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tenm, a Drosophila gene related to tenascin, is a new pair-rule gene

Baumgartner, Stefan LU orcid ; Martin, Doris ; Hagios, Carmen and Chiquet-Ehrismann, Ruth (1994) In EMBO Journal 13(16). p.3728-3740
Abstract

We describe the molecular characterization of the Drosophila gene tenm, a large transcription unit spanning > 110 kb of DNA. tenm encodes a large extracellular protein of 2515 amino acids related to the extracellular matrix molecule tenascin. The Tenm protein is found in seven stripes during the blastoderm stage, and each stripe overlaps with the even-skipped stripes. tenm mutants show a phenotype resembling that of odd-paired (opa), a member of the pair-rule class of segmentation genes. Thus, Tenm is the first example of a pair-rule gene product acting from outside the cell. While the Tenm protein is under the control of fushi tarazu and even-skipped, but not of opa,... (More)

We describe the molecular characterization of the Drosophila gene tenm, a large transcription unit spanning > 110 kb of DNA. tenm encodes a large extracellular protein of 2515 amino acids related to the extracellular matrix molecule tenascin. The Tenm protein is found in seven stripes during the blastoderm stage, and each stripe overlaps with the even-skipped stripes. tenm mutants show a phenotype resembling that of odd-paired (opa), a member of the pair-rule class of segmentation genes. Thus, Tenm is the first example of a pair-rule gene product acting from outside the cell. While the Tenm protein is under the control of fushi tarazu and even-skipped, but not of opa, at least two pair-rule genes, paired (prd) and sloppy paired (slp), and all segment-polarity genes analysed to date are under the control of tenm. Our data suggest that Tenm initiates a signal transduction cascade which acts, via or in concert with opa, on downstream targets such as prd, slp, gooseberry, engrailed and wingless, leading to an opa-like phenotype.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Drosophila, Pair-rule gene, Signal transduction, ten, Tenascin
in
EMBO Journal
volume
13
issue
16
pages
3728 - 3740
publisher
Oxford University Press
external identifiers
  • pmid:8070401
  • scopus:0028168901
ISSN
0261-4189
DOI
10.1002/j.1460-2075.1994.tb06682.x
language
English
LU publication?
no
id
44373b5c-6a29-4946-9d1e-9f3ec63df51d
date added to LUP
2019-05-21 14:08:06
date last changed
2024-01-01 05:55:33
@article{44373b5c-6a29-4946-9d1e-9f3ec63df51d,
  abstract     = {{<p>We describe the molecular characterization of the Drosophila gene ten<sup>m</sup>, a large transcription unit spanning &gt; 110 kb of DNA. ten<sup>m</sup> encodes a large extracellular protein of 2515 amino acids related to the extracellular matrix molecule tenascin. The Ten<sup>m</sup> protein is found in seven stripes during the blastoderm stage, and each stripe overlaps with the even-skipped stripes. ten<sup>m</sup> mutants show a phenotype resembling that of odd-paired (opa), a member of the pair-rule class of segmentation genes. Thus, Ten<sup>m</sup> is the first example of a pair-rule gene product acting from outside the cell. While the Ten<sup>m</sup> protein is under the control of fushi tarazu and even-skipped, but not of opa, at least two pair-rule genes, paired (prd) and sloppy paired (slp), and all segment-polarity genes analysed to date are under the control of ten<sup>m</sup>. Our data suggest that Ten<sup>m</sup> initiates a signal transduction cascade which acts, via or in concert with opa, on downstream targets such as prd, slp, gooseberry, engrailed and wingless, leading to an opa-like phenotype.</p>}},
  author       = {{Baumgartner, Stefan and Martin, Doris and Hagios, Carmen and Chiquet-Ehrismann, Ruth}},
  issn         = {{0261-4189}},
  keywords     = {{Drosophila; Pair-rule gene; Signal transduction; ten; Tenascin}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{16}},
  pages        = {{3728--3740}},
  publisher    = {{Oxford University Press}},
  series       = {{EMBO Journal}},
  title        = {{ten<sup>m</sup>, a Drosophila gene related to tenascin, is a new pair-rule gene}},
  url          = {{http://dx.doi.org/10.1002/j.1460-2075.1994.tb06682.x}},
  doi          = {{10.1002/j.1460-2075.1994.tb06682.x}},
  volume       = {{13}},
  year         = {{1994}},
}