Advanced

A small-scale anatomical dosimetry model of the liver.

Stenvall, Anna LU ; Larsson, Erik LU ; Strand, Sven-Erik LU and Jönsson, Bo-Anders LU (2014) In Physics in Medicine and Biology 59(13). p.3353-3371
Abstract
Radionuclide therapy is a growing and promising approach for treating and prolonging the lives of patients with cancer. For therapies where high activities are administered, the liver can become a dose-limiting organ; often with a complex, non-uniform activity distribution and resulting non-uniform absorbed-dose distribution. This paper therefore presents a small-scale dosimetry model for various source-target combinations within the human liver microarchitecture. Using Monte Carlo simulations, Medical Internal Radiation Dose formalism-compatible specific absorbed fractions were calculated for monoenergetic electrons; photons; alpha particles; and (125)I, (90)Y, (211)At, (99m)Tc, (111)In, (177)Lu, (131)I and (18)F. S values and the ratio... (More)
Radionuclide therapy is a growing and promising approach for treating and prolonging the lives of patients with cancer. For therapies where high activities are administered, the liver can become a dose-limiting organ; often with a complex, non-uniform activity distribution and resulting non-uniform absorbed-dose distribution. This paper therefore presents a small-scale dosimetry model for various source-target combinations within the human liver microarchitecture. Using Monte Carlo simulations, Medical Internal Radiation Dose formalism-compatible specific absorbed fractions were calculated for monoenergetic electrons; photons; alpha particles; and (125)I, (90)Y, (211)At, (99m)Tc, (111)In, (177)Lu, (131)I and (18)F. S values and the ratio of local absorbed dose to the whole-organ average absorbed dose was calculated, enabling a transformation of dosimetry calculations from macro- to microstructure level. For heterogeneous activity distributions, for example uptake in Kupffer cells of radionuclides emitting low-energy electrons ((125)I) or high-LET alpha particles ((211)At) the target absorbed dose for the part of the space of Disse, closest to the source, was more than eight- and five-fold the average absorbed dose to the liver, respectively. With the increasing interest in radionuclide therapy of the liver, the presented model is an applicable tool for small-scale liver dosimetry in order to study detailed dose-effect relationships in the liver. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physics in Medicine and Biology
volume
59
issue
13
pages
3353 - 3371
publisher
IOP Publishing
external identifiers
  • pmid:24874832
  • wos:000338424800010
  • scopus:84902492696
ISSN
1361-6560
DOI
10.1088/0031-9155/59/13/3353
language
English
LU publication?
yes
id
0ae51b6a-cec9-4404-9064-c606d1fd00c5 (old id 4452349)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24874832?dopt=Abstract
date added to LUP
2014-06-08 21:12:16
date last changed
2017-02-05 03:16:12
@article{0ae51b6a-cec9-4404-9064-c606d1fd00c5,
  abstract     = {Radionuclide therapy is a growing and promising approach for treating and prolonging the lives of patients with cancer. For therapies where high activities are administered, the liver can become a dose-limiting organ; often with a complex, non-uniform activity distribution and resulting non-uniform absorbed-dose distribution. This paper therefore presents a small-scale dosimetry model for various source-target combinations within the human liver microarchitecture. Using Monte Carlo simulations, Medical Internal Radiation Dose formalism-compatible specific absorbed fractions were calculated for monoenergetic electrons; photons; alpha particles; and (125)I, (90)Y, (211)At, (99m)Tc, (111)In, (177)Lu, (131)I and (18)F. S values and the ratio of local absorbed dose to the whole-organ average absorbed dose was calculated, enabling a transformation of dosimetry calculations from macro- to microstructure level. For heterogeneous activity distributions, for example uptake in Kupffer cells of radionuclides emitting low-energy electrons ((125)I) or high-LET alpha particles ((211)At) the target absorbed dose for the part of the space of Disse, closest to the source, was more than eight- and five-fold the average absorbed dose to the liver, respectively. With the increasing interest in radionuclide therapy of the liver, the presented model is an applicable tool for small-scale liver dosimetry in order to study detailed dose-effect relationships in the liver.},
  author       = {Stenvall, Anna and Larsson, Erik and Strand, Sven-Erik and Jönsson, Bo-Anders},
  issn         = {1361-6560},
  language     = {eng},
  number       = {13},
  pages        = {3353--3371},
  publisher    = {IOP Publishing},
  series       = {Physics in Medicine and Biology},
  title        = {A small-scale anatomical dosimetry model of the liver.},
  url          = {http://dx.doi.org/10.1088/0031-9155/59/13/3353},
  volume       = {59},
  year         = {2014},
}