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Yeast reveals unexpected roles and regulatory features of aquaporins and aquaglyceroporins

Ahmadpour, Doryaneh; Geijer, Cecilia; Tamas, Markus J.; Lindkvist, Karin LU and Hohmann, Stefan (2014) In Biochimica et Biophysica Acta. General Subjects 1840(5). p.1482-1491
Abstract
Background: The yeast Saccharomyces cerevisiae provides unique opportunities to study roles and regulation of aqua/glyceroporins using frontline tools of genetics and genomics as well as molecular cell and systems biology. Scope of review: S. cerevisiae has two similar orthodox aquaporins. Based on phenotypes mediated by gene deletion or overexpression as well as on their expression pattern, the yeast aquaporins play important roles in key aspects of yeast biology: establishment of freeze tolerance, during spore formation as well as determination of cell surface properties for substrate adhesion and colony formation. Exactly how the aquaporins perform those roles and the mechanisms that regulate their function under such conditions remain... (More)
Background: The yeast Saccharomyces cerevisiae provides unique opportunities to study roles and regulation of aqua/glyceroporins using frontline tools of genetics and genomics as well as molecular cell and systems biology. Scope of review: S. cerevisiae has two similar orthodox aquaporins. Based on phenotypes mediated by gene deletion or overexpression as well as on their expression pattern, the yeast aquaporins play important roles in key aspects of yeast biology: establishment of freeze tolerance, during spore formation as well as determination of cell surface properties for substrate adhesion and colony formation. Exactly how the aquaporins perform those roles and the mechanisms that regulate their function under such conditions remain to be elucidated. S. cerevisiae also has two different aquaglyceroporins. While the role of one of them, Yfl054c, remains to be determined, Fps1 plays critical roles in osmoregulation by controlling the accumulation of the osmolyte glycerol. Fpsl communicates with two osmo-sensing MAPK signalling pathways to perform its functions but the details of Fps1 regulation remain to be determined. Major conclusions: Several phenotypes associated with aqua/glyceroporin function in yeasts have been established. However, how water and glycerol transport contribute to the observed effects is not understood in detail. Also many of the basic principles of regulation of yeast aqua/glyceroporins remain to be elucidated. General significance: Studying the yeast aquaporins and aquaglyceroporins offers rich insight into the life style, evolution and adaptive responses of yeast and rewards us with discoveries of unexpected roles and regulatory mechanisms of members of this ancient protein family. This article is part of a Special Issue entitled Aquaporins. (c) 2013 Elsevier B.V. All rights reserved. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
keywords
Aquaporin, Osmoregulation, Freeze tolerance, Stress resistance, Signal, transduction, MAPK pathway
in
Biochimica et Biophysica Acta. General Subjects
volume
1840
issue
5
pages
1482 - 1491
publisher
Elsevier
external identifiers
  • wos:000334088700004
  • scopus:84897114271
ISSN
0304-4165
DOI
10.1016/j.bbagen.2013.09.027
language
English
LU publication?
yes
id
f094f8d9-eeb6-4617-a174-3316b8a76a18 (old id 4438844)
date added to LUP
2014-07-01 07:42:54
date last changed
2017-11-19 03:51:59
@article{f094f8d9-eeb6-4617-a174-3316b8a76a18,
  abstract     = {Background: The yeast Saccharomyces cerevisiae provides unique opportunities to study roles and regulation of aqua/glyceroporins using frontline tools of genetics and genomics as well as molecular cell and systems biology. Scope of review: S. cerevisiae has two similar orthodox aquaporins. Based on phenotypes mediated by gene deletion or overexpression as well as on their expression pattern, the yeast aquaporins play important roles in key aspects of yeast biology: establishment of freeze tolerance, during spore formation as well as determination of cell surface properties for substrate adhesion and colony formation. Exactly how the aquaporins perform those roles and the mechanisms that regulate their function under such conditions remain to be elucidated. S. cerevisiae also has two different aquaglyceroporins. While the role of one of them, Yfl054c, remains to be determined, Fps1 plays critical roles in osmoregulation by controlling the accumulation of the osmolyte glycerol. Fpsl communicates with two osmo-sensing MAPK signalling pathways to perform its functions but the details of Fps1 regulation remain to be determined. Major conclusions: Several phenotypes associated with aqua/glyceroporin function in yeasts have been established. However, how water and glycerol transport contribute to the observed effects is not understood in detail. Also many of the basic principles of regulation of yeast aqua/glyceroporins remain to be elucidated. General significance: Studying the yeast aquaporins and aquaglyceroporins offers rich insight into the life style, evolution and adaptive responses of yeast and rewards us with discoveries of unexpected roles and regulatory mechanisms of members of this ancient protein family. This article is part of a Special Issue entitled Aquaporins. (c) 2013 Elsevier B.V. All rights reserved.},
  author       = {Ahmadpour, Doryaneh and Geijer, Cecilia and Tamas, Markus J. and Lindkvist, Karin and Hohmann, Stefan},
  issn         = {0304-4165},
  keyword      = {Aquaporin,Osmoregulation,Freeze tolerance,Stress resistance,Signal,transduction,MAPK pathway},
  language     = {eng},
  number       = {5},
  pages        = {1482--1491},
  publisher    = {Elsevier},
  series       = {Biochimica et Biophysica Acta. General Subjects},
  title        = {Yeast reveals unexpected roles and regulatory features of aquaporins and aquaglyceroporins},
  url          = {http://dx.doi.org/10.1016/j.bbagen.2013.09.027},
  volume       = {1840},
  year         = {2014},
}