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Non-invasive diagnostic methods of intracranial arteries

Ramgren, Birgitta LU (2014) In Lund University, Faculty of Medicine Doctoral dissertation Series 2014: 64.
Abstract
Aims of this thesis were to compare the agreement of different magnetic resonance angiography(MRA) techniques and digital subtraction angiography (DSA) in follow-up of intracranial aneurysms treated with coils in order to select the best MRA method, to evaluate the impact

of increased iodine concentration in contrast medium and decreased tube voltage on arterial attenuation and image quality in computed tomography angiography (CTA) of intracranial arteries, and finally to evaluate the diagnostic accuracy of CTA in non-traumatic subarachnoid

haemorrhage (SAH) compared to DSA and to assess the arterial attenuation (HU) as an image quality factor in this aspect.

Follow-up DSA and time-of-flight (TOF) MRA at 1.5T and... (More)
Aims of this thesis were to compare the agreement of different magnetic resonance angiography(MRA) techniques and digital subtraction angiography (DSA) in follow-up of intracranial aneurysms treated with coils in order to select the best MRA method, to evaluate the impact

of increased iodine concentration in contrast medium and decreased tube voltage on arterial attenuation and image quality in computed tomography angiography (CTA) of intracranial arteries, and finally to evaluate the diagnostic accuracy of CTA in non-traumatic subarachnoid

haemorrhage (SAH) compared to DSA and to assess the arterial attenuation (HU) as an image quality factor in this aspect.

Follow-up DSA and time-of-flight (TOF) MRA at 1.5T and 3T as well as contrast-enhanced MRA at 3T were performed in 37 patients with 41 coiled intracranial aneurysms. TOF-MRA at 3T showed best agreement with DSA.

One of three different combinations of iodine concentrations in contrast medium and CT tube voltages was tested in each of 63 patients referred for CTA of intracranial arteries. Increased iodine concentration (400 mgI/ml) and decreased tube voltage (90 kVp) improved image quality in CTA of intracranial arteries and arterial attenuation at 340 HU in the ICA was found to represent a cut-off level for examinations of good quality.

In 326 patients with non-traumatic SAH, diagnostic accuracy and arterial attenuation (HU),reflecting image quality, were assessed for CTA. CTA can be performed with high sensitivity(95%) and specificity (97%) for detection of ruptured aneurysms in the acute setting of SAH

and arterial attenuation is correlated to the sensitivity. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Professor Ekholm, Sven, Department of Radiology, University of Gothenburg
organization
publishing date
type
Thesis
publication status
published
subject
keywords
intracranial aneurysms, endovascular treatment, follow-up, subarachnoid haemorrhage, digital subtraction angiography, magnetic resonance angiography, computed tomography angiography, technical aspects, contrast agents, image quality
categories
Higher Education
in
Lund University, Faculty of Medicine Doctoral dissertation Series
volume
2014: 64
pages
116 pages
publisher
Diagnostic Radiology, (Lund)
defense location
demonstration room 10, Department of Medical Imaging and Physiology, Main building, level 4, Skåne University Hospital, Lund
defense date
2014-06-13 13:00
ISSN
1652-8220
ISBN
978-91-87651-90-8
language
English
LU publication?
yes
id
cf354135-919c-44f1-8bfa-3011cbebb058 (old id 4446126)
date added to LUP
2014-05-27 09:38:10
date last changed
2017-01-03 13:07:34
@phdthesis{cf354135-919c-44f1-8bfa-3011cbebb058,
  abstract     = {Aims of this thesis were to compare the agreement of different magnetic resonance angiography(MRA) techniques and digital subtraction angiography (DSA) in follow-up of intracranial aneurysms treated with coils in order to select the best MRA method, to evaluate the impact<br/><br>
of increased iodine concentration in contrast medium and decreased tube voltage on arterial attenuation and image quality in computed tomography angiography (CTA) of intracranial arteries, and finally to evaluate the diagnostic accuracy of CTA in non-traumatic subarachnoid<br/><br>
haemorrhage (SAH) compared to DSA and to assess the arterial attenuation (HU) as an image quality factor in this aspect.<br/><br>
Follow-up DSA and time-of-flight (TOF) MRA at 1.5T and 3T as well as contrast-enhanced MRA at 3T were performed in 37 patients with 41 coiled intracranial aneurysms. TOF-MRA at 3T showed best agreement with DSA.<br/><br>
One of three different combinations of iodine concentrations in contrast medium and CT tube voltages was tested in each of 63 patients referred for CTA of intracranial arteries. Increased iodine concentration (400 mgI/ml) and decreased tube voltage (90 kVp) improved image quality in CTA of intracranial arteries and arterial attenuation at 340 HU in the ICA was found to represent a cut-off level for examinations of good quality.<br/><br>
In 326 patients with non-traumatic SAH, diagnostic accuracy and arterial attenuation (HU),reflecting image quality, were assessed for CTA. CTA can be performed with high sensitivity(95%) and specificity (97%) for detection of ruptured aneurysms in the acute setting of SAH<br/><br>
and arterial attenuation is correlated to the sensitivity.},
  author       = {Ramgren, Birgitta},
  isbn         = {978-91-87651-90-8},
  issn         = {1652-8220},
  keyword      = {intracranial aneurysms,endovascular treatment,follow-up,subarachnoid haemorrhage,digital subtraction angiography,magnetic resonance angiography,computed tomography angiography,technical aspects,contrast agents,image quality},
  language     = {eng},
  pages        = {116},
  publisher    = {Diagnostic Radiology, (Lund)},
  school       = {Lund University},
  series       = {Lund University, Faculty of Medicine Doctoral dissertation Series},
  title        = {Non-invasive diagnostic methods of intracranial arteries},
  volume       = {2014: 64},
  year         = {2014},
}