder resulting from altered information processing in the cortico-basal ganglia network. We here review recent advances clarifying the altered interplay between striatal output pathways in this movement disorder. We also review studies revealing structural and synaptic changes to the striatal microcircuitry and altered cortico-striatal activity dynamics in LID. We furthermore highlight the recent progress made in understanding the involvement of cerebellar and brain stem nuclei. These recent developments illustrate that dyskinesia research continues to provide key insights into cellular and circuit-level plasticity within the cortico-basal ganglia network and its interconnected brain regions.

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author
and
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type
Contribution to journal
publication status
published
subject
in
Current Opinion in Neurobiology
volume
84
article number
102833
publisher
Elsevier
external identifiers
  • pmid:38184982
  • scopus:85182901300
ISSN
0959-4388
DOI
10.1016/j.conb.2023.102833
language
English
LU publication?
yes
id
44317eac-bcf6-4cf4-935b-d0d051e84ad0
date added to LUP
2024-02-22 10:29:04
date last changed
2024-04-23 16:12:42
@article{44317eac-bcf6-4cf4-935b-d0d051e84ad0,
  abstract     = {{<p>L-DOPA-induced dyskinesia (LID) is the most common form of hyperkinetic movement disorder resulting from altered information processing in the cortico-basal ganglia network. We here review recent advances clarifying the altered interplay between striatal output pathways in this movement disorder. We also review studies revealing structural and synaptic changes to the striatal microcircuitry and altered cortico-striatal activity dynamics in LID. We furthermore highlight the recent progress made in understanding the involvement of cerebellar and brain stem nuclei. These recent developments illustrate that dyskinesia research continues to provide key insights into cellular and circuit-level plasticity within the cortico-basal ganglia network and its interconnected brain regions.</p>}},
  author       = {{Cenci, M. Angela and Kumar, Arvind}},
  issn         = {{0959-4388}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Current Opinion in Neurobiology}},
  title        = {{Cells, pathways, and models in dyskinesia research}},
  url          = {{http://dx.doi.org/10.1016/j.conb.2023.102833}},
  doi          = {{10.1016/j.conb.2023.102833}},
  volume       = {{84}},
  year         = {{2024}},
}