A small-scale anatomical dosimetry model of the liver.
(2014) In Physics in Medicine and Biology 59(13). p.3353-3371- Abstract
- Radionuclide therapy is a growing and promising approach for treating and prolonging the lives of patients with cancer. For therapies where high activities are administered, the liver can become a dose-limiting organ; often with a complex, non-uniform activity distribution and resulting non-uniform absorbed-dose distribution. This paper therefore presents a small-scale dosimetry model for various source-target combinations within the human liver microarchitecture. Using Monte Carlo simulations, Medical Internal Radiation Dose formalism-compatible specific absorbed fractions were calculated for monoenergetic electrons; photons; alpha particles; and (125)I, (90)Y, (211)At, (99m)Tc, (111)In, (177)Lu, (131)I and (18)F. S values and the ratio... (More)
- Radionuclide therapy is a growing and promising approach for treating and prolonging the lives of patients with cancer. For therapies where high activities are administered, the liver can become a dose-limiting organ; often with a complex, non-uniform activity distribution and resulting non-uniform absorbed-dose distribution. This paper therefore presents a small-scale dosimetry model for various source-target combinations within the human liver microarchitecture. Using Monte Carlo simulations, Medical Internal Radiation Dose formalism-compatible specific absorbed fractions were calculated for monoenergetic electrons; photons; alpha particles; and (125)I, (90)Y, (211)At, (99m)Tc, (111)In, (177)Lu, (131)I and (18)F. S values and the ratio of local absorbed dose to the whole-organ average absorbed dose was calculated, enabling a transformation of dosimetry calculations from macro- to microstructure level. For heterogeneous activity distributions, for example uptake in Kupffer cells of radionuclides emitting low-energy electrons ((125)I) or high-LET alpha particles ((211)At) the target absorbed dose for the part of the space of Disse, closest to the source, was more than eight- and five-fold the average absorbed dose to the liver, respectively. With the increasing interest in radionuclide therapy of the liver, the presented model is an applicable tool for small-scale liver dosimetry in order to study detailed dose-effect relationships in the liver. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4452349
- author
- Stenvall, Anna LU ; Larsson, Erik LU ; Strand, Sven-Erik LU and Jönsson, Bo-Anders LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physics in Medicine and Biology
- volume
- 59
- issue
- 13
- pages
- 3353 - 3371
- publisher
- IOP Publishing
- external identifiers
-
- pmid:24874832
- wos:000338424800010
- scopus:84902492696
- pmid:24874832
- ISSN
- 1361-6560
- DOI
- 10.1088/0031-9155/59/13/3353
- language
- English
- LU publication?
- yes
- id
- 0ae51b6a-cec9-4404-9064-c606d1fd00c5 (old id 4452349)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24874832?dopt=Abstract
- date added to LUP
- 2016-04-01 10:40:50
- date last changed
- 2022-04-04 20:22:14
@article{0ae51b6a-cec9-4404-9064-c606d1fd00c5,
abstract = {{Radionuclide therapy is a growing and promising approach for treating and prolonging the lives of patients with cancer. For therapies where high activities are administered, the liver can become a dose-limiting organ; often with a complex, non-uniform activity distribution and resulting non-uniform absorbed-dose distribution. This paper therefore presents a small-scale dosimetry model for various source-target combinations within the human liver microarchitecture. Using Monte Carlo simulations, Medical Internal Radiation Dose formalism-compatible specific absorbed fractions were calculated for monoenergetic electrons; photons; alpha particles; and (125)I, (90)Y, (211)At, (99m)Tc, (111)In, (177)Lu, (131)I and (18)F. S values and the ratio of local absorbed dose to the whole-organ average absorbed dose was calculated, enabling a transformation of dosimetry calculations from macro- to microstructure level. For heterogeneous activity distributions, for example uptake in Kupffer cells of radionuclides emitting low-energy electrons ((125)I) or high-LET alpha particles ((211)At) the target absorbed dose for the part of the space of Disse, closest to the source, was more than eight- and five-fold the average absorbed dose to the liver, respectively. With the increasing interest in radionuclide therapy of the liver, the presented model is an applicable tool for small-scale liver dosimetry in order to study detailed dose-effect relationships in the liver.}},
author = {{Stenvall, Anna and Larsson, Erik and Strand, Sven-Erik and Jönsson, Bo-Anders}},
issn = {{1361-6560}},
language = {{eng}},
number = {{13}},
pages = {{3353--3371}},
publisher = {{IOP Publishing}},
series = {{Physics in Medicine and Biology}},
title = {{A small-scale anatomical dosimetry model of the liver.}},
url = {{http://dx.doi.org/10.1088/0031-9155/59/13/3353}},
doi = {{10.1088/0031-9155/59/13/3353}},
volume = {{59}},
year = {{2014}},
}