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Presymptomatic autoantibodies in Sjögren's syndrome: what significance do they hold for the clinic?

Henriksson, Gunnel LU (2014) In Expert Review of Clinical Immunology 10(7). p.815-817
Abstract
In a number of autoimmune diseases, for example, rheumatoid arthritis and systemic lupus erythematosus, it is known that autoantibodies are present before the clinical onset. Recently we have shown that autoantibodies can be found many years before symptom onset in primary Sjögren's syndrome. This implies that screening for autoantibodies may be used to identify individuals at risk of developing systemic autoimmune disease. Possibly, autoantibody screening may also contribute to detection of incipient malignancy. This concept stems from a novel finding, on scleroderma patients, suggesting that an anti-tumor immune response elicited by a mutated self-antigen will cross-react with the unmodified version of the self-antigen, and thus come to... (More)
In a number of autoimmune diseases, for example, rheumatoid arthritis and systemic lupus erythematosus, it is known that autoantibodies are present before the clinical onset. Recently we have shown that autoantibodies can be found many years before symptom onset in primary Sjögren's syndrome. This implies that screening for autoantibodies may be used to identify individuals at risk of developing systemic autoimmune disease. Possibly, autoantibody screening may also contribute to detection of incipient malignancy. This concept stems from a novel finding, on scleroderma patients, suggesting that an anti-tumor immune response elicited by a mutated self-antigen will cross-react with the unmodified version of the self-antigen, and thus come to trigger the formation of autoantibodies. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Expert Review of Clinical Immunology
volume
10
issue
7
pages
815 - 817
publisher
Expert Reviews
external identifiers
  • pmid:24867307
  • wos:000337923500001
  • scopus:84902688116
ISSN
1744-8409
DOI
10.1586/1744666X.2014.922877
language
English
LU publication?
yes
id
55c81f9e-d50f-477d-9bd8-f3db99019a6a (old id 4452422)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24867307?dopt=Abstract
date added to LUP
2014-06-08 20:53:05
date last changed
2017-01-01 03:33:29
@misc{55c81f9e-d50f-477d-9bd8-f3db99019a6a,
  abstract     = {In a number of autoimmune diseases, for example, rheumatoid arthritis and systemic lupus erythematosus, it is known that autoantibodies are present before the clinical onset. Recently we have shown that autoantibodies can be found many years before symptom onset in primary Sjögren's syndrome. This implies that screening for autoantibodies may be used to identify individuals at risk of developing systemic autoimmune disease. Possibly, autoantibody screening may also contribute to detection of incipient malignancy. This concept stems from a novel finding, on scleroderma patients, suggesting that an anti-tumor immune response elicited by a mutated self-antigen will cross-react with the unmodified version of the self-antigen, and thus come to trigger the formation of autoantibodies.},
  author       = {Henriksson, Gunnel},
  issn         = {1744-8409},
  language     = {eng},
  number       = {7},
  pages        = {815--817},
  publisher    = {Expert Reviews},
  series       = {Expert Review of Clinical Immunology},
  title        = {Presymptomatic autoantibodies in Sjögren's syndrome: what significance do they hold for the clinic?},
  url          = {http://dx.doi.org/10.1586/1744666X.2014.922877},
  volume       = {10},
  year         = {2014},
}