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The Role of Nitric Oxide Synthase in Post-Operative Hyperglycaemia

Qader, Saleem LU (2008) In Libyan Journal of Medicine 3(3). p.144-147
Abstract
Post-operative hyperglycaemia is important with regard to outcomes of surgical operations. It affects postoperative morbidity, length of hospital stay, and mortality. Poor peri-operative blood glucose control leads to a higher risk of post-operative complication. Insulin resistance as a cause of post-operative hyperglycaemia has been blamed for some time. Nitric Oxide (NO) is produced by nitric oxide synthase (NOS) isoenzymes. Inducible nitric oxide synthase (iNOS) is not a normal cellular constitute. It is expressed by cytokines and non-cytokines e. g. fasting, trauma, intravenous glucose, and lipid infusion, which are encountered in surgical operations. Review of current published data on postoperative hyperglycaemia was completed. Our... (More)
Post-operative hyperglycaemia is important with regard to outcomes of surgical operations. It affects postoperative morbidity, length of hospital stay, and mortality. Poor peri-operative blood glucose control leads to a higher risk of post-operative complication. Insulin resistance as a cause of post-operative hyperglycaemia has been blamed for some time. Nitric Oxide (NO) is produced by nitric oxide synthase (NOS) isoenzymes. Inducible nitric oxide synthase (iNOS) is not a normal cellular constitute. It is expressed by cytokines and non-cytokines e. g. fasting, trauma, intravenous glucose, and lipid infusion, which are encountered in surgical operations. Review of current published data on postoperative hyperglycaemia was completed. Our studies and others were explored for the possible role of NO in this scenario. Induction and expression of iNOS enzyme in pancreatic islet cells is included in the chaotic postoperative blood glucose control. The high concentrations of iNOS derived NO are toxic to pancreatic beta-cells and may inhibit insulin secretion postoperatively. Hence, current peri-operative management is questionable regarding post-operative hyperglycaemia and necessitates development of a new strategy. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
NO, glucotoxicity, lipotoxicity, post-operative hyperglycaemia, pancreatic islets
in
Libyan Journal of Medicine
volume
3
issue
3
pages
144 - 147
publisher
Univ Alfateh, Fac Med
external identifiers
  • wos:000207456200009
ISSN
1993-2820
language
English
LU publication?
yes
id
ac7cb0d2-e0e1-4079-a7e0-2ed9b747cc9c (old id 4442989)
date added to LUP
2014-05-19 17:24:47
date last changed
2016-09-30 05:40:32
@article{ac7cb0d2-e0e1-4079-a7e0-2ed9b747cc9c,
  abstract     = {Post-operative hyperglycaemia is important with regard to outcomes of surgical operations. It affects postoperative morbidity, length of hospital stay, and mortality. Poor peri-operative blood glucose control leads to a higher risk of post-operative complication. Insulin resistance as a cause of post-operative hyperglycaemia has been blamed for some time. Nitric Oxide (NO) is produced by nitric oxide synthase (NOS) isoenzymes. Inducible nitric oxide synthase (iNOS) is not a normal cellular constitute. It is expressed by cytokines and non-cytokines e. g. fasting, trauma, intravenous glucose, and lipid infusion, which are encountered in surgical operations. Review of current published data on postoperative hyperglycaemia was completed. Our studies and others were explored for the possible role of NO in this scenario. Induction and expression of iNOS enzyme in pancreatic islet cells is included in the chaotic postoperative blood glucose control. The high concentrations of iNOS derived NO are toxic to pancreatic beta-cells and may inhibit insulin secretion postoperatively. Hence, current peri-operative management is questionable regarding post-operative hyperglycaemia and necessitates development of a new strategy.},
  author       = {Qader, Saleem},
  issn         = {1993-2820},
  keyword      = {NO,glucotoxicity,lipotoxicity,post-operative hyperglycaemia,pancreatic islets},
  language     = {eng},
  number       = {3},
  pages        = {144--147},
  publisher    = {Univ Alfateh, Fac Med},
  series       = {Libyan Journal of Medicine},
  title        = {The Role of Nitric Oxide Synthase in Post-Operative Hyperglycaemia},
  volume       = {3},
  year         = {2008},
}