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Biological dermal templates with native collagen scaffolds provide guiding ridges for invading cells and may promote structured dermal wound healing

Dill, Veronika and Mörgelin, Matthias LU (2020) In International Wound Journal 17(3). p.618-630
Abstract

Dermal substitutes are of major importance in treating full thickness skin defects. They come in a variety of materials manufactured into various forms, such as films, hydrocolloids, hydrogels, sponges, membranes, and electrospun micro- and nanofibers. Bioactive dermal substitutes act in wound healing either by delivery of bioactive compounds or by being constructed from materials having endogenous activity. The healing success rate is highly determined by cellular and physiological processes at the host-biomaterial interface during crucial wound healing steps. Hence, it is important to design appropriate wound treatment strategies with the ability to work actively with tissues and cells to enhance healing. Therefore, in this study, we... (More)

Dermal substitutes are of major importance in treating full thickness skin defects. They come in a variety of materials manufactured into various forms, such as films, hydrocolloids, hydrogels, sponges, membranes, and electrospun micro- and nanofibers. Bioactive dermal substitutes act in wound healing either by delivery of bioactive compounds or by being constructed from materials having endogenous activity. The healing success rate is highly determined by cellular and physiological processes at the host-biomaterial interface during crucial wound healing steps. Hence, it is important to design appropriate wound treatment strategies with the ability to work actively with tissues and cells to enhance healing. Therefore, in this study, we investigated biological dermal templates and their potential to stimulate natural cell adherence, guidance, and morphology. The most pronounced effect was observed in biomaterials with the highest content of native collagen networks. Cell attachment and proliferation were significantly enhanced on native collagen scaffolds. Cell morphology was more asymmetrical on such scaffolds, resembling native in vivo structures. Importantly, considerably lower expression of myofibroblast phenotype was observed on native collagen scaffolds. Our data suggest that this treatment strategy might be beneficial for the wound environment, with the potential to promote improved tissue regeneration and reduce abnormal scar formation.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bioactive dermal template, cell adherence, cell proliferation, native collagen scaffold, structured healing
in
International Wound Journal
volume
17
issue
3
pages
13 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85079371751
  • pmid:32045112
ISSN
1742-4801
DOI
10.1111/iwj.13314
language
English
LU publication?
yes
id
4451dc6b-99b6-40c3-9520-8bf0cf353ea0
date added to LUP
2020-03-03 14:30:05
date last changed
2024-09-04 17:55:22
@article{4451dc6b-99b6-40c3-9520-8bf0cf353ea0,
  abstract     = {{<p>Dermal substitutes are of major importance in treating full thickness skin defects. They come in a variety of materials manufactured into various forms, such as films, hydrocolloids, hydrogels, sponges, membranes, and electrospun micro- and nanofibers. Bioactive dermal substitutes act in wound healing either by delivery of bioactive compounds or by being constructed from materials having endogenous activity. The healing success rate is highly determined by cellular and physiological processes at the host-biomaterial interface during crucial wound healing steps. Hence, it is important to design appropriate wound treatment strategies with the ability to work actively with tissues and cells to enhance healing. Therefore, in this study, we investigated biological dermal templates and their potential to stimulate natural cell adherence, guidance, and morphology. The most pronounced effect was observed in biomaterials with the highest content of native collagen networks. Cell attachment and proliferation were significantly enhanced on native collagen scaffolds. Cell morphology was more asymmetrical on such scaffolds, resembling native in vivo structures. Importantly, considerably lower expression of myofibroblast phenotype was observed on native collagen scaffolds. Our data suggest that this treatment strategy might be beneficial for the wound environment, with the potential to promote improved tissue regeneration and reduce abnormal scar formation.</p>}},
  author       = {{Dill, Veronika and Mörgelin, Matthias}},
  issn         = {{1742-4801}},
  keywords     = {{bioactive dermal template; cell adherence; cell proliferation; native collagen scaffold; structured healing}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{618--630}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{International Wound Journal}},
  title        = {{Biological dermal templates with native collagen scaffolds provide guiding ridges for invading cells and may promote structured dermal wound healing}},
  url          = {{http://dx.doi.org/10.1111/iwj.13314}},
  doi          = {{10.1111/iwj.13314}},
  volume       = {{17}},
  year         = {{2020}},
}