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Are urinary PAHs biomarkers of controlled exposure to diesel exhaust?

Lu, S; Sobus, J; Sallsten, G; Albin, Maria LU ; Pleil, J; Gudmundsson, Anders LU ; Madden, M; Strandberg, B; Wierzbicka, Aneta LU and Rappaport, S (2014) In Biomarkers 19(4). p.332-339
Abstract
Urinary polycyclic aromatic hydrocarbons (PAHs) were evaluated as possible biomarkers of exposure to diesel exhaust (DE) in two controlled-chamber studies. We report levels of 14 PAHs from 28 subjects in urine that were collected before, immediately after and the morning after exposure. Using linear mixed-effects models, we tested for effects of DE exposure and several covariates (time, age, gender and urinary creatinine) on urinary PAH levels. DE exposures did not significantly alter urinary PAH levels. We conclude that urinary PAHs are not promising biomarkers of short-term exposures to DE in the range of 106-276 mu g/m(3).
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
diesel exhaust, Biomarker, PAHs, polycyclic aromatic hydrocarbons, urine
in
Biomarkers
volume
19
issue
4
pages
332 - 339
publisher
Taylor & Francis
external identifiers
  • wos:000336730300011
  • scopus:84901298187
ISSN
1366-5804
DOI
10.3109/1354750X.2014.910553
language
English
LU publication?
yes
id
157ffa88-89cd-4016-9560-22982ce1006f (old id 4452268)
date added to LUP
2014-11-14 12:32:55
date last changed
2017-09-24 03:11:19
@article{157ffa88-89cd-4016-9560-22982ce1006f,
  abstract     = {Urinary polycyclic aromatic hydrocarbons (PAHs) were evaluated as possible biomarkers of exposure to diesel exhaust (DE) in two controlled-chamber studies. We report levels of 14 PAHs from 28 subjects in urine that were collected before, immediately after and the morning after exposure. Using linear mixed-effects models, we tested for effects of DE exposure and several covariates (time, age, gender and urinary creatinine) on urinary PAH levels. DE exposures did not significantly alter urinary PAH levels. We conclude that urinary PAHs are not promising biomarkers of short-term exposures to DE in the range of 106-276 mu g/m(3).},
  author       = {Lu, S and Sobus, J and Sallsten, G and Albin, Maria and Pleil, J and Gudmundsson, Anders and Madden, M and Strandberg, B and Wierzbicka, Aneta and Rappaport, S},
  issn         = {1366-5804},
  keyword      = {diesel exhaust,Biomarker,PAHs,polycyclic aromatic hydrocarbons,urine},
  language     = {eng},
  number       = {4},
  pages        = {332--339},
  publisher    = {Taylor & Francis},
  series       = {Biomarkers},
  title        = {Are urinary PAHs biomarkers of controlled exposure to diesel exhaust?},
  url          = {http://dx.doi.org/10.3109/1354750X.2014.910553},
  volume       = {19},
  year         = {2014},
}